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2008 |
Proc. Natl. Acad. Sci. U.S.A. |
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Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. |
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7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. |
2008 |
J. Atheroscler. Thromb. |
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Combination therapy in cholesterol reduction: focus on ezetimibe and statins. |
2008 |
Vasc Health Risk Manag |
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Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. |
2008 |
Kidney Int. |
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Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. |
2008 |
BMC Syst Biol |
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Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. |
2008 |
Lipids |
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Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. |
2008 |
J. Biochem. Biophys. Methods |
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Modulation of osteoclastogenesis by fatty acids. |
2008 |
Endocrinology |
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Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. |
2008 |
Plant Cell Physiol. |
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FEBS J. |
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Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. |
2008 |
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Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. |
2008 |
J. Bioenerg. Biomembr. |
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Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. |
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Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. |
2008 |
Food Nutr Res |
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[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
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Atorvastatin and cardiovascular risk in the elderly--patient considerations. |
2008 |
Clin Interv Aging |
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Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. |
2008 |
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Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. |
2008 |
Biosci. Biotechnol. Biochem. |
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The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. |
2008 |
Endocr. Relat. Cancer |
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Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. |
2008 |
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Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. |
2008 |
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Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. |
2008 |
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Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. |
2008 |
Nitric Oxide |
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Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. |
2008 |
Kidney Int. |
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Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. |
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Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
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Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. |
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[Effect of pitavastatin on macrophage cholesterol metabolism]. |
2008 |
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Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. |
2008 |
Leuk. Lymphoma |
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The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. |
2008 |
BMC Cancer |
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Neuroprotective effects of garlic a review. |
2008 |
Libyan J Med |
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Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
2008 |
Anal Chem Insights |
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Mol. Cell. Biochem. |
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Mol. Pharmacol. |
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Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. |
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Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. |
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Infect. Immun. |
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High-content assay to study protein prenylation. |
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J Biomol Screen |
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Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. |
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Biochim. Biophys. Acta |
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Microb. Cell Fact. |
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Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
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Cardiology |
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Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. |
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Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. |
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Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. |
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N. Engl. J. Med. |
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Coenzyme Q10 in phenylketonuria and mevalonic aciduria. |
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Mitochondrion |
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PLoS Comput. Biol. |
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Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. |
2007 |
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Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. |
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Chem. Pharm. Bull. |
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Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. |
2007 |
Biochem. Pharmacol. |
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Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. |
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Plant Biotechnol. J. |
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Are pleiotropic effects of statins real? |
2007 |
Vasc Health Risk Manag |
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Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. |
2007 |
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Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. |
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Mevalonic aciduria cured by bone marrow transplantation. |
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N. Engl. J. Med. |
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Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. |
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Blood |
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Activation of the integrated stress response regulates lovastatin-induced apoptosis. |
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Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. |
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Cancer Res. |
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Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. |
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Cytokine |
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Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. |
2007 |
Lipids Health Dis |
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Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). |
2007 |
Phytochemistry |
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Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
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J. Pharmacol. Exp. Ther. |
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Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. |
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Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. |
2007 |
Mol. Cancer |
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A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. |
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The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia. |
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Heart Int |
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Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. |
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Arterioscler. Thromb. Vasc. Biol. |
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Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
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ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. |
2007 |
Appl. Environ. Microbiol. |
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Mevalonate pathway: a review of clinical and therapeutical implications. |
2007 |
Clin. Biochem. |
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Statins induce differentiation and cell death in neurons and astroglia. |
2007 |
Glia |
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Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. |
2007 |
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Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. |
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Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. |
2007 |
Protein Sci. |
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Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. |
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Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. |
2007 |
Clin. Immunol. |
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