Paradisi M et al. |
Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. |
2005 |
BMC Cell Biol. |
pmid:15982412
|
|
|
|
|
pmid:1598578
|
|
|
|
|
pmid:15996638
|
|
|
|
|
pmid:16019076
|
|
|
|
|
pmid:16019130
|
Saiki A et al. |
Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. |
2005 |
J. Atheroscler. Thromb. |
pmid:16020917
|
Baker SK and Tarnopolsky MA |
Statin-associated neuromyotoxicity. |
2005 |
Drugs Today |
pmid:16034491
|
Donovan JM et al. |
Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. |
2005 |
Dig. Dis. Sci. |
pmid:16047465
|
Hargreaves IP et al. |
The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. |
2005 |
Drug Saf |
pmid:16048353
|
Luckman SP et al. |
JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). |
2005 |
J. Bone Miner. Res. |
pmid:16050006
|
|
|
|
|
pmid:16051251
|
Bocci G et al. |
Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. |
2005 |
Br. J. Cancer |
pmid:16052215
|
van Heusden GP et al. |
Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes. |
1992 |
Biochim. Biophys. Acta |
pmid:1606178
|
Tucker DE et al. |
Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. |
2005 |
J. Lipid Res. |
pmid:16061942
|
Caruso MG and Notarnicola M |
Biochemical changes of mevalonate pathway in human colorectal cancer. |
2005 Sep-Oct |
Anticancer Res. |
pmid:16101154
|
Girlanda S et al. |
MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. |
2005 |
Cancer Res. |
pmid:16103105
|
Duncan RE et al. |
Statins and cancer development. |
2005 |
Cancer Epidemiol. Biomarkers Prev. |
pmid:16103434
|
Luebker DJ et al. |
Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters. |
2005 |
Toxicology |
pmid:16129535
|
Subden RE and Renaud RL |
Isolation of 4 alpha-methyl-5 alpha-ergosta-8,24(28)-dien-3 beta-ol from ester fractions of nutritionally deprived Neurospora crassa. |
1979 |
Steroids |
pmid:161433
|
Viereck V et al. |
Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. |
2005 |
J. Cell. Biochem. |
pmid:16152630
|
Zeng L et al. |
HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. |
2005 |
FASEB J. |
pmid:16160062
|
van Beek E et al. |
Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. |
2006 |
Bone |
pmid:16165408
|
|
|
|
|
pmid:1616923
|
Thompson K et al. |
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. |
2006 |
Blood |
pmid:16179378
|
Graber SG et al. |
Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system. |
1992 |
J. Biol. Chem. |
pmid:1618813
|
Meigs TE and Simoni RD |
Regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in permeabilized cells. |
1992 |
J. Biol. Chem. |
pmid:1618856
|
Pandak WM et al. |
Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. |
1992 |
J. Lipid Res. |
pmid:1619360
|
Hamadmad SN et al. |
Erythropoietin receptor signal transduction requires protein geranylgeranylation. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16203826
|
Bevilacqua M et al. |
Bisphosphonates and atherosclerosis: why? |
2005 |
Lupus |
pmid:16218486
|
Murthy S et al. |
Regulation of fatty acid synthesis by farnesyl pyrophosphate. |
2005 |
J. Biol. Chem. |
pmid:16221687
|
Kim J et al. |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. |
2005 |
J. Chem. Ecol. |
pmid:16222778
|
Balasubramaniam S et al. |
Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. |
1977 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16260
|
Nair AK and Menon KM |
Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. |
2005 |
J. Biol. Chem. |
pmid:16263716
|
|
|
|
|
pmid:16268586
|
Qin W et al. |
Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. |
1992 |
Biochim. Biophys. Acta |
pmid:1627634
|
Brannan PG et al. |
3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots. |
1975 |
J. Lipid Res. |
pmid:162931
|
Pronin AN and Gautam N |
Interaction between G-protein beta and gamma subunit types is selective. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1631113
|
Bejarano ER and Cerdá-Olmedo E |
Independence of the carotene and sterol pathways of Phycomyces. |
1992 |
FEBS Lett. |
pmid:1633878
|
Boyle PJ et al. |
Role of GH in regulating nocturnal rates of lipolysis and plasma mevalonate levels in normal and diabetic humans. |
1992 |
Am. J. Physiol. |
pmid:1636694
|
González-Fernández L et al. |
Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. |
2006 |
FEBS J. |
pmid:16367743
|
Seong K et al. |
Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. |
2006 |
Fungal Genet. Biol. |
pmid:16377218
|
Rattan R et al. |
Rho/ROCK pathway as a target of tumor therapy. |
2006 |
J. Neurosci. Res. |
pmid:16385577
|
Reimann FM et al. |
Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells. |
1992 |
Digestion |
pmid:1639221
|
Kanellis J et al. |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. |
2006 |
Immunol. Cell Biol. |
pmid:16405649
|
Christensen M et al. |
Simvastatin protection against acute immune-mediated glomerulonephritis in mice. |
2006 |
Kidney Int. |
pmid:16407885
|
Ramasubbu K and Mann DL |
The emerging role of statins in the treatment of heart failure. |
2006 |
J. Am. Coll. Cardiol. |
pmid:16412858
|
Gómez-Hernández A et al. |
Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. |
2006 |
J. Cardiovasc. Pharmacol. |
pmid:16424787
|
|
|
|
|
