Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
Elliott JG and Lachance PA Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. 1980 J. Nutr. pmid:7381607
Yu SG et al. Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. 1995 J. Nutr. pmid:7472655
Bell FP et al. L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits. 1992 J. Nutr. pmid:1552371
Ukai M et al. Cholesterol synthesis in germfree and conventional rats. 1976 J. Nutr. pmid:939998
Mukherjee C et al. In vitro studies on the effect of different dietary fats and different proportions of dietary protein on the synthesis of lipids by rat arterial tissue. 1971 J. Nutr. pmid:5578922
Peffley DM and Gayen AK Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. 2003 J. Nutr. pmid:12514264
He L et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. 1997 J. Nutr. pmid:9164984
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Grossi-Paoletti E et al. Lipids in brain tumors. 1971 J. Neurosurg. pmid:4323146
Kumar B et al. Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. 2002 J. Neurosci. Res. pmid:12111853
Michikawa M and Yanagisawa K Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. 1998 J. Neurosci. Res. pmid:9778150
Braun PE et al. Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes. 1991 J. Neurosci. Res. pmid:1666129
Rattan R et al. Rho/ROCK pathway as a target of tumor therapy. 2006 J. Neurosci. Res. pmid:16385577
Zacco A et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. 2003 J. Neurosci. pmid:14657168
Tanaka T et al. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. 2000 J. Neurosci. pmid:10751437
Cordle A and Landreth G 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. 2005 J. Neurosci. pmid:15647473
Fortin DL et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. 2004 J. Neurosci. pmid:15282274
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
Langan TJ and Volpe JJ Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures. 1987 J. Neurochem. pmid:3648095
Jones JP et al. Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. 1975 J. Neurochem. pmid:1110355
Rostas JA et al. Selective labelling of two phases of axonal transport of cholesterol in the chick optic system. 1979 J. Neurochem. pmid:86598
Sliwowski JK et al. The in vivo biosynthesis of cholesterol from (3RS,2R) [2-14C,2-3H]mevalonic acid in the brains of rats on normal and protein deficient diets. The stereochemistry of tritium atoms at C-7 and C-15. 1977 J. Neurochem. pmid:874493
Langan TJ and Volpe JJ Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate. 1987 J. Neurochem. pmid:3033149
Menkes JH Lipid metabolism in brain tissue explants. 1971 J. Neurochem. pmid:5092865
Hughes M et al. Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. 2010 J. Neurochem. pmid:20477946
Chevallier F and Gautheron C A method for the study of cholesterol biosynthesis in the central nervous system. Incorporation of [2-14C]mevalonic lactone after intraperitoneal, intracisternal and intraventricular administration in the rat. 1969 J. Neurochem. pmid:5795585
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. 1972 J. Neurochem. pmid:5009889
Parsons RB et al. A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. 2007 J. Neurochem. pmid:17472704
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. 1971 J. Neurochem. pmid:5092868
Kim WY et al. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. 2009 J. Neurochem. pmid:19209406
Michikawa M and Yanagisawa K Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. 1999 J. Neurochem. pmid:10349836
Weiss JF et al. Sterols with 29, 28 and 27 carbon atoms metabolically related to cholesterol, occurring in developing and mature brain. 1968 J. Neurochem. pmid:5675585
Schedin S et al. Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. 1995 J. Neurochem. pmid:7616223
Jones JP et al. The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats. 1975 J. Neurochem. pmid:1167373
Volpe JJ and Obert KA Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin. 1982 J. Neurochem. pmid:7062041
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Jeng I et al. Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A. 1984 J. Neurochem. pmid:6567656
Crick DC et al. Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. 1995 J. Neurochem. pmid:7643114
Heacock AM et al. Cholesterol synthesis and nerve regeneration. 1984 J. Neurochem. pmid:6699648
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of (2- 14 C)mevalonic acid into 30-day-old rat brain: a period of transition. 1972 J. Neurochem. pmid:5019590
Surup F et al. Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. 2015 J. Nat. Prod. pmid:25871540
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Itoh D et al. Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. 2000 J. Nat. Prod. pmid:10978203
Itoh D et al. Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. 2003 J. Nat. Prod. pmid:12662088
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Habeos IG et al. Simvastatin activates Keap1/Nrf2 signaling in rat liver. 2008 J. Mol. Med. pmid:18787804
Turunen M et al. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. 2000 J. Mol. Biol. pmid:10731415
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Brown GR et al. Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8709131
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Lakshmanan MR et al. Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone. 1968 J. Lipid Res. pmid:5650929
