Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Gerber R et al. Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. 2004 Anal. Biochem. pmid:15136164
Schwartz CC et al. Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. 2004 J. Lipid Res. pmid:15145983
Hedl M and Rodwell VW Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. 2004 Protein Sci. pmid:15152097
Duncan RE et al. Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. 2004 J. Biol. Chem. pmid:15155733
Rasouli M et al. Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. 2004 Biochim. Biophys. Acta pmid:15158760
pmid:15169608
pmid:15171940
Dickschat JS et al. Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. 2004 Chembiochem pmid:15174160
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Stojanov S et al. Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. 2004 Arthritis Rheum. pmid:15188372
pmid:15197467
Ando H et al. Effects of pravastatin on the expression of ATP-binding cassette transporter A1. 2004 J. Pharmacol. Exp. Ther. pmid:15210833
Le Jossic-Corcos C et al. Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. 2004 Biochim. Biophys. Acta pmid:15238219
pmid:1524429
Siddals KW et al. Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. 2004 J. Biol. Chem. pmid:15247258
Harada-Shiba M et al. Siblings with normal LDL receptor activity and severe hypercholesterolemia. 1992 Arterioscler. Thromb. pmid:1525122
Bradfute DL et al. Squalene synthase-deficient mutant of Chinese hamster ovary cells. 1992 J. Biol. Chem. pmid:1526971
pmid:15279616
Fortin DL et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. 2004 J. Neurosci. pmid:15282274
Sutherlin A and Rodwell VW Multienzyme mevalonate pathway bioreactor. 2004 Biotechnol. Bioeng. pmid:15286992
Werner M et al. Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells. 2004 Br. J. Pharmacol. pmid:15289292
Schulz S et al. Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis. 1992 Cancer Res. pmid:1531325
Vaughan CJ and Gotto AM Update on statins: 2003. 2004 Circulation pmid:15313959
del Real G et al. Statins inhibit HIV-1 infection by down-regulating Rho activity. 2004 J. Exp. Med. pmid:15314078
Ikeuchi H et al. Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. 2004 Nephron Exp. Nephrol. pmid:15331935
pmid:15332174
Ferrara DE et al. Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. 2004 J. Thromb. Haemost. pmid:15333031
pmid:15352124
pmid:15355237
Zanotti I et al. Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. 2004 Biochem. Biophys. Res. Commun. pmid:15358158
Bi X et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. 2004 J. Biol. Chem. pmid:15364922
pmid:15370280
Sauter GH et al. Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. 2004 Digestion pmid:15375335
Dahl NK et al. Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. 1992 J. Biol. Chem. pmid:1537866
Umlauf D et al. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). 2004 Phytochemistry pmid:15381410
Duncan RE et al. Delivery of mevalonate to murine extrahepatic tissues via mini-osmotic pumps. 2004 Sep-Oct J Pharmacol Toxicol Methods pmid:15385088
Kizu A et al. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. 2004 J. Cell. Biochem. pmid:15389884
Seker T et al. Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. 2005 Appl. Microbiol. Biotechnol. pmid:15448940
Neville-Webbe HL et al. Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. 2005 Int. J. Cancer pmid:15455384
Sinensky M and Lutz RJ The prenylation of proteins. 1992 Bioessays pmid:1546978
Bhavnani BR and Woolever CA Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus. 1978 Endocrinology pmid:155006
Fan P et al. Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. 2004 Circ. J. pmid:15502389
pmid:15503662
Anant JS and Fung BK In vivo farnesylation of rat rhodopsin kinase. 1992 Biochem. Biophys. Res. Commun. pmid:1550556
Giannakouros T et al. Protein prenylation in Schizosaccharomyces pombe. 1992 FEBS Lett. pmid:1551414
Kasim SE et al. Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat. 1992 J. Lipid Res. pmid:1552226
Bell FP et al. L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits. 1992 J. Nutr. pmid:1552371
Friesen JA and Rodwell VW The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. 2004 Genome Biol. pmid:15535874
