| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
| Peutz-Jeghers Syndrome | D010580 | 2 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
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There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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We collected disease MeSH terms mapped to the references associated with Mevalonic acid
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All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Itoh D et al. | Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. | 2000 | J. Nat. Prod. | pmid:10978203 |
| Kim SI et al. | Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. | 2000 | J. Am. Soc. Nephrol. | pmid:10616843 |
| Bassa BV et al. | Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. | 1999 | Biochim. Biophys. Acta | pmid:10082972 |
| Agarwal B et al. | Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. | 1999 | Clin. Cancer Res. | pmid:10473109 |
| Gardner RG and Hampton RY | A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. | 1999 | J. Biol. Chem. | pmid:10531376 |
| Cenedella RJ et al. | Lens epithelia contain a high-affinity, membrane steroid hormone-binding protein. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10359327 |
| Girgert R et al. | Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms. | 1999 | Cancer Lett. | pmid:10374838 |
| Niku-Paavola ML et al. | New types of antimicrobial compounds produced by Lactobacillus plantarum. | 1999 | J. Appl. Microbiol. | pmid:10200070 |
| Naoumova RP et al. | Effect of inhibiting HMG-CoA reductase on 7 alpha-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathway. | 1999 | Eur. J. Clin. Invest. | pmid:10354197 |
| Lange BM and Croteau R | Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570138 |
| Lambert M and Bui ND | Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells. | 1999 | Mol. Cell. Biochem. | pmid:10706000 |
| Petras SF et al. | HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. | 1999 | J. Lipid Res. | pmid:9869647 |
| Ravid T et al. | Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells. | 1999 | J. Biol. Chem. | pmid:10506194 |
| Appelkvist EL et al. | Synthesis of mevalonate pathway lipids in fibroblasts from Zellweger and X-linked ALD patients. | 1999 | Pediatr. Res. | pmid:10473053 |
| Reszka AA et al. | Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. | 1999 | J. Biol. Chem. | pmid:10574973 |
| Bifulco M et al. | Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells. | 1999 | Biochimie | pmid:10401660 |
| Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
| Parmryd I and Dallner G | In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups. | 1999 | Arch. Biochem. Biophys. | pmid:10190969 |
| Parmryd I et al. | Protein prenylation in spinach chloroplasts. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10468564 |
| Koch T et al. | Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. | 1999 | Plant Physiol. | pmid:10482670 |
| Ghosh PM et al. | Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. | 1999 | Oncogene | pmid:10435593 |
| Kaul D and Kaur M | Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27). | 1999 | Mol. Cell. Biochem. | pmid:10569199 |
| Sato R et al. | Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. | 1999 | J. Biol. Chem. | pmid:10455139 |
| Ginger ML et al. | Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana. | 1999 | Biochem. J. | pmid:10455027 |
| Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
| Giordano W et al. | Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi. | 1999 | Microbiology (Reading, Engl.) | pmid:10537222 |
| Kim DY et al. | Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. | 1999 | Protein Expr. Purif. | pmid:10600463 |
| Vega GL et al. | Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol. | 1999 | J. Intern. Med. | pmid:10447220 |
| Yoshida T et al. | Plasma levels of mevalonate and 7alpha-hydroxy-4-cholesten-3-one in chronic liver disease. | 1999 | J. Gastroenterol. Hepatol. | pmid:10029296 |
| Shack S et al. | Activation of the cholesterol pathway and Ras maturation in response to stress. | 1999 | Oncogene | pmid:10557091 |
| Elkin RG and Yan Z | Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens. | 1999 | J. Reprod. Fertil. | pmid:10615252 |
| Laufs U et al. | 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). | 1999 | J. Biol. Chem. | pmid:10419514 |
| Rao S et al. | Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393901 |
| Kikuchi A et al. | Evidence for covalent attachment of diphytanylglyceryl phosphate to the cell-surface glycoprotein of Halobacterium halobium. | 1999 | J. Biol. Chem. | pmid:10364251 |
| van beek E et al. | The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates. | 1999 | J. Bone Miner. Res. | pmid:10320520 |
| Bacurau RF et al. | Metabolic response of macrophages to injury promoted by the activated complement system. | 1999 | Cell Biochem. Funct. | pmid:10451538 |
| Mutoh T et al. | Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. | 1999 | FEBS Lett. | pmid:10037153 |
| Nishimura M et al. | Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. | 1999 | Kidney Int. | pmid:9987076 |
| Jomaa H et al. | Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | 1999 | Science | pmid:10477522 |
| Choi JW and Jung SE | Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10087052 |
| Keller RK and Fliesler SJ | Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10600541 |
| Rha SY et al. | Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer. | 1999 | Int. J. Mol. Med. | pmid:10402490 |
| Hinson DD et al. | Hematological abnormalities and cholestatic liver disease in two patients with mevalonate kinase deficiency. | 1998 | Am. J. Med. Genet. | pmid:9714005 |
| Kwiterovich PO and Motevalli M | Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445257 |
| Natarajan R et al. | Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9480812 |
| Coxon FP et al. | Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. | 1998 | Mol. Pharmacol. | pmid:9765505 |
| Aspbury RA et al. | Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. | 1998 | Biochim. Biophys. Acta | pmid:9630668 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Rieder C et al. | Biosynthesis of the diterpene verrucosan-2beta-ol in the phototrophic eubacterium Chloroflexus aurantiacus. A retrobiosynthetic NMR study. | 1998 | J. Biol. Chem. | pmid:9660767 |