Rosenwald AG and Krag SS Lec9 CHO glycosylation mutants are defective in the synthesis of dolichol. 1990 J. Lipid Res. pmid:2111370
Brown MS and Goldstein JL Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. 1980 J. Lipid Res. pmid:6995544
Petras SF et al. HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. 1999 J. Lipid Res. pmid:9869647
Hickman PE et al. Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat. 1972 J. Lipid Res. pmid:5059193
Langdon R et al. Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol. 1977 J. Lipid Res. pmid:833506
Lefevre AF et al. Effect of ethanol on cholesterol and bile acid metabolism. 1972 J. Lipid Res. pmid:5059198
Kekki M et al. Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man. 1977 J. Lipid Res. pmid:833511
Honda A et al. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. 2007 J. Lipid Res. pmid:17272831
Gaskin F and Clayton RB An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. 1972 J. Lipid Res. pmid:4400581
Pfohl M et al. Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy. 1994 J. Lipid Res. pmid:7868973
Lüdke SM et al. Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2008 J. Lipid Res. pmid:18669481
Kopito RR et al. Metabolism of plasma mevalonate in rats and humans. 1982 J. Lipid Res. pmid:7097123
Stone BG and Evans CD Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver. 1992 J. Lipid Res. pmid:1464750
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Brannan PG et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots. 1975 J. Lipid Res. pmid:162931
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Johnson KA et al. In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge. 1994 J. Lipid Res. pmid:7897321
Thompson GR et al. Role of cholesterol in regulating apolipoprotein B secretion by the liver. 1996 J. Lipid Res. pmid:8728309
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN RAT AND GUINEA PIG LIVER IN VITRO. 1965 J. Lipid Res. pmid:14280469
Goldfarb S and Pitot HC Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase. 1972 J. Lipid Res. pmid:4641420
Pandak WM et al. Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis. 1990 J. Lipid Res. pmid:1708805
Kasim SE et al. Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat. 1992 J. Lipid Res. pmid:1552226
Schwartz CC et al. Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. 2004 J. Lipid Res. pmid:15145983
Pandak WM et al. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. 1990 J. Lipid Res. pmid:2313206
Erickson SK et al. Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats. 1989 J. Lipid Res. pmid:2614275
Raskin P and Siperstein MD Mevalonate metabolism by renal tissue in vitro. 1974 J. Lipid Res. pmid:4811213
Angelin B et al. Hepatic cholesterol metabolism in obesity: activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1982 J. Lipid Res. pmid:7119574
Gould RG and Swyryd EA Sites of control of hepatic cholesterol biosynthesis. 1966 J. Lipid Res. pmid:5971049
Elwood JC and Morris HP Lack of adaptation in lipogenesis by hepatoma 9121. 1968 J. Lipid Res. pmid:4296416
Holstein SA and Hohl RJ Monoterpene regulation of Ras and Ras-related protein expression. 2003 J. Lipid Res. pmid:12671036
Nicolau G et al. Determination of hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in man. 1974 J. Lipid Res. pmid:4811219
Gidez LI et al. Turnover of cholesteryl esters of plasma lipoproteins in the rat. 1967 J. Lipid Res. pmid:14564699
Ockner RK and Laster L Biosynthesis of delta-7-cholesten-3-beta-ol, delta-5,7-cholestadien-3-beta-ol, and delta-5-cholesten-3-beta-ol by guinea pig intestinal mucosa in vitro. 1966 J. Lipid Res. pmid:5971571
Saini GS et al. Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. 2006 J. Lipid Res. pmid:16861623
Barter PJ Origin of esterified cholesterol transported in the very low density lipoproteins of human plasma. 1974 J. Lipid Res. pmid:4359537
Björkhem I and Akerlund JE Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in rat liver. 1988 J. Lipid Res. pmid:3367083
Daly MM Biosynthesis of squalene and sterols by rat aorta. 1971 J. Lipid Res. pmid:5579265
Logan DM Thermal and pH stability of 2 -isopentenyl pyrophosphate. 1972 J. Lipid Res. pmid:4333821
Hinson DD et al. Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. 1997 J. Lipid Res. pmid:9392419
Tucker DE et al. Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. 2005 J. Lipid Res. pmid:16061942
GOODMAN DS and SHIRATORI T IN VIVO TURNOVER OF DIFFERENT CHOLESTEROL ESTERS IN RAT LIVER AND PLASMA. 1964 J. Lipid Res. pmid:14221103
Marais AD et al. Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. 1997 J. Lipid Res. pmid:9374129
Pappu AS et al. Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. 2006 J. Lipid Res. pmid:16983147
Wilson WK et al. Determination of the enantiomeric purity of mevalonolactone via NMR using a chiral lanthanide shift reagent. 1982 J. Lipid Res. pmid:7097129
Erickson SK et al. Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro. 1980 J. Lipid Res. pmid:7441061
Taddeini L et al. Acceleration of hepatic sterol synthesis after a single dose of the porphyrogenic chemical allylisopropylacetamide. 1974 J. Lipid Res. pmid:4811218
Klauda HC and Zilversmit DB Influx of cholesterol into plasma in rabbits with fasting hyperbetalipoproteinemia. 1974 J. Lipid Res. pmid:4372287
Zhang Z et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. 2001 J. Lipid Res. pmid:11290837