pmid:15542379
pmid:15544330
Raschke M et al. A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. 2004 Anal. Biochem. pmid:15556562
Panda T and Devi VA Regulation and degradation of HMGCo-A reductase. 2004 Appl. Microbiol. Biotechnol. pmid:15558272
Sawamura M et al. Liver mevalonate 5-pyrophosphate decarboxylase is responsible for reduced serum cholesterol in stroke-prone spontaneously hypertensive rat. 1992 J. Biol. Chem. pmid:1556116
Mokashi V et al. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. 2005 Arch. Biochem. Biophys. pmid:15581604
Sakamoto K et al. Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15591221
pmid:15591471
Fenton RG et al. Regulation of intracellular actin polymerization by prenylated cellular proteins. 1992 J. Cell Biol. pmid:1560030
Tabata K and Hashimoto S Production of mevalonate by a metabolically-engineered Escherichia coli. 2004 Biotechnol. Lett. pmid:15604784
pmid:15605175
Hewitt RE et al. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. 2005 Clin. Exp. Immunol. pmid:15606619
Andreassi JL et al. Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. 2004 Biochemistry pmid:15610040
Duncan RE et al. Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. 2005 Mol Nutr Food Res pmid:15617098
pmid:15618295
Wu B et al. Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15618546
Inomata M et al. Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. 2004 Biosci. Biotechnol. Biochem. pmid:15618629
Mahmud T et al. A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. 2005 Chembiochem pmid:15619721
Dudareva N et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15630092
Cordle A and Landreth G 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. 2005 J. Neurosci. pmid:15647473
Pedrini S et al. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. 2005 PLoS Med. pmid:15647781
Havel CM and Watson JA Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination. 1992 Arch. Biochem. Biophys. pmid:1567218
pmid:15680987
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306
Lutz RJ et al. Feedback inhibition of polyisoprenyl pyrophosphate synthesis from mevalonate in vitro. Implications for protein prenylation. 1992 J. Biol. Chem. pmid:1569056
Nawarskas JJ HMG-CoA reductase inhibitors and coenzyme Q10. 2005 Mar-Apr Cardiol Rev pmid:15705257
Madonna R et al. Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. 2005 J. Biol. Chem. pmid:15705589
Wei H et al. Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. 2005 FEBS Lett. pmid:15710425
Baker SK Molecular clues into the pathogenesis of statin-mediated muscle toxicity. 2005 Muscle Nerve pmid:15712281
Kawasaki T et al. Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. 2004 J. Antibiot. pmid:15712669
pmid:15733940
McCarey DW et al. Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? 2005 Arthritis Res. Ther. pmid:15743490
Han KH et al. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. 2005 Circulation pmid:15781755
Mantha AJ et al. Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. 2005 Clin. Cancer Res. pmid:15788691
Okada K and Hase T Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. 2005 J. Biol. Chem. pmid:15792953
Akiyama K et al. Antitumor effect of geranylamine derivatives on human hepatoma. 2005 Jan-Feb In Vivo pmid:15796170
Hampel D et al. Induction of de novo volatile terpene biosynthesis via cytosolic and plastidial pathways by methyl jasmonate in foliage of Vitis vinifera L. 2005 J. Agric. Food Chem. pmid:15796607
Argmann CA et al. Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. 2005 J. Biol. Chem. pmid:15817453
pmid:15822054
pmid:15850779
pmid:15857290
pmid:15857307
Bellosta S et al. Statins effect on smooth muscle cell proliferation. 2004 Semin Vasc Med pmid:15861311
pmid:1586169
Wang C et al. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. 2005 Mol. Cell pmid:15893726
Sacher J et al. Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. 2005 J. Pharmacol. Exp. Ther. pmid:15914674
pmid:15920353
pmid:15936988
pmid:15960521
Newman CM et al. Post-translational processing of Schizosaccharomyces pombe YPT proteins. 1992 J. Biol. Chem. pmid:1597466
Yazawa H et al. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. 2005 J. Periodontol. pmid:15974856
pmid:15981409