| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peutz-Jeghers Syndrome | D010580 | 2 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
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All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kumar B et al. | Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | 2002 | J. Neurosci. Res. | pmid:12111853 |
| Frenkel J et al. | Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | 2002 | Arthritis Rheum. | pmid