Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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Authors Title Published Journal PubMed Link
Ichiki T et al. Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11742861
Loregger A et al. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28882874
Lachmann HJ and Hawkins PN Developments in the scientific and clinical understanding of autoinflammatory disorders. 2009 Arthritis Res. Ther. pmid:19232070
Kinderlerer AR et al. Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. 2006 Arthritis Res. Ther. pmid:16859540
McCarey DW et al. Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? 2005 Arthritis Res. Ther. pmid:15743490
Hall FC Put your heart into the joint benefits of statins! 2003 Arthritis Res. Ther. pmid:12823851
Frenkel J et al. Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. 2002 Arthritis Rheum. pmid:12384940
Mandey SH et al. A role for geranylgeranylation in interleukin-1beta secretion. 2006 Arthritis Rheum. pmid:17075828
Nagashima T et al. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. 2006 Arthritis Rheum. pmid:16447234
Stojanov S et al. Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. 2004 Arthritis Rheum. pmid:15188372
Maxwell RE et al. Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats. 1983 Atherosclerosis pmid:6579963
Gleeson JM et al. Plasma apolipoprotein E, high density lipoprotein1 (HDL1) and urinary mevalonate excretion in pancreatectomized diabetic dogs: effects of insulin and lovastatin. 1990 Atherosclerosis pmid:2248616
Paris D et al. Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. 2002 Atherosclerosis pmid:11888511
Blanco-Colio LM et al. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. 2002 Atherosclerosis pmid:11882313
Guyton JR et al. Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 1995 Atherosclerosis pmid:8770318
Miettinen TA Mode of action of a new hypocholesteraemic drug (DH-581) in familial hypercholesteraemia. 1972 Mar-Apr Atherosclerosis pmid:4666121
Naoumova RP et al. Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia. 1996 Atherosclerosis pmid:8808497
Pfohl M et al. Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect. 1997 Atherosclerosis pmid:9430376
Sakai M et al. HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein. 1997 Atherosclerosis pmid:9258407
Illingworth DR et al. Increased urinary mevalonic acid excretion in patients with abetalipoproteinemia and homozygous hypobetalipoproteinemia. 1989 Atherosclerosis pmid:2920062
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Kaneta S et al. All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. 2003 Atherosclerosis pmid:14612203
Riches FM et al. Direct association between the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 and plasma mevalonic acid and lathosterol concentrations in man. 1997 Atherosclerosis pmid:9395276
Raal FJ et al. Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. 2000 Atherosclerosis pmid:10856535
Ahmed AA et al. Effect of milk constituents on hepatic cholesterol-genesis. 1979 Atherosclerosis pmid:465119
Cighetti G et al. Effects of pantethine on cholesterol synthesis from mevalonate in isolated rat hepatocytes. 1986 Atherosclerosis pmid:3707674
Sodhi HS et al. Separate pools for endogenous and exogenous cholesterol in rat intestines. 1973 Mar-Apr Atherosclerosis pmid:4709120
Hu W et al. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. 2012 Atherosclerosis pmid:22503826
Allen KG and Klevay LM Copper deficiency and cholesterol metabolism in the rat. 1978 Atherosclerosis pmid:718736
Martin-Ventura JL et al. LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. 2008 Atherosclerosis pmid:18378243
Ness GC et al. Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in allylamine-fed rats. 1974 Mar-Apr Atherosclerosis pmid:4855897
Kreuzer J et al. Chemotaxis of the monocyte cell line U937: dependence on cholesterol and early mevalonate pathway products. 1991 Atherosclerosis pmid:1759991
Stout RW The effect of insulin and glucose on sterol synthesis in cultured rat arterial smooth muscle cells. 1977 Atherosclerosis pmid:901624
Scoppola A et al. Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. 2001 Atherosclerosis pmid:11395032
Sodhi HS et al. Hypocholesterolemic agents and mobilization of tissue cholesterol in man. 1973 Jan-Feb Atherosclerosis pmid:4696743
Reimann FM et al. Reduced cholesterol esterification in CaCo-2 cells by indirect action of pravastatin. 1996 Atherosclerosis pmid:8831928
