Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
pmid:8611028
Gibbons GF Existence of metabolic reservoirs in the later stages of the cholesterol biosynthetic pathway. 1977 Biochem. Biophys. Res. Commun. pmid:861038
Fraser PD et al. Carotenoid biosynthesis in wild type and mutant strains of Mucor circinelloides. 1996 Biochim. Biophys. Acta pmid:8600974
Lewis LS Statins, cholesterol, and mevalonate pathways? 1996 Lancet pmid:8596303
pmid:8592143
Kikuchi A et al. Purification and properties of Rab3A. 1995 Meth. Enzymol. pmid:8583939
Biardi L and Krisans SK Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes. 1996 J. Biol. Chem. pmid:8576183
Parmryd I et al. Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. 1995 Eur. J. Biochem. pmid:8575428
Tachibana A et al. Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. 1996 FEBS Lett. pmid:8566226
Viganõ T et al. Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation. 1995 Eur. J. Pharmacol. pmid:8566171
Weber C et al. Lovastatin induces differentiation of Mono Mac 6 cells. 1995 Cell Biochem. Funct. pmid:8565148
Rea TJ et al. Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells. 1996 Biochim. Biophys. Acta pmid:8555254
Bischoff KM and Rodwell VW 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli. 1996 J. Bacteriol. pmid:8550415
Luján HD et al. Isoprenylation of proteins in the protozoan Giardia lamblia. 1995 Mol. Biochem. Parasitol. pmid:8538683
Massy ZA et al. Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction? 1996 Lancet pmid:8538301
Kocarek TA et al. Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. 1993 Toxicol. Appl. Pharmacol. pmid:8511800
pmid:8507210
Cox AD et al. The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity. 1993 J. Biol. Chem. pmid:8505289
Burt VT et al. The formation of menaquinone-4 (vitamin K) and its oxide in some marine invertebrates. 1977 Biochem. J. pmid:849285
pmid:8491791
Randall SK et al. Protein isoprenylation in suspension-cultured tobacco cells. 1993 Plant Cell pmid:8485402
Seo S et al. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. 1993 Steroids pmid:8484187
pmid:8482726
Doyle JW et al. Effects of growth factors on cell cycle arrest in dolichyl phosphate-depleted cultures. 1993 J. Cell. Physiol. pmid:8468363
Rilling HC et al. Differential prenylation of proteins as a function of mevalonate concentration in CHO cells. 1993 Arch. Biochem. Biophys. pmid:8460935
Schwartz CC et al. Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate. 1993 J. Clin. Invest. pmid:8450070
pmid:8446927
Miura S et al. Inhibition of protein prenylation by patulin. 1993 FEBS Lett. pmid:8436232
pmid:8435109
Li G et al. Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins. 1993 Biochem. J. pmid:8424783
Farrell FX et al. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. 1993 Biochem. J. pmid:8424780
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Swiezewska E et al. Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves. 1993 J. Biol. Chem. pmid:8419349
pmid:8406993
Horbach S et al. Isoprenoid biosynthesis in bacteria: two different pathways? 1993 FEMS Microbiol. Lett. pmid:8405922
Arellano R and Grinstein S Role of isoprenylation in intracellular pH regulation of granulocytes. 1993 FEBS Lett. pmid:8405466
pmid:8403532
Keller RK and Vilsaint F Regulation of isoprenoid metabolism in rat liver: near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis. 1993 Biochim. Biophys. Acta pmid:8399346
Davies JE and Ng LL Simvastatin and intracellular pH regulation by the Na+/H+ antiport of SV40-virus-transformed human MRC5 fibroblasts. 1993 Clin. Sci. pmid:8392920
Parker RA et al. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1993 J. Biol. Chem. pmid:8388388
Hoffmann GF et al. Clinical and biochemical phenotype in 11 patients with mevalonic aciduria. 1993 Pediatrics pmid:8386351
Giroux LM et al. Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages. 1993 Biochim. Biophys. Acta pmid:8380338
Bhat CS and Ramasarma T Rhythmic activity of utilization of mevalonate for biogenesis of cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:836326
Vlahcevic ZR et al. Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat. 1993 Hepatology pmid:8359807
Jones MP et al. Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat. 1993 J. Lipid Res. pmid:8354954
Mancini J et al. Mevalonic aciduria in 3 siblings: a new recognizable metabolic encephalopathy. 1993 May-Jun Pediatr. Neurol. pmid:8352861
Dahl NK et al. Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant. 1993 J. Biol. Chem. pmid:8349588
Li G and Stahl PD Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5). 1993 Arch. Biochem. Biophys. pmid:8346922
pmid:8341325
Komori A et al. Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation. 1993 Cancer Res. pmid:8339247
Kekki M et al. Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man. 1977 J. Lipid Res. pmid:833511
Langdon R et al. Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol. 1977 J. Lipid Res. pmid:833506
