| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
| Peutz-Jeghers Syndrome | D010580 | 2 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
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All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bergès T et al. | The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity. | 1997 | J. Bacteriol. | pmid:9244250 |
| Risé P et al. | Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. | 1997 | J. Lipid Res. | pmid:9254057 |
| Naoumova RP et al. | Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. | 1997 | J. Lipid Res. | pmid:9254075 |
| Sakai M et al. | HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein. | 1997 | Atherosclerosis | pmid:9258407 |
| Cuthbert JA and Lipsky PE | Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism. | 1997 | Cancer Res. | pmid:9270019 |
| Meigs TE and Simoni RD | Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. | 1997 | Arch. Biochem. Biophys. | pmid:9281305 |
| El-Sohemy A and Archer MC | Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. | 1997 | Cancer Res. | pmid:9288773 |
| Knöss W et al. | Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. | 1997 | Biochem. J. | pmid:9291117 |
| Ren Z et al. | Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. | 1997 | Biochem. Pharmacol. | pmid:9296357 |
| Schwender J et al. | Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. | 1997 | FEBS Lett. | pmid:9305746 |
| Parmryd I et al. | Chloroplastic prenylated proteins. | 1997 | FEBS Lett. | pmid:9323028 |
| Potter D and Miziorko HM | Identification of catalytic residues in human mevalonate kinase. | 1997 | J. Biol. Chem. | pmid:9325256 |
| Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |
| Hinson DD et al. | Identification of an active site alanine in mevalonate kinase through characterization of a novel mutation in mevalonate kinase deficiency. | 1997 | J. Biol. Chem. | pmid:9334262 |
| pmid:9344354 | ||||
| Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
| Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
| Feillet C et al. | Cholesterol biosynthesis in normocholesterolemic patients after cholesterol removal by plasmapheresis. | 1997 | J Clin Apher | pmid:9365862 |
| Hampton RY and Bhakta H | Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9371780 |
| Hjertman M et al. | Evidence for protein dolichylation. | 1997 | FEBS Lett. | pmid:9373159 |
| Marais AD et al. | Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. | 1997 | J. Lipid Res. | pmid:9374129 |
| Forman BM et al. | The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9380679 |
| de Chaves EI et al. | Role of lipoproteins in the delivery of lipids to axons during axonal regeneration. | 1997 | J. Biol. Chem. | pmid:9388216 |
| pmid:9389491 | ||||
| Pahan K et al. | Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. | 1997 | J. Clin. Invest. | pmid:9389730 |
| Hinson DD et al. | Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. | 1997 | J. Lipid Res. | pmid:9392419 |
| Riches FM et al. | Direct association between the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 and plasma mevalonic acid and lathosterol concentrations in man. | 1997 | Atherosclerosis | pmid:9395276 |
| Ukai M et al. | Cholesterol synthesis in germfree and conventional rats. | 1976 | J. Nutr. | pmid:939998 |
| Dunzendorfer S et al. | Mevalonate-dependent inhibition of transendothelial migration and chemotaxis of human peripheral blood neutrophils by pravastatin. | 1997 | Circ. Res. | pmid:9400376 |
| Gadbut AP et al. | Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. | 1997 | EMBO J. | pmid:9405354 |
| Goto D et al. | Upregulation of low density lipoprotein receptor by gemfibrozil, a hypolipidemic agent, in human hepatoma cells through stabilization of mRNA transcripts. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409246 |
| pmid:942445 | ||||
| Tatsuno I et al. | Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9425279 |
| Bianchi C et al. | Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. | 1997 | J. Pediatr. | pmid:9427904 |
| pmid:9430371 | ||||
| Pfohl M et al. | Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect. | 1997 | Atherosclerosis | pmid:9430376 |
| Hrboticky N et al. | Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin. | 1997 | Biochim. Biophys. Acta | pmid:9434135 |
| Lala A et al. | Apolipoprotein E genotype and cholesterogenesis in polygenic hypercholesterolemia. | 1998 | Metab. Clin. Exp. | pmid:9440485 |
| Kwiterovich PO and Motevalli M | Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445257 |
| Kanayama N et al. | Genetic evaluation of physiological functions of thiolase isoenzymes in the n-alkalane-assimilating yeast Candida tropicalis. | 1998 | J. Bacteriol. | pmid:9457876 |
| Shamburek RD et al. | Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. | 1997 | J. Lipid Res. | pmid:9458266 |
| Natarajan R et al. | Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9480812 |
| Lange BM et al. | A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482845 |
| Ellsworth JL and Starr JR | Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. | 1998 | Metab. Clin. Exp. | pmid:9500571 |
| Sul D and Kaneshiro ES | Ubiquinone synthesis by Pneumocystis carinii: incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. | 1997 Nov-Dec | J. Eukaryot. Microbiol. | pmid:9508445 |
| Rosenthal RS and Rodwell VW | Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon. | 1998 | Protein Sci. | pmid:9514272 |
| Kalra VK and Blankenhorn DH | Abnormal activation of sterol synthesis in lymphocytes of atherosclerotic-susceptible pigeons and heterozygous familial hypercholesterolemic patients. | 1976 | Biochim. Biophys. Acta | pmid:952994 |
| Disch A et al. | Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. | 1998 | Biochem. J. | pmid:9531505 |
