Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
Alvarez De Sotomayor M et al. Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. 2000 Br. J. Pharmacol. pmid:11082126
Gregory DH et al. Mechanism of secretion of biliary lipids. I. Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol. 1975 J. Clin. Invest. pmid:1109174
Palinski W Immunomodulation: a new role for statins? 2000 Nat. Med. pmid:11100105
Jones JP et al. Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. 1975 J. Neurochem. pmid:1110355
pmid:11108295
pmid:11111075
Hahn FM et al. 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. 2001 J. Bacteriol. pmid:11114895
Daugherty M et al. Archaeal shikimate kinase, a new member of the GHMP-kinase family. 2001 J. Bacteriol. pmid:11114929
Campos N et al. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. 2001 Biochem. J. pmid:11115399
Chen H et al. Fluvastatin upregulates inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells. 2000 Hypertension pmid:11116101
Asada Y et al. Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway. 2000 Phytochemistry pmid:11117880
Fogelman AM et al. Metabolism of mevalonate in rats and man not leading to sterols. 1975 J. Biol. Chem. pmid:1112830
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Ginger ML et al. The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana. 2001 J. Biol. Chem. pmid:11148203
Laffitte BA et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11149950
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Luo JD et al. Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes. 2001 Br. J. Pharmacol. pmid:11156573
Kaneda K et al. An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11158573
Dunford JE et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. 2001 J. Pharmacol. Exp. Ther. pmid:11160603
Reszka AA et al. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. 2001 Mol. Pharmacol. pmid:11160853
Alvarez de Sotomayor M and Andriantsitohaina R Simvastatin and Ca(2+) signaling in endothelial cells: involvement of rho protein. 2001 Biochem. Biophys. Res. Commun. pmid:11162544
Kritchevsky D et al. Experimental atherosclerosis in rabbits fed cholesterol-free diets. 4. Investigation into the source of cholesteremia. 1975 Exp. Mol. Pathol. pmid:1116563
Fogelman AM et al. Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. 1975 J. Biol. Chem. pmid:1116997
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Eisenreich W et al. Deoxyxylulose phosphate pathway to terpenoids. 2001 Trends Plant Sci. pmid:11173292
García-Román N et al. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. 2001 Mol. Cell. Neurosci. pmid:11178870
Chiang JY et al. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). 2001 Gene pmid:11179691
Gibbons GF and Mitropoulos KA Effect of trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride and carbon monoxide on hepatic cholesterol biosynthesis from 4,4,-dimethyl sterols in vitro. 1975 Biochim. Biophys. Acta pmid:1120146
Dimitroulakos J et al. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. 2001 Clin. Cancer Res. pmid:11205904
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pmid:11222952
Kovanen PT et al. Regulation of cholesterol synthesis and storage in fat cells. 1975 J. Lipid Res. pmid:1127358
Altincicek B et al. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. 2001 J. Bacteriol. pmid:11274098
pmid:11275002
pmid:11281132
Archelas A and Furstoss R Synthetic applications of epoxide hydrolases. 2001 Curr Opin Chem Biol pmid:11282336
Jenkins DJ et al. Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. 2001 Metab. Clin. Exp. pmid:11288049
Schwender J et al. Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. 2001 Planta pmid:11289606
Zhang Z et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. 2001 J. Lipid Res. pmid:11290837
Blader IJ et al. Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. 2001 J. Biol. Chem. pmid:11294868
Sapkota GP et al. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. 2001 J. Biol. Chem. pmid:11297520
Sharkey TD et al. Isoprene increases thermotolerance of fosmidomycin-fed leaves. 2001 Plant Physiol. pmid:11299379
pmid:11305090
Jagdev SP et al. The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. 2001 Br. J. Cancer pmid:11308265
Houten SM et al. Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. 2001 Eur. J. Hum. Genet. pmid:11313768
Skaletz-Rorowski A et al. Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. 2001 Eur. J. Cell Biol. pmid:11322384
Takemoto M et al. NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. 2001 Br. J. Pharmacol. pmid:11325797
pmid:11336263
Martínez-González J et al. 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11348878