| Lala A et al. | Apolipoprotein E genotype and cholesterogenesis in polygenic hypercholesterolemia. | 1998 | Metab. Clin. Exp. | pmid:9440485 |
| Kitahara M et al. | NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. | 1998 | Jpn. J. Pharmacol. | pmid:9681568 |
| Naoumova RP et al. | Cholesterol synthesis is increased in mixed hyperlipidaemia. | 1998 | Biochim. Biophys. Acta | pmid:9795192 |
| Disch A et al. | Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. | 1998 | Biochem. J. | pmid:9657979 |
| Shipman CM et al. | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | 1998 | Cancer Res. | pmid:9850051 |
| Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
| Coutant KD et al. | Fluvastatin enhances receptor-stimulated intracellular Ca2+ release in human keratinocytes. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571146 |
| Nishio E et al. | Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. | 1998 | Eur. J. Pharmacol. | pmid:9650858 |
| Adam KP et al. | Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicum. | 1998 | Arch. Biochem. Biophys. | pmid:9633614 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. | 1998 | J. Neurosci. Res. | pmid:9778150 |
| Schedin S et al. | Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. | 1998 | Biochim. Biophys. Acta | pmid:9795206 |
| Lamb DC et al. | A sterol biosynthetic pathway in Mycobacterium. | 1998 | FEBS Lett. | pmid:9804188 |
| Singh I et al. | Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. | 1998 | FEBS Lett. | pmid:9600263 |
| Visioli F et al. | Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells. | 1998 | Alcohol | pmid:9590514 |
| Kaur M et al. | Receptor-Ck-dependent regulation of genes involved in the cell cycle. | 1998 | Mol. Cell. Biochem. | pmid:9562250 |
| Pfohl M et al. | Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions. | 1998 | Eur. J. Clin. Invest. | pmid:9693942 |
| Ellsworth JL and Starr JR | Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. | 1998 | Metab. Clin. Exp. | pmid:9500571 |
| Lange BM et al. | A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482845 |
| Hiramatsu M et al. | Enzyme immunoassay of urinary mevalonic acid and its clinical application. | 1998 | Clin. Chem. | pmid:9761249 |
| Orihara N et al. | Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus. | 1998 | J. Antibiot. | pmid:9727394 |
| Yan D et al. | Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). | 1998 | J. Biol. Chem. | pmid:9677393 |
| Kashiwagi Y et al. | Mechanical stretch activates a pathway linked to mevalonate metabolism in cultured neonatal rat heart cells. | 1998 | Hypertens. Res. | pmid:9661807 |
| Luckman SP et al. | Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. | 1998 | J. Bone Miner. Res. | pmid:9556058 |
| Laufs U et al. | Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. | 1998 | Circulation | pmid:9537338 |
| Disch A et al. | Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. | 1998 | Biochem. J. | pmid:9531505 |
| Rosenthal RS and Rodwell VW | Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon. | 1998 | Protein Sci. | pmid:9514272 |
| Kanayama N et al. | Genetic evaluation of physiological functions of thiolase isoenzymes in the n-alkalane-assimilating yeast Candida tropicalis. | 1998 | J. Bacteriol. | pmid:9457876 |
| Harrison LE et al. | Phenylacetate inhibits isoprenoid biosynthesis and suppresses growth of human pancreatic carcinoma. | 1998 | Surgery | pmid:9736908 |
| Takahashi S et al. | A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9707569 |
| Rubins JB et al. | Lovastatin induces apoptosis in malignant mesothelioma cells. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603146 |
| Crick DC et al. | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. | 1998 | J. Neurochem. | pmid:9603204 |
| Disch A and Rohmer M | On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. | 1998 | FEMS Microbiol. Lett. | pmid:9835029 |
| Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
| Melichar B et al. | Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. | 1998 | Clin. Cancer Res. | pmid:9865922 |
| Laufs U and Liao JK | Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. | 1998 | J. Biol. Chem. | pmid:9727051 |
| Guijarro C et al. | 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. | 1998 | Circ. Res. | pmid:9734471 |
| Vion-Dury J et al. | Atlas of brain proton magnetic resonance spectra. Part II: Inherited metabolic encephalopathies. | 1998 | J Neuroradiol | pmid:10048272 |
| Sul D and Kaneshiro ES | Ubiquinone synthesis by Pneumocystis carinii: incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. | 1997 Nov-Dec | J. Eukaryot. Microbiol. | pmid:9508445 |
| Risé P et al. | Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. | 1997 | J. Lipid Res. | pmid:9254057 |
| Naoumova RP et al. | Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. | 1997 | J. Lipid Res. | pmid:9254075 |
| Bianchi C et al. | Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. | 1997 | J. Pediatr. | pmid:9427904 |
| Pfohl M et al. | Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect. | 1997 | Atherosclerosis | pmid:9430376 |
| Riches FM et al. | Direct association between the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 and plasma mevalonic acid and lathosterol concentrations in man. | 1997 | Atherosclerosis | pmid:9395276 |
| Tatsuno I et al. | Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9425279 |
| Cuthbert JA and Lipsky PE | Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism. | 1997 | Cancer Res. | pmid:9270019 |
| El-Sohemy A and Archer MC | Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. | 1997 | Cancer Res. | pmid:9288773 |
| Bergès T et al. | The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity. | 1997 | J. Bacteriol. | pmid:9244250 |
| Raiteri M et al. | Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190847 |
| Anouja F et al. | The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins. | 1997 | J. Virol. | pmid:9151861 |
| Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |
| Paton VG et al. | Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. | 1997 | J. Biol. Chem. | pmid:9228075 |