| Laufs U et al. | Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. | 1998 | Circulation | pmid:9537338 |
| Gopalaswamy UV and Aiyar AS | Actinomycin D-induced enhancement of ubiquinone biosynthesis in rat. | 1976 | Chem. Biol. Interact. | pmid:954142 |
| Luckman SP et al. | Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. | 1998 | J. Bone Miner. Res. | pmid:9556058 |
| Kaur M et al. | Receptor-Ck-dependent regulation of genes involved in the cell cycle. | 1998 | Mol. Cell. Biochem. | pmid:9562250 |
| Coutant KD et al. | Fluvastatin enhances receptor-stimulated intracellular Ca2+ release in human keratinocytes. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571146 |
| Visioli F et al. | Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells. | 1998 | Alcohol | pmid:9590514 |
| Orihara N et al. | Studies on the biosynthesis of terpenoidal compounds produced by actinomycetes. 2. Biosynthesis of carquinostatin B via the non-mevalonate pathway in Streptomyces exfoliatus. | 1997 | J. Antibiot. | pmid:9592576 |
| Singh I et al. | Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. | 1998 | FEBS Lett. | pmid:9600263 |
| Rubins JB et al. | Lovastatin induces apoptosis in malignant mesothelioma cells. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603146 |
| Crick DC et al. | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. | 1998 | J. Neurochem. | pmid:9603204 |
| Melnykovych G et al. | Inhibition of cholesterol biosynthesis in HeLa cells by glucocorticoids. | 1976 | Biochem. Biophys. Res. Commun. | pmid:962938 |
| Mitropoulos KA and Gibbons GF | Effect of triarimol on cholesterol biosynthesis in rat-liver subcellular. | 1976 | Biochem. Biophys. Res. Commun. | pmid:962959 |
| Aspbury RA et al. | Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. | 1998 | Biochim. Biophys. Acta | pmid:9630668 |
| Adam KP et al. | Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicum. | 1998 | Arch. Biochem. Biophys. | pmid:9633614 |
| Ramaswamy NK et al. | A novel pathway for the synthesis of solanidine in the isolated chloroplast from greening potatoes. | 1976 | Eur. J. Biochem. | pmid:964241 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Nishio E et al. | Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. | 1998 | Eur. J. Pharmacol. | pmid:9650858 |
| Disch A et al. | Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. | 1998 | Biochem. J. | pmid:9657979 |
| Rieder C et al. | Biosynthesis of the diterpene verrucosan-2beta-ol in the phototrophic eubacterium Chloroflexus aurantiacus. A retrobiosynthetic NMR study. | 1998 | J. Biol. Chem. | pmid:9660767 |
| Kashiwagi Y et al. | Mechanical stretch activates a pathway linked to mevalonate metabolism in cultured neonatal rat heart cells. | 1998 | Hypertens. Res. | pmid:9661807 |
| Yan D et al. | Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). | 1998 | J. Biol. Chem. | pmid:9677393 |
| Kitahara M et al. | NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. | 1998 | Jpn. J. Pharmacol. | pmid:9681568 |
| Pfohl M et al. | Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions. | 1998 | Eur. J. Clin. Invest. | pmid:9693942 |
| pmid:9703948 | ||||
| Takahashi S et al. | A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9707569 |
| Hinson DD et al. | Hematological abnormalities and cholestatic liver disease in two patients with mevalonate kinase deficiency. | 1998 | Am. J. Med. Genet. | pmid:9714005 |
| Laufs U and Liao JK | Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. | 1998 | J. Biol. Chem. | pmid:9727051 |
| Orihara N et al. | Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus. | 1998 | J. Antibiot. | pmid:9727394 |
| Guijarro C et al. | 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. | 1998 | Circ. Res. | pmid:9734471 |
| Harrison LE et al. | Phenylacetate inhibits isoprenoid biosynthesis and suppresses growth of human pancreatic carcinoma. | 1998 | Surgery | pmid:9736908 |
| Takeuchi N et al. | Feed-back control of cholesterol synthesis in partially hepatectomized rats. | 1976 | Biochim. Biophys. Acta | pmid:974156 |
| Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
| Hiramatsu M et al. | Enzyme immunoassay of urinary mevalonic acid and its clinical application. | 1998 | Clin. Chem. | pmid:9761249 |
| Coxon FP et al. | Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. | 1998 | Mol. Pharmacol. | pmid:9765505 |
| Ogura M et al. | Further studies on the possible compartmentation of the precursor pool of cholesterol for the biosynthesis of cholic acid in the rat. | 1976 | J. Biochem. | pmid:977552 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. | 1998 | J. Neurosci. Res. | pmid:9778150 |
| Naoumova RP et al. | Cholesterol synthesis is increased in mixed hyperlipidaemia. | 1998 | Biochim. Biophys. Acta | pmid:9795192 |
| Schedin S et al. | Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. | 1998 | Biochim. Biophys. Acta | pmid:9795206 |
| Lamb DC et al. | A sterol biosynthetic pathway in Mycobacterium. | 1998 | FEBS Lett. | pmid:9804188 |
| Disch A and Rohmer M | On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. | 1998 | FEMS Microbiol. Lett. | pmid:9835029 |
| Shipman CM et al. | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | 1998 | Cancer Res. | pmid:9850051 |
| Wellburn AR and Hampp R | Uptake of mevalonate and acetate during plastid development. | 1976 | Biochem. J. | pmid:985424 |
| Melichar B et al. | Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. | 1998 | Clin. Cancer Res. | pmid:9865922 |
| Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
| Petras SF et al. | HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. | 1999 | J. Lipid Res. | pmid:9869647 |
| pmid:9872842 | ||||
| Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
| pmid:9882513 | ||||
| pmid:990276 | ||||
| pmid:9920100 | ||||
| Nishimura M et al. | Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. | 1999 | Kidney Int. | pmid:9987076 |