Liu JC et al. |
The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. |
2002 |
Am. J. Chin. Med. |
pmid:12568290
|
|
|
|
|
pmid:12605351
|
Masamura K et al. |
Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. |
2003 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12615662
|
De-Eknamkul W and Potduang B |
Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. |
2003 |
Phytochemistry |
pmid:12620352
|
Righetti M et al. |
The in vitro metabolism of mevalonate by sterol and non-sterol pathways. |
1976 |
J. Biol. Chem. |
pmid:1262340
|
Aktas O et al. |
Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. |
2003 |
J. Exp. Med. |
pmid:12629065
|
Laufs U |
Beyond lipid-lowering: effects of statins on endothelial nitric oxide. |
2003 |
Eur. J. Clin. Pharmacol. |
pmid:12634978
|
|
|
|
|
pmid:12636409
|
Poirier J |
Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. |
2003 |
Trends Mol Med |
pmid:12657430
|
Abernethy D et al. |
In vitro inhibition of rat liver cholest-5en-3 beta-ol (cholesterol) biosynthesis by non-mercurial sulfhydryl reagents. |
1976 |
Steroids |
pmid:1265795
|
Itoh D et al. |
Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. |
2003 |
J. Nat. Prod. |
pmid:12662088
|
Luan Z et al. |
Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. |
2003 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12663370
|
Awad AB et al. |
Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. |
2003 |
J. Nutr. Biochem. |
pmid:12667603
|
Holstein SA and Hohl RJ |
Monoterpene regulation of Ras and Ras-related protein expression. |
2003 |
J. Lipid Res. |
pmid:12671036
|
|
|
|
|
pmid:12677167
|
|
|
|
|
pmid:12677170
|
Suzuki K |
Effects of S-8527 (1,1-bis(4'-(1'-carboxy-1'-methylpropoxy)phenyl) cyclohexane), a new hypolipidemic compound, on cholesterol and lipoprotein metabolism in rats. |
1976 |
Biochem. Pharmacol. |
pmid:1267828
|
|
|
|
|
pmid:12693933
|
Grabińska K and Palamarczyk G |
Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. |
2002 |
FEMS Yeast Res. |
pmid:12702274
|
Hemmerlin A et al. |
Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. |
2003 |
J. Biol. Chem. |
pmid:12736259
|
Iguchi T et al. |
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. |
2003 |
Cell. Signal. |
pmid:12742232
|
Haslinger B et al. |
Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. |
2003 |
Kidney Int. |
pmid:12753293
|
|
|
|
|
pmid:12773152
|
|
|
|
|
pmid:12778056
|
Hong SB et al. |
Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. |
2003 May-Jun |
Biotechnol. Prog. |
pmid:12790690
|
|
|
|
|
pmid:12792788
|
|
|
|
|
pmid:12796698
|
|
|
|
|
pmid:12798327
|
Silber JR et al. |
The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. |
1992 |
Biochem. J. |
pmid:1281982
|
Hall FC |
Put your heart into the joint benefits of statins! |
2003 |
Arthritis Res. Ther. |
pmid:12823851
|
Zheng YH et al. |
Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12824470
|
Houten SM et al. |
Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. |
2003 |
Cell. Mol. Life Sci. |
pmid:12861380
|
Vamvakopoulos JE and Green C |
HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. |
2003 |
BMC Cardiovasc Disord |
pmid:12871602
|
|
|
|
|
pmid:12872277
|
Töyräs A et al. |
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. |
2003 |
Eur J Pharm Sci |
pmid:12885386
|
Laufs U and Liao JK |
Isoprenoid metabolism and the pleiotropic effects of statins. |
2003 |
