| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
| Peutz-Jeghers Syndrome | D010580 | 2 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kuroda M et al. | Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. | 2007 | J. Antimicrob. Chemother. | pmid:17242033 |
| Hao M et al. | Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. | 2007 | Diabetes | pmid:17575085 |
| Parsons RB et al. | A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. | 2007 | J. Neurochem. | pmid:17472704 |
| Araki S et al. | Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. | 2007 | Free Radic. Res. | pmid:17729120 |
| Maurer-Stroh S et al. | Towards complete sets of farnesylated and geranylgeranylated proteins. | 2007 | PLoS Comput. Biol. | pmid:17411337 |
| Llorente A et al. | Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. | 2007 | Eur. J. Cell Biol. | pmid:17601634 |
| Jahangir T and Sultana S | Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. | 2007 | Evid Based Complement Alternat Med | pmid:18227911 |
| Li M et al. | Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17545489 |
| Merrell MA et al. | Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. | 2007 | Eur. J. Pharmacol. | pmid:17640631 |
| Wong WW et al. | Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. | 2007 | Mol. Cancer Ther. | pmid:17575117 |
| Kutrzeba L et al. | Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. | 2007 | Phytochemistry | pmid:17574635 |
| Hunter WN | The non-mevalonate pathway of isoprenoid precursor biosynthesis. | 2007 | J. Biol. Chem. | pmid:17442674 |
| Takeda I et al. | Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. | 2007 | Cancer Sci. | pmid:17428261 |
| Roelofs AJ et al. | Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17412884 |
| Henriksson LM et al. | Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. | 2007 | J. Biol. Chem. | pmid:17491006 |
| Mönkkönen H et al. | Zoledronic acid-induced IPP/ApppI production in vivo. | 2007 | Life Sci. | pmid:17850825 |
| Towler MJ and Weathers PJ | Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. | 2007 | Plant Cell Rep. | pmid:17710406 |
| Riganti C et al. | Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322126 |
| Habib A et al. | Modulation of COX-2 expression by statins in human monocytic cells. | 2007 | FASEB J. | pmid:17317725 |
| Lee MH et al. | Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. | 2007 | Stem Cells | pmid:17464088 |
| Nakajima H et al. | Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. | 2007 | Cancer Lett. | pmid:17316980 |
| Kinjoh T et al. | Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. | 2007 | Insect Biochem. Mol. Biol. | pmid:17628279 |
| Saha RN and Pahan K | Regulation of inducible nitric oxide synthase gene in glial cells. | 2006 May-Jun | Antioxid. Redox Signal. | pmid:16771683 |
| Seong K et al. | Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. | 2006 | Fungal Genet. Biol. | pmid:16377218 |
| Haratake A et al. | Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | 2006 | Skin Pharmacol Physiol | pmid:16778459 |
| Dincer M et al. | Statins may decrease skeletal-related events in breast cancer patients with bone metastases. | 2006 | Med. Hypotheses | pmid:16844315 |
| Kwintkiewicz J et al. | Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. | 2006 | Fertil. Steril. | pmid:16963032 |
| Pozo M et al. | Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. | 2006 | Eur. J. Pharmacol. | pmid:16973154 |
| Piotrowski PC et al. | Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. | 2006 | Biol. Reprod. | pmid:16571871 |
| Sakoda K et al. | Simvastatin decreases IL-6 and IL-8 production in epithelial cells. | 2006 | J. Dent. Res. | pmid:16723648 |
| Kanellis J et al. | Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | 2006 | Immunol. Cell Biol. | pmid:16405649 |
| Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
| Hampel D et al. | Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. | 2006 | J. Agric. Food Chem. | pmid:16478276 |
| Ro DK et al. | Production of the antimalarial drug precursor artemisinic acid in engineered yeast. | 2006 | Nature | pmid:16612385 |
| Sjögren B et al. | Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | 2006 | Eur. J. Pharmacol. | pmid:17064686 |
| Ohm TG and Meske V | Cholesterol, statins and tau. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866917 |
| Crisby M | The role of pleiotropic effects of statins in dementia. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866920 |
| Chana RS and Brunskill NJ | Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | 2006 | Am. J. Nephrol. | pmid:16508249 |
| Macreadie IG et al. | Growth inhibition of Candida species and Aspergillus fumigatus by statins. | 2006 | FEMS Microbiol. Lett. | pmid:16907733 |
| Kosztáczky B et al. | Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. | 2006 | Neuropeptides | pmid:17049599 |
| Ridsdale A et al. | Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. | 2006 | Mol. Biol. Cell | pmid:16452637 |
| Gómez-Hernández A et al. | Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16424787 |
| Kinderlerer AR et al. | Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16859540 |
| Kotti TJ et al. | Brain cholesterol turnover required for geranylgeraniol production and learning in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16505352 |
| Sato M et al. | Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. | 2006 | J Oleo Sci | pmid:17693695 |
| Kuzina V et al. | Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. | 2006 | Arch. Microbiol. | pmid:17009023 |
| Li JQ et al. | Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. | 2006 | Clin. Chim. Acta | pmid:16507303 |
| Parsons RB et al. | Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. | 2006 | Biochem. J. | pmid:16803455 |
| Brinkkoetter PT et al. | Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. | 2006 | Clin. Exp. Immunol. | pmid:17100774 |
