| MeSH term | MeSH ID | Detail |
|---|---|---|
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
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All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nishimura M et al. | Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. | 1999 | Kidney Int. | pmid:9987076 |
| pmid:9920100 | ||||
| pmid:990276 | ||||
| pmid:9882513 | ||||
| Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
| pmid:9872842 | ||||
| Petras SF et al. | HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. | 1999 | J. Lipid Res. | pmid:9869647 |
| Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
| Melichar B et al. | Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. | 1998 | Clin. Cancer Res. | pmid:9865922 |
| Wellburn AR and Hampp R | Uptake of mevalonate and acetate during plastid development. | 1976 | Biochem. J. | pmid:985424 |
| Shipman CM et al. | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | 1998 | Cancer Res. | pmid:9850051 |
| Disch A and Rohmer M | On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. | 1998 | FEMS Microbiol. Lett. | pmid:9835029 |
| Lamb DC et al. | A sterol biosynthetic pathway in Mycobacterium. | 1998 | FEBS Lett. | pmid:9804188 |
| Schedin S et al. | Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. | 1998 | Biochim. Biophys. Acta | pmid:9795206 |
| Naoumova RP et al. | Cholesterol synthesis is increased in mixed hyperlipidaemia. | 1998 | Biochim. Biophys. Acta | pmid:9795192 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. | 1998 | J. Neurosci. Res. | pmid:9778150 |
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| Coxon FP et al. | Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. | 1998 | Mol. Pharmacol. | pmid:9765505 |
| Hiramatsu M et al. | Enzyme immunoassay of urinary mevalonic acid and its clinical application. | 1998 | Clin. Chem. | pmid:9761249 |
| Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
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| Harrison LE et al. | Phenylacetate inhibits isoprenoid biosynthesis and suppresses growth of human pancreatic carcinoma. | 1998 | Surgery | pmid:9736908 |
| Guijarro C et al. | 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. | 1998 | Circ. Res. | pmid:9734471 |
| Orihara N et al. | Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus. | 1998 | J. Antibiot. | pmid:9727394 |
| Laufs U and Liao JK | Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. | 1998 | J. Biol. Chem. | pmid:9727051 |
| Hinson DD et al. | Hematological abnormalities and cholestatic liver disease in two patients with mevalonate kinase deficiency. | 1998 | Am. J. Med. Genet. | pmid:9714005 |
| Takahashi S et al. | A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9707569 |
| pmid:9703948 | ||||
| Pfohl M et al. | Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions. | 1998 | Eur. J. Clin. Invest. | pmid:9693942 |
| Kitahara M et al. | NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. | 1998 | Jpn. J. Pharmacol. | pmid:9681568 |
| Yan D et al. | Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). | 1998 | J. Biol. Chem. | pmid:9677393 |
| Kashiwagi Y et al. | Mechanical stretch activates a pathway linked to mevalonate metabolism in cultured neonatal rat heart cells. | 1998 | Hypertens. Res. | pmid:9661807 |
| Rieder C et al. | Biosynthesis of the diterpene verrucosan-2beta-ol in the phototrophic eubacterium Chloroflexus aurantiacus. A retrobiosynthetic NMR study. | 1998 | J. Biol. Chem. | pmid:9660767 |
| Disch A et al. | Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. | 1998 | Biochem. J. | pmid:9657979 |
| Nishio E et al. | Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. | 1998 | Eur. J. Pharmacol. | pmid:9650858 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Ramaswamy NK et al. | A novel pathway for the synthesis of solanidine in the isolated chloroplast from greening potatoes. | 1976 | Eur. J. Biochem. | pmid:964241 |
| Adam KP et al. | Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicum. | 1998 | Arch. Biochem. Biophys. | pmid:9633614 |
| Aspbury RA et al. | Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. | 1998 | Biochim. Biophys. Acta | pmid:9630668 |
| Mitropoulos KA and Gibbons GF | Effect of triarimol on cholesterol biosynthesis in rat-liver subcellular. | 1976 | Biochem. Biophys. Res. Commun. | pmid:962959 |
| Melnykovych G et al. | Inhibition of cholesterol biosynthesis in HeLa cells by glucocorticoids. | 1976 | Biochem. Biophys. Res. Commun. | pmid:962938 |
| Crick DC et al. | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. | 1998 | J. Neurochem. | pmid:9603204 |
| Rubins JB et al. | Lovastatin induces apoptosis in malignant mesothelioma cells. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603146 |
| Singh I et al. | Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. | 1998 | FEBS Lett. | pmid:9600263 |
| Orihara N et al. | Studies on the biosynthesis of terpenoidal compounds produced by actinomycetes. 2. Biosynthesis of carquinostatin B via the non-mevalonate pathway in Streptomyces exfoliatus. | 1997 | J. Antibiot. | pmid:9592576 |
| Visioli F et al. | Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells. | 1998 | Alcohol | pmid:9590514 |
| Coutant KD et al. | Fluvastatin enhances receptor-stimulated intracellular Ca2+ release in human keratinocytes. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571146 |
| Kaur M et al. | Receptor-Ck-dependent regulation of genes involved in the cell cycle. | 1998 | Mol. Cell. Biochem. | pmid:9562250 |
| Luckman SP et al. | Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. | 1998 | J. Bone Miner. Res. | pmid:9556058 |
| Gopalaswamy UV and Aiyar AS | Actinomycin D-induced enhancement of ubiquinone biosynthesis in rat. | 1976 | Chem. Biol. Interact. | pmid:954142 |