Curr Atheroscler Rep |
pmid:12911847
|
Bank I et al. |
Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen. |
2003 |
Cell. Immunol. |
pmid:12914756
|
|
|
|
|
pmid:12914758
|
Ohashi K et al. |
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. |
2003 |
J. Biol. Chem. |
pmid:12920113
|
Meyers CD et al. |
Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. |
2003 |
J. Lipid Res. |
pmid:12923222
|
Monick MM et al. |
Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. |
2003 |
J. Immunol. |
pmid:12928415
|
|
|
|
|
pmid:12941308
|
Blanco-Colio LM et al. |
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes. |
2003 |
Circulation |
pmid:12952848
|
|
|
|
|
pmid:12953163
|
Giricz Z et al. |
Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. |
2003 |
Basic Res. Cardiol. |
pmid:12955403
|
|
|
|
|
pmid:12957384
|
Shi J et al. |
Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. |
2003 |
Blood Coagul. Fibrinolysis |
pmid:12960612
|
|
|
|
|
pmid:12963986
|
Shiota Y et al. |
Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. |
2003 |
J. Biochem. |
pmid:12966067
|
|
|
|
|
pmid:12969437
|
|
|
|
|
pmid:1308625
|
Bokoch GM and Prossnitz V |
Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. |
1992 |
J. Clin. Invest. |
pmid:1310693
|
Khosravi-Far R et al. |
Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct. |
1992 |
J. Biol. Chem. |
pmid:1332953
|
HONG L and WRIGHT LD |
Paper chromatography of mevalonate and acetate. |
1957 |
Biochim. Biophys. Acta |
pmid:13479486
|
Buchwald H |
Cholesterol inhibition, cancer, and chemotherapy. |
1992 |
Lancet |
pmid:1349377
|
|
|
|
|
pmid:1353519
|
Sunazuka T et al. |
Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase. |
1992 |
J. Antibiot. |
pmid:1355474
|
PARK RB and BONNER J |
Enzymatic synthesis of rubber from mevalonic acid. |
1958 |
J. Biol. Chem. |
pmid:13563498
|
GOODWIN TW |
Studies in carotenogenesis. 25. The incorporation of 14CO2, [2-14C] acetate and [2-14C]mevalonate into beta-carotene by illuminated etiolated maize seedings. |
1958 |
Biochem. J. |
pmid:13607416
|
MARKLEY K and GURIN S |
Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. |
1959 |
Biochim. Biophys. Acta |
pmid:13628647
|
GOSSELIN L and POPJAK G |
Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid. |
1959 |
Biochem. J. |
pmid:13651113
|
PURCELL AE et al. |
The incorporation of mevalonic acid into tomato carotenoids. |
1959 |
J. Biol. Chem. |
pmid:13654323
|
RILLING HC and BLOCH K |
On the mechanism of squaiene biogenesis from mevalonic acid. |
1959 |
J. Biol. Chem. |
pmid:13654391
|
|
|
|
|
pmid:13727607
|
POPJAK G et al. |
Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. |
1961 |
J. Biol. Chem. |
pmid:13737104
|
|
|
|
|
pmid:13739420
|
SCHLESINGER MJ and COON MJ |
Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver. |
1961 |
J. Biol. Chem. |
pmid:13747804
|
SHAH SN et al. |
The effect of growth hormone administration and dietary protein on the incorporation of sodium acetate-2-C14 and mevalonic acid-2-C14 into liver cholesterol. |
1961 |
Arch. Biochem. Biophys. |
pmid:13750592
|
TADA M and LYNEN F |
[On the biosynthesis of terpenes. XIV. On the determination of phosphomevalonic acid kinase and pyrophosphomevalonic acid decarboxylase in cell extracts]. |
1961 |
J. Biochem. |
pmid:13774769
|
Schafer BL et al. |
Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria. |
1992 |
J. Biol. Chem. |
pmid:1377680
|
|
|
|
|