Ranganathan S et al. Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. 1982 Atherosclerosis pmid:7150392
Bernini F et al. Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. 1993 Atherosclerosis pmid:8141843
Dull BJ et al. The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone. 1983 Atherosclerosis pmid:6661267
Feillet C et al. Comparative effects of simvastatin and pravastatin on cholesterol synthesis in patients with primary hypercholesterolemia. 1995 Atherosclerosis pmid:8770319
Massey LK et al. Branched-chain amino acid catabolism in bacteria. 1976 Bacteriol Rev pmid:773366
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
Yang L et al. [Effects of clinically effective dose of lovastatin on prostate cancer PC3 cells]. 2010 Beijing Da Xue Xue Bao pmid:20721249
Rydgren T and Sandler S The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. 2009 Biochem. Biophys. Res. Commun. pmid:19150339
Blomquist GJ et al. Biosynthesis of 3-methylpentacosane in the cockroach Periplaneta americana. 1975 Biochem. Biophys. Res. Commun. pmid:1147933
Natarajan R et al. Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. 1998 Biochem. Biophys. Res. Commun. pmid:9480812
Latruffe N et al. Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells. 1995 Biochem. Biophys. Res. Commun. pmid:7503722
Ramsey RB et al. The effect of non-ionic detergents and phospholipase A on enzymes involved in adult rat brain sterol biosynthesis from (2-14C)-mevalonic acid in vitro. 1974 Biochem. Biophys. Res. Commun. pmid:4441393
Keung WM Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism. 1991 Biochem. Biophys. Res. Commun. pmid:1993065
Wiss O Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. 1976 Biochem. Biophys. Res. Commun. pmid:1252232
Hjertman M et al. Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. 2001 Biochem. Biophys. Res. Commun. pmid:11676505
Al-Haidari AA et al. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. 2014 Biochem. Biophys. Res. Commun. pmid:24582560
Sinensky M Isolation of a mammalian cell mutant resistant to 25-hydroxy cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:911332
Fogelman AM et al. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. 1977 Biochem. Biophys. Res. Commun. pmid:869944
Hatanaka H et al. Accumulation of a sterol intermediate during reaction in the presence of homocysteine with cell-free extract of yeast. 1974 Biochem. Biophys. Res. Commun. pmid:4608604
Ramachandran CK and Shah SN Decarboxylation of mevalonate pyrophosphate is one rate-limiting step in hepatic cholesterol synthesis in suckling and weaned rats. 1976 Biochem. Biophys. Res. Commun. pmid:177019
Sauane M et al. Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. 2004 Biochem. Biophys. Res. Commun. pmid:14706631
Amin D et al. Lovastatin is hypertriglyceridemic in Syrian golden hamsters. 1988 Biochem. Biophys. Res. Commun. pmid:3202864
Melnykovych G et al. Inhibition of cholesterol biosynthesis in HeLa cells by glucocorticoids. 1976 Biochem. Biophys. Res. Commun. pmid:962938
Fuse M et al. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. 2004 Biochem. Biophys. Res. Commun. pmid:14985133
Mitropoulos KA and Gibbons GF Effect of triarimol on cholesterol biosynthesis in rat-liver subcellular. 1976 Biochem. Biophys. Res. Commun. pmid:962959
Mbaya B et al. Isoprenoid metabolism in Plasmodium falciparum during the intraerythrocytic phase of malaria. 1990 Biochem. Biophys. Res. Commun. pmid:2268347
Maziere C et al. Cyclic AMP decreases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2. 1988 Biochem. Biophys. Res. Commun. pmid:2845980
Nes WD et al. Metabolism of mevalonic acid to long chain fatty alcohols in an insect. 1982 Biochem. Biophys. Res. Commun. pmid:7181890
Coutant KD et al. Fluvastatin enhances receptor-stimulated intracellular Ca2+ release in human keratinocytes. 1998 Biochem. Biophys. Res. Commun. pmid:9571146
Caravaca J and May MD The isolation and properties of an active peroxidase from hepatocatalase. 1964 Biochem. Biophys. Res. Commun. pmid:4380864
Rao GS and Ramasarma T ATP in the regulation of cholesterol biosynthesis- a supra-energetic role. 1972 Biochem. Biophys. Res. Commun. pmid:5077855
Florin-Christensen M et al. Occurrence of specific sterols in Pneumocystis carinii. 1994 Biochem. Biophys. Res. Commun. pmid:8292026
Anant JS and Fung BK In vivo farnesylation of rat rhodopsin kinase. 1992 Biochem. Biophys. Res. Commun. pmid:1550556