| Mandey SH et al. | A role for geranylgeranylation in interleukin-1beta secretion. | 2006 | Arthritis Rheum. | pmid:17075828 |
| Ural AU et al. | In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. | 2006 | Breast Cancer Res. | pmid:16925824 |
| van Hellemond JJ and Tielens AG | Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. | 2006 | FEBS Lett. | pmid:16920110 |
| Saini GS et al. | Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | 2006 | J. Lipid Res. | pmid:16861623 |
| Yi P et al. | The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | 2006 | Science | pmid:16857902 |
| Dimitroulakos J et al. | Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. | 2006 | Clin. Cancer Res. | pmid:16857822 |
| Xu H et al. | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16774905 |
| Kawasaki T et al. | Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. | 2006 | J. Bacteriol. | pmid:16452404 |
| Haas D and Hoffmann GF | Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. | 2006 | Orphanet J Rare Dis | pmid:16722536 |
| Solito E et al. | Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. | 2006 | FASEB J. | pmid:16720734 |
| Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
| Silvander M et al. | A new water-based topical carrier with polar skin-lipids. | 2006 | Lipids Health Dis | pmid:16672068 |
| Coward WR et al. | Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. | 2006 | J. Immunol. | pmid:16621994 |
| Neville-Webbe HL et al. | Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. | 2006 | Tumour Biol. | pmid:16582586 |
| Rattan R et al. | Rho/ROCK pathway as a target of tumor therapy. | 2006 | J. Neurosci. Res. | pmid:16385577 |
| Wang J et al. | Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. | 2006 | Biol. Pharm. Bull. | pmid:16595893 |
| Benetka W et al. | Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. | 2006 | BMC Biochem. | pmid:16507103 |
| Xu L et al. | [Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. | 2006 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:16503530 |
| Riganti C et al. | Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. | 2006 | Int. J. Cancer | pmid:16450390 |
| Ramasubbu K and Mann DL | The emerging role of statins in the treatment of heart failure. | 2006 | J. Am. Coll. Cardiol. | pmid:16412858 |
| Christensen M et al. | Simvastatin protection against acute immune-mediated glomerulonephritis in mice. | 2006 | Kidney Int. | pmid:16407885 |
| González-Fernández L et al. | Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. | 2006 | FEBS J. | pmid:16367743 |
| Zahiri HS et al. | Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. | 2006 | Metab. Eng. | pmid:16815062 |
| Pappu AS et al. | Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. | 2006 | J. Lipid Res. | pmid:16983147 |
| Yoon SH et al. | Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. | 2006 | Biotechnol. Bioeng. | pmid:16547999 |
| Nagashima T et al. | Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. | 2006 | Arthritis Rheum. | pmid:16447234 |
| Yokota K et al. | Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 2006 | J. Rheumatol. | pmid:16511915 |
| Grochowski LL et al. | Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | 2006 | J. Bacteriol. | pmid:16621811 |
| Alegret M and Silvestre JS | Pleiotropic effects of statins and related pharmacological experimental approaches. | 2006 | Methods Find Exp Clin Pharmacol | pmid:17200729 |
| Muñoz-GarcÃa B et al. | Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. | 2006 | Stroke | pmid:16809572 |
| Shang F et al. | Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094942 |
| Issat T et al. | Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. | 2006 | Oncol. Rep. | pmid:17089049 |
| Kuwana M | Potential benefit of statins for vascular disease in systemic sclerosis. | 2006 | Curr Opin Rheumatol | pmid:17053504 |
| Thompson K et al. | Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. | 2006 | Blood | pmid:16179378 |
| van Beek E et al. | Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. | 2006 | Bone | pmid:16165408 |
| Hamadmad SN et al. | Erythropoietin receptor signal transduction requires protein geranylgeranylation. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16203826 |
| Qiu Y and Li D | Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. | 2006 | Org. Lett. | pmid:16524256 |
| Qiu Y and Li D | Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. | 2006 | Biochim. Biophys. Acta | pmid:16626865 |
| Beckman JA and Creager MA | The nonlipid effects of statins on endothelial function. | 2006 | Trends Cardiovasc. Med. | pmid:16781949 |
| Caruso MG and Notarnicola M | Biochemical changes of mevalonate pathway in human colorectal cancer. | 2005 Sep-Oct | Anticancer Res. | pmid:16101154 |
| Nawarskas JJ | HMG-CoA reductase inhibitors and coenzyme Q10. | 2005 Mar-Apr | Cardiol Rev | pmid:15705257 |
| Akiyama K et al. | Antitumor effect of geranylamine derivatives on human hepatoma. | 2005 Jan-Feb | In Vivo | pmid:15796170 |
| Baker SK and Tarnopolsky MA | Statin-associated neuromyotoxicity. | 2005 | Drugs Today | pmid:16034491 |
| Seker T et al. | Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. | 2005 | Appl. Microbiol. Biotechnol. | pmid:15448940 |
| Donovan JM et al. | Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. | 2005 | Dig. Dis. Sci. | pmid:16047465 |
| Hargreaves IP et al. | The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. | 2005 | Drug Saf | pmid:16048353 |
| Madonna R et al. | Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. | 2005 | J. Biol. Chem. | pmid:15705589 |
| Pedrini S et al. | Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. | 2005 | PLoS Med. | pmid:15647781 |
| Cordle A and Landreth G | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. | 2005 | J. Neurosci. | pmid:15647473 |
| Hewitt RE et al. | The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. | 2005 | Clin. Exp. Immunol. | pmid:15606619 |
| Wu B et al. | Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15618546 |