pmid:13793365
|
BLOCH K et al. |
Mevalonic acid pyrophosphate and isopentenylpyrophosphate. |
1959 |
J. Biol. Chem. |
pmid:13801508
|
DE WAARD A and POPJAK G |
Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations. |
1959 |
Biochem. J. |
pmid:13815126
|
DURR IF and RUDNEY H |
The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. |
1960 |
J. Biol. Chem. |
pmid:13818862
|
ELWOOD JC et al. |
Lipid metabolism in the diabetic rat. IV. Metabolism of acetate, acetoacetate, butyrate, and mevalonate in vitro. |
1960 |
J. Biol. Chem. |
pmid:13820133
|
GARATTINI S et al. |
Lipid biosynthesis in vivo from acetate-1-C 14 and 2-C 14 and mevalonic-2-C 14 acid. |
1959 |
Arch. Biochem. Biophys. |
pmid:13826357
|
WITTING LA and PORTER JW |
Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. |
1959 |
J. Biol. Chem. |
pmid:13845505
|
BRAITHWAITE GD and GOODWIN TW |
Studies in carotenogenesis. 26. The incorporation of [C14] acetate, [C14] mevalonate and C14-labelled carbon dioxide into beta-carotene by the fungus Phycomyces blakesleeanus. |
1960 |
Biochem. J. |
pmid:13849152
|
BRAITHWAITE GD and GOODWIN TW |
Studies in carotenogenesis. 27. Incorporation of [2-14C] acetate, DL-[2-14C] mevalonate and C14-labelled carbon dioxide into carrotroot preparations. |
1960 |
Biochem. J. |
pmid:13849153
|
NICHOLAS HJ and THOMAS BE |
Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. |
1959 |
Biochim. Biophys. Acta |
pmid:13854106
|
|
|
|
|
pmid:13874154
|
Manzi P et al. |
Seasonal commitment of HMGCoA reductase activity to vitellogenin production. |
1992 |
Biosci. Rep. |
pmid:1391685
|
|
|
|
|
pmid:13921034
|
|
|
|
|
pmid:13921035
|
|
|
|
|
pmid:13921036
|
OHNOKI D et al. |
D5-Phosphomevalonic acid as the intermediate of the enzymatic synthesis of bacterial phytoene. |
1962 |
J. Biochem. |
pmid:13939688
|
GAYLOR JL |
Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. |
1963 |
Arch. Biochem. Biophys. |
pmid:13946925
|
GOODMAN DS et al. |
Studies of cholesterol biosynthesis. V. The time course and pathway of the later stages of cholesterol biosynthesis in the livers of intact rats. |
1963 |
J. Biol. Chem. |
pmid:13949089
|
FUMAGALLI R et al. |
Cholesterol synthesis in rat brain: differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14. |
1962 |
Arch. Biochem. Biophys. |
pmid:13960261
|
BEELER DA et al. |
The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. |
1963 |
Arch. Biochem. Biophys. |
pmid:13970235
|
|
|
|
|
pmid:13970858
|
Adamson P et al. |
Post-translational modifications of p21rho proteins. |
1992 |
J. Biol. Chem. |
pmid:1400319
|
|
|
|
|
pmid:14011505
|
BRODIE JD et al. |
The participation of malonyl coenzyme A in the biosynthesis of mevalonic acid. |
1963 |
J. Biol. Chem. |
pmid:14015675
|
RAMASARMA T and RAMAKRISHNAN T |
Incorporation of [2-14C]mevalonic acid and [2-14C]acetic acid into lipids of mycobacteria. |
1961 |
Biochem. J. |
pmid:14038591
|
|
|
|
|
pmid:14039712
|
|
|
|
|
pmid:14065977
|
PORTMAN OW and SUGANO M |
THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. |
1963 |
Arch. Biochem. Biophys. |
pmid:14072510
|
DALY MM et al. |
CHOLESTEROL CONCENTRATION AND CHOLESTEROL SYNTHESIS IN AORTAS OF RATS WITH RENAL HYPERTENSION. |
1963 |
J. Clin. Invest. |
pmid:14074354
|
TERNER C and KORSH G |
THE BIOSYNTHESIS OF GLYCERIDES IN HOMOGENATES OF NORMAL LACTATING MAMMARY GLAND AND OF MAMMARY TUMOR TISSUE OF THE MOUSE. |
1963 |
Cancer Res. |
pmid:14079150
|