| Laufs U et al. | Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. | 1998 | Circulation | pmid:9537338 |
| Disch A et al. | Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. | 1998 | Biochem. J. | pmid:9531505 |
| Kalra VK and Blankenhorn DH | Abnormal activation of sterol synthesis in lymphocytes of atherosclerotic-susceptible pigeons and heterozygous familial hypercholesterolemic patients. | 1976 | Biochim. Biophys. Acta | pmid:952994 |
| Rosenthal RS and Rodwell VW | Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon. | 1998 | Protein Sci. | pmid:9514272 |
| Sul D and Kaneshiro ES | Ubiquinone synthesis by Pneumocystis carinii: incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. | 1997 Nov-Dec | J. Eukaryot. Microbiol. | pmid:9508445 |
| Ellsworth JL and Starr JR | Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. | 1998 | Metab. Clin. Exp. | pmid:9500571 |
| Lange BM et al. | A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482845 |
| Natarajan R et al. | Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9480812 |
| Shamburek RD et al. | Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. | 1997 | J. Lipid Res. | pmid:9458266 |
| Kanayama N et al. | Genetic evaluation of physiological functions of thiolase isoenzymes in the n-alkalane-assimilating yeast Candida tropicalis. | 1998 | J. Bacteriol. | pmid:9457876 |
| Kwiterovich PO and Motevalli M | Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445257 |
| Lala A et al. | Apolipoprotein E genotype and cholesterogenesis in polygenic hypercholesterolemia. | 1998 | Metab. Clin. Exp. | pmid:9440485 |
| Hrboticky N et al. | Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin. | 1997 | Biochim. Biophys. Acta | pmid:9434135 |
| Pfohl M et al. | Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect. | 1997 | Atherosclerosis | pmid:9430376 |
| pmid:9430371 | ||||
| Bianchi C et al. | Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. | 1997 | J. Pediatr. | pmid:9427904 |
| Tatsuno I et al. | Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9425279 |
| pmid:942445 | ||||
| Goto D et al. | Upregulation of low density lipoprotein receptor by gemfibrozil, a hypolipidemic agent, in human hepatoma cells through stabilization of mRNA transcripts. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409246 |
| Gadbut AP et al. | Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. | 1997 | EMBO J. | pmid:9405354 |
| Dunzendorfer S et al. | Mevalonate-dependent inhibition of transendothelial migration and chemotaxis of human peripheral blood neutrophils by pravastatin. | 1997 | Circ. Res. | pmid:9400376 |
| Ukai M et al. | Cholesterol synthesis in germfree and conventional rats. | 1976 | J. Nutr. | pmid:939998 |
| Riches FM et al. | Direct association between the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 and plasma mevalonic acid and lathosterol concentrations in man. | 1997 | Atherosclerosis | pmid:9395276 |
| Hinson DD et al. | Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. | 1997 | J. Lipid Res. | pmid:9392419 |
| Pahan K et al. | Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. | 1997 | J. Clin. Invest. | pmid:9389730 |
| pmid:9389491 | ||||
| de Chaves EI et al. | Role of lipoproteins in the delivery of lipids to axons during axonal regeneration. | 1997 | J. Biol. Chem. | pmid:9388216 |
| Forman BM et al. | The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9380679 |
| Marais AD et al. | Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. | 1997 | J. Lipid Res. | pmid:9374129 |
| Hjertman M et al. | Evidence for protein dolichylation. | 1997 | FEBS Lett. | pmid:9373159 |
| Hampton RY and Bhakta H | Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9371780 |
| Feillet C et al. | Cholesterol biosynthesis in normocholesterolemic patients after cholesterol removal by plasmapheresis. | 1997 | J Clin Apher | pmid:9365862 |
| Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
| Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
| pmid:9344354 | ||||
| Hinson DD et al. | Identification of an active site alanine in mevalonate kinase through characterization of a novel mutation in mevalonate kinase deficiency. | 1997 | J. Biol. Chem. | pmid:9334262 |
| Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |
| Potter D and Miziorko HM | Identification of catalytic residues in human mevalonate kinase. | 1997 | J. Biol. Chem. | pmid:9325256 |
| Parmryd I et al. | Chloroplastic prenylated proteins. | 1997 | FEBS Lett. | pmid:9323028 |
| Schwender J et al. | Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. | 1997 | FEBS Lett. | pmid:9305746 |
| Ren Z et al. | Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. | 1997 | Biochem. Pharmacol. | pmid:9296357 |
| Knöss W et al. | Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. | 1997 | Biochem. J. | pmid:9291117 |
| El-Sohemy A and Archer MC | Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. | 1997 | Cancer Res. | pmid:9288773 |
| Meigs TE and Simoni RD | Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. | 1997 | Arch. Biochem. Biophys. | pmid:9281305 |
| Cuthbert JA and Lipsky PE | Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism. | 1997 | Cancer Res. | pmid:9270019 |
| Sakai M et al. | HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein. | 1997 | Atherosclerosis | pmid:9258407 |
| Naoumova RP et al. | Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. | 1997 | J. Lipid Res. | pmid:9254075 |
| Risé P et al. | Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. | 1997 | J. Lipid Res. | pmid:9254057 |
| Bergès T et al. | The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity. | 1997 | J. Bacteriol. | pmid:9244250 |
| Cenedella RJ | Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. | 1997 | Exp. Eye Res. | pmid:9237866 |