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HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. |
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Molecular clues into the pathogenesis of statin-mediated muscle toxicity. |
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Muscle Nerve |
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The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. |
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Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. |
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A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. |
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Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. |
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Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? |
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Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters. |
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Toxicology |
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Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. |
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Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. |
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Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. |
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Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. |
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Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). |
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Phytochemistry |
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Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. |
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Identification of an Archaeal type II isopentenyl diphosphate isomerase in methanothermobacter thermautotrophicus. |
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Linking lipids, Alzheimer's and LXRs? |
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Nucl Recept Signal |
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A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. |
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The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). |
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Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. |
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Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. |
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Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. |
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Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. |
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Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. |
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Update on statins: 2003. |
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Circulation |
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Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells. |
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Br. J. Pharmacol. |
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Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. |
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Effects of pravastatin on the expression of ATP-binding cassette transporter A1. |
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Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. |
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Arthritis Rheum. |
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Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. |
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Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. |
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Protein Sci. |
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Heterologous mevalonate production in Streptomyces lividans TK23. |
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Biosci. Biotechnol. Biochem. |
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Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. |
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Biochemistry |
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Cancer Res. |
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Origins and evolution of isoprenoid lipid biosynthesis in archaea. |
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Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. |
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Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. |
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The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. |
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Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. |
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Metabolism and function of coenzyme Q. |
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Biochim. Biophys. Acta |
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Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. |
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Novel genotype of mevalonic aciduria with fatalities in premature siblings. |
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Arch. Dis. Child. Fetal Neonatal Ed. |
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Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. |
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Plant Cell |
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Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. |
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Biochim. Biophys. Acta |
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Lipid rafts mediate the synaptic localization of alpha-synuclein. |
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Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. |
2004 |
Dev. Cell |
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Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. |
2003 May-Jun |
Biotechnol. Prog. |
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Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. |
2003 |
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3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. |
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All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. |
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Atherosclerosis |
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Statins induce suppressor of cytokine signaling-3 in macrophages. |
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Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. |
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