pmid:1642695
|
Henry A et al. |
Fibric acid derivatives: effects on the synthesis of isoprenoid lipids in cultured human lymphocytes. |
1992 |
Biochim. Biophys. Acta |
pmid:1643103
|
|
|
|
|
pmid:16435209
|
Nagashima T et al. |
Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. |
2006 |
Arthritis Rheum. |
pmid:16447234
|
Riganti C et al. |
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. |
2006 |
Int. J. Cancer |
pmid:16450390
|
Kawasaki T et al. |
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. |
2006 |
J. Bacteriol. |
pmid:16452404
|
Ridsdale A et al. |
Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. |
2006 |
Mol. Biol. Cell |
pmid:16452637
|
|
|
|
|
pmid:16454747
|
Polo MP and de Bravo MG |
Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. |
2006 |
Biochem. Cell Biol. |
pmid:16462894
|
|
|
|
|
pmid:16475974
|
|
|
|
|
pmid:16477420
|
Hampel D et al. |
Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. |
2006 |
J. Agric. Food Chem. |
pmid:16478276
|
|
|
|
|
pmid:16483650
|
Khosravi-Far R et al. |
Isoprenoid modification of rab proteins terminating in CC or CXC motifs. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1648736
|
|
|
|
|
pmid:1648935
|
Hidaka Y et al. |
Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. |
1991 |
J. Biol. Chem. |
pmid:1649182
|
Xu L et al. |
[Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. |
2006 |
Nan Fang Yi Ke Da Xue Xue Bao |
pmid:16503530
|
|
|
|
|
pmid:16503719
|
Kotti TJ et al. |
Brain cholesterol turnover required for geranylgeraniol production and learning in mice. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16505352
|
Benetka W et al. |
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. |
2006 |
BMC Biochem. |
pmid:16507103
|
Li JQ et al. |
Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. |
2006 |
Clin. Chim. Acta |
pmid:16507303
|
|
|
|
|
pmid:16507758
|
Chana RS and Brunskill NJ |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. |
2006 |
Am. J. Nephrol. |
pmid:16508249
|
Yokota K et al. |
Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. |
2006 |
J. Rheumatol. |
pmid:16511915
|
Qiu Y and Li D |
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. |
2006 |
Org. Lett. |
pmid:16524256
|
Hoffmann GF et al. |
Facts and artefacts in mevalonic aciduria: development of a stable isotope dilution GCMS assay for mevalonic acid and its application to physiological fluids, tissue samples, prenatal diagnosis and carrier detection. |
1991 |
Clin. Chim. Acta |
pmid:1653652
|
Yoon SH et al. |
Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. |
2006 |
Biotechnol. Bioeng. |
pmid:16547999
|
Henry A et al. |
Dolichol biosynthesis in human malignant cells. |
1991 |
Biochem. J. |
pmid:1654890
|
Piotrowski PC et al. |
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. |
2006 |
Biol. Reprod. |
pmid:16571871
|
|
|
|
|
pmid:16575254
|
Mayer RJ et al. |
Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells. |
1991 |
J. Biol. Chem. |
pmid:1657912
|
Neville-Webbe HL et al. |
Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. |
2006 |
Tumour Biol. |
pmid:16582586
|
Ng LL and Davies JE |
HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts. |
1991 |
Am. J. Physiol. |
pmid:1659206
|
Wang J et al. |
Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. |
2006 |
Biol. Pharm. Bull. |
pmid:16595893
|
Patel NV and Forman BM |
Linking lipids, Alzheimer's and LXRs? |
2004 |
Nucl Recept Signal |
pmid:16604185
|
Ro DK et al. |
Production of the antimalarial drug precursor artemisinic acid in engineered yeast. |
2006 |
Nature |
pmid:16612385
|
Grochowski LL et al. |
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. |
2006 |
J. Bacteriol. |
pmid:16621811
|
Coward WR et al. |
Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. |
2006 |
J. Immunol. |
pmid:16621994
|
Qiu Y and Li D |
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. |
2006 |
Biochim. Biophys. Acta |
pmid:16626865
|
|
|
|
|
pmid:16630152
|
Braun PE et al. |
Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes. |
1991 |
J. Neurosci. Res. |
pmid:1666129
|
Silvander M et al. |
A new water-based topical carrier with polar skin-lipids. |
2006 |
Lipids Health Dis |
pmid:16672068
|
Hayman EP et al. |
Mechanism of the isomerization of isopentenyl pyrophosphate in Rhodotorual rubra-1. |
1975 |
J. Bacteriol. |
pmid:166981
|
|
|
|
|
pmid:16712874
|
|
|
|
|
pmid:16716369
|
Chemler JA et al. |
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. |
2006 |
Microb. Cell Fact. |
pmid:16719921
|
Solito E et al. |
Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. |
2006 |
FASEB J. |
pmid:16720734
|
Haas D and Hoffmann GF |
Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. |
2006 |
Orphanet J Rare Dis |
pmid:16722536
|
Sakoda K et al. |
Simvastatin decreases IL-6 and IL-8 production in epithelial cells. |
2006 |
J. Dent. Res. |
pmid:16723648
|
|
|
|
|
pmid:16733454
|
|
|
|
|
pmid:16735695
|
Jakóbisiak M et al. |
Cell cycle-specific effects of lovastatin. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1673788
|
Saha RN and Pahan K |
Regulation of inducible nitric oxide synthase gene in glial cells. |
2006 May-Jun |
Antioxid. Redox Signal. |
pmid:16771683
|