Krishnaiah KV et al. Regulation of steroidogenesis by ubiquinone. 1967 Biochem. Biophys. Res. Commun. pmid:6052477
Wang Y et al. 24S,25-Epoxycholesterol in mouse and rat brain. 2014 Biochem. Biophys. Res. Commun. pmid:24832732
Hornby GM et al. The effects of thiols on cholesterol synthesis by rat liver in vitro. 1970 Biochem. Biophys. Res. Commun. pmid:5492149
Heintz R et al. Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant. 1972 Biochem. Biophys. Res. Commun. pmid:4344813
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Chan PC et al. Lovastatin increases surface low density lipoprotein receptor expression by retarding the receptor internalization rate in proliferating lymphocytes. 1997 Biochem. Biophys. Res. Commun. pmid:9196047
Müller-Wieland D et al. Melatonin inhibits LDL receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes. 1994 Biochem. Biophys. Res. Commun. pmid:8074686
Aiyar AS et al. Biogenesis of ubiquinone in rats--an alternate origin of the benzoquinone moiety. 1971 Biochem. Biophys. Res. Commun. pmid:5117559
Haro D et al. Rat liver HMG CoA reductase, a glycoprotein of the endoplasmic reticulum, is in equilibrium between monomeric and dimeric forms. 1985 Biochem. Biophys. Res. Commun. pmid:3933506
Baisted DJ et al. The effect of cyclic triterpenes on cholesterol synthesis from mevalonate in rat liver homogenates. 1967 Biochem. Biophys. Res. Commun. pmid:6076231
Barr RM and De Luca LM The in vivo incorporation of mannose, retinol and mevalonic acid into phospholipids of hamster liver. 1974 Biochem. Biophys. Res. Commun. pmid:4421270
Szkopińska A et al. The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. 2000 Biochem. Biophys. Res. Commun. pmid:10623644
Sagami H et al. Novel isoprenoid modified proteins in Halobacteria. 1994 Biochem. Biophys. Res. Commun. pmid:8093082
Granzow C et al. Synthesis of lipids, cholesterol precursors and cholesterol in glycogen-free and glycogen-synthesizing sublines of the Ehrlich ascites tumor. 1975 Biochem. Biophys. Res. Commun. pmid:1164435
Tabacik C et al. Cholesterogenesis induction in human lymphocytes by sterols efflux or phytohemagglutinin stimulation : cellular division as the requirement for efficient cholesterol biosynthesis in lymphocytes. 1979 Biochem. Biophys. Res. Commun. pmid:465064
Wiley MH et al. Conversion of mevalonolactone to its open-chain salt by a serum enzyme. 1979 Biochem. Biophys. Res. Commun. pmid:465057
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
van Aller RT et al. The metabolic role of the 24-ethylidenecholesterols. 1968 Biochem. Biophys. Res. Commun. pmid:5665879
Crick DC et al. Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. 1995 Biochem. Biophys. Res. Commun. pmid:7794274
Lee SK et al. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. 2010 Biochem. Biophys. Res. Commun. pmid:20043868
Servouse M et al. Isolation and characterization of yeast mutants blocked in mevalonic acid formation. 1984 Biochem. Biophys. Res. Commun. pmid:6148937
Deneris ES et al. In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction. 1984 Biochem. Biophys. Res. Commun. pmid:6487307
Alaei P et al. Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. 1996 Biochem. Biophys. Res. Commun. pmid:8630058
Hu ZY et al. Neurosteroids: steroidogenesis in primary cultures of rat glial cells after release of aminoglutethimide blockade. 1989 Biochem. Biophys. Res. Commun. pmid:2735928
Sablé-Amplis R and Sicart R Evidence for negative feedback control of cholesterogenesis from mevalonate in liver: absence in the intestine of guinea pigs fed a 0.5% cholesterol diet. 1982 Biochem. Biophys. Res. Commun. pmid:7181883
Cenedella RJ et al. Cholesterylene, a newly recognized tissue lipid, found at high levels in the cornea. 1992 Biochem. Biophys. Res. Commun. pmid:1510688
Gibbons GF Existence of metabolic reservoirs in the later stages of the cholesterol biosynthetic pathway. 1977 Biochem. Biophys. Res. Commun. pmid:861038
Keller RK and Fliesler SJ Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. 1999 Biochem. Biophys. Res. Commun. pmid:10600541
Fuhrman B et al. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. 1997 Biochem. Biophys. Res. Commun. pmid:9168909
Ku EC Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway. 1996 Biochem. Biophys. Res. Commun. pmid:8769113
Aguilera JA et al. Effect of dietary cholesterol on mevalonate metabolism by sterol and nonsterol pathways. 1984 Biochem. Biophys. Res. Commun. pmid:6477574