Wiley MH et al. The quantitative role of the kidneys in the in vivo metabolism of mevalonate. 1977 J. Biol. Chem. pmid:833143
Kandutsch AA and Chen HW Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition. 1977 J. Biol. Chem. pmid:833134
Preisig-Müller R et al. Heat shock enhances the amount of prenylated Dnaj protein at membranes of glyoxysomes. 1994 Eur. J. Biochem. pmid:8307022
De Cuyper I et al. Determination of changes in serum lathosterol during treatment with simvastatin to evaluate the role of lathosterol as a parameter for whole body cholesterol synthesis. 1993 Clin. Chim. Acta pmid:8306452
pmid:8300194
Schulz S et al. Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes. 1994 Eur. J. Immunol. pmid:8299679
McCaskill D and Croteau R Procedures for the isolation and quantification of the intermediates of the mevalonic acid pathway. 1993 Anal. Biochem. pmid:8297005
Ng LL et al. 3-Hydroxy-3-methyl glutaryl coenzyme A reductase inhibition modulates vasopressin-stimulated Ca2+ responses in rat A10 vascular smooth muscle cells. 1994 Circ. Res. pmid:8293556
Florin-Christensen M et al. Occurrence of specific sterols in Pneumocystis carinii. 1994 Biochem. Biophys. Res. Commun. pmid:8292026
Betteridge DJ et al. Compactin inhibits cholesterol synthesis in lymphocytes and intestinal mucosa from patients with familial hypercholesterolaemia. 1978 Dec 23-30 Lancet pmid:82843
Firmbach-Kraft I and Stick R The role of CaaX-dependent modifications in membrane association of Xenopus nuclear lamin B3 during meiosis and the fate of B3 in transfected mitotic cells. 1993 J. Cell Biol. pmid:8276888
Correll CC and Edwards PA Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. 1994 J. Biol. Chem. pmid:8276863
Roullet JB et al. Mevalonate availability and cardiovascular functions. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8265617
Foster JM et al. Biosynthesis of isoprenoid compounds in Schistosoma mansoni. 1993 Mol. Biochem. Parasitol. pmid:8264731
pmid:8261631
Rohmer M et al. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. 1993 Biochem. J. pmid:8240251
pmid:8236454
pmid:8233712
Derksen A et al. Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. 1976 Biochem. J. pmid:822845
Hoang VQ et al. The regulation of bile acid synthesis in cultured hamster hepatocytes. 1993 Biochem. Soc. Trans. pmid:8224434
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Metz SA et al. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. 1993 Biochem. J. pmid:8216234
pmid:8203881
Grünler J et al. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. 1994 Biochim. Biophys. Acta pmid:8199197
Kawata S et al. Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2). 1994 Br. J. Cancer pmid:8198962
Terkeltaub R et al. Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells. 1994 J. Leukoc. Biol. pmid:8195701
Aberg F et al. Effects of clofibrate, phthalates and probucol on ubiquinone levels. 1994 Chem. Biol. Interact. pmid:8194121
Carlberg M et al. Mevalonate is essential for growth activation of human fibroblasts: evidence for a critical role of protein glycosylation in the prereplicative period. 1994 Exp. Cell Res. pmid:8187830
Hungund BL et al. In vivo incorporation of [2-14C]mevalonic acid into rat brain complex glycolipids: characterization of glycosylsterols in mammalian brain. 1994 Chem. Phys. Lipids pmid:8181105
pmid:8179595
Sinensky M et al. The processing pathway of prelamin A. 1994 J. Cell. Sci. pmid:8175923
pmid:8169651
Wilde J and Eggerer H Substrate and inhibitor specificity of mevalonate kinase determined with substrate analogues. 1994 Eur. J. Biochem. pmid:8168534
Kelleher JK et al. Isotopomer spectral analysis of cholesterol synthesis: applications in human hepatoma cells. 1994 Am. J. Physiol. pmid:8166258
Hampton RY and Rine J Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. 1994 J. Cell Biol. pmid:8163547
Ren Z and Gould MN Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. 1994 Cancer Lett. pmid:8149348
pmid:8147861
Bernini F et al. Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. 1993 Atherosclerosis pmid:8141843
pmid:8133281
pmid:8124722
Mellon SH and Deschepper CF Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. 1993 Brain Res. pmid:8111631
Rahmatullah M and Robishaw JD Direct interaction of the alpha and gamma subunits of the G proteins. Purification and analysis by limited proteolysis. 1994 J. Biol. Chem. pmid:8106401
Capuzzi DM et al. Rapid modulation of lipogenesis by clofibrate in rat and monkey hepatocytes. 1975 Biochim. Biophys. Acta pmid:810176
Giron MD et al. Isopentenoid synthesis in eukaryotic cells. An initiating role for post-translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1993 Arch. Biochem. Biophys. pmid:8097083
Sagami H et al. Novel isoprenoid modified proteins in Halobacteria. 1994 Biochem. Biophys. Res. Commun. pmid:8093082
Müller-Wieland D et al. Melatonin inhibits LDL receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes. 1994 Biochem. Biophys. Res. Commun. pmid:8074686
pmid:8074684
pmid:807214