O'Neill FH et al. Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11348882
Chang JJ et al. The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. 2001 Pharmacology pmid:11359999
pmid:11371670
Stalker TJ et al. A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. 2001 Br. J. Pharmacol. pmid:11375257
Raicht RF et al. Sterol balance studies in the rat. Effects of dietary cholesterol and beta-sitosterol on sterol balance and rate-limiting enzymes of sterol metabolism. 1975 Biochim. Biophys. Acta pmid:1137717
pmid:11379812
Scoppola A et al. Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. 2001 Atherosclerosis pmid:11395032
pmid:11397393
Yasunari K et al. HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11397700
Wong B et al. Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. 2001 J. Leukoc. Biol. pmid:11404382
Shukolyukov SA and Saakov VS American cockroach (Periplaneta americana) synthesizes carotenoids from the precursor. 2001 Biochemistry Mosc. pmid:11405890
pmid:11408165
Altincicek B et al. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. 2001 FEBS Lett. pmid:11418107
McCarty MF Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. 2001 Med. Hypotheses pmid:11425277
pmid:11427897
Fujita T et al. Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. 2001 Jpn. J. Pharmacol. pmid:11430477
Karunagoda RP et al. Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. 2001 Biosci. Biotechnol. Biochem. pmid:11440120
Frenkel J et al. Increased urinary leukotriene E(4) during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome. 2001 Arch. Dis. Child. pmid:11466192
Zeidler J and Lichtenthaler HK Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. 2001 Planta pmid:11469599
Martínez-Botas J et al. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. 2001 Biochim. Biophys. Acta pmid:11470239
Smith AG and Goad LJ Sterol biosynthesis in the echinoderm Asterias rubens. 1975 Biochem. J. pmid:1147897
Blomquist GJ et al. Biosynthesis of 3-methylpentacosane in the cockroach Periplaneta americana. 1975 Biochem. Biophys. Res. Commun. pmid:1147933
Swell L et al. Rapid feedback inhibition of endogenous cholic and chenodeoxycholic acid synthesis by exogenous chenodeoxycholic acid in man. 1975 Biochem. Biophys. Res. Commun. pmid:1147960
pmid:11486909
pmid:11486910
Eberlein M et al. Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). 2001 Br. J. Pharmacol. pmid:11487529
Diomede L et al. In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11498461
pmid:11500171
Hamano Y et al. Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. 2001 Biosci. Biotechnol. Biochem. pmid:11515548
pmid:11517351
pmid:11518463
Haas D et al. Inherited disorders of cholesterol biosynthesis. 2001 Neuropediatrics pmid:11521206
Lange BM et al. Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. 2001 Plant Physiol. pmid:11553758
Ranganathan S and Ramasarma T The regulation of the biosynthesis of ubiquinone in the rat. 1975 Biochem. J. pmid:1156398
Dairi T et al. Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. 2001 J. Bacteriol. pmid:11567009
Rao AV and Ramakrishnan S Indirect assessment of hydroxymethylglutaryl-CoA reductase (NADPH) activity in liver tissue. 1975 Clin. Chem. pmid:1157326
Rohdich F et al. The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. 2001 Curr Opin Chem Biol pmid:11578926
Degraeve F et al. Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. 2001 J. Biol. Chem. pmid:11591701
Nwokoro NA et al. Genetic disorders of cholesterol biosynthesis in mice and humans. 2001 Sep-Oct Mol. Genet. Metab. pmid:11592808
Suri S et al. Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. 2001 Bone pmid:11595616
Bede JC et al. Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. 2001 Plant Physiol. pmid:11598232
Gan X et al. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. 2001 J. Biol. Chem. pmid:11641412
Granzow C et al. Synthesis of lipids, cholesterol precursors and cholesterol in glycogen-free and glycogen-synthesizing sublines of the Ehrlich ascites tumor. 1975 Biochem. Biophys. Res. Commun. pmid:1164435
Jones JP et al. The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats. 1975 J. Neurochem. pmid:1167373
Hjertman M et al. Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. 2001 Biochem. Biophys. Res. Commun. pmid:11676505
Chamberlain LH Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. 2001 FEBS Lett. pmid:11696371
Rasmussen LM et al. Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. 2001 Biochem. J. pmid:11716764
pmid:11728917
pmid:11730868
Fellermeier M et al. Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. 2001 Eur. J. Biochem. pmid:11733027
Ichiki T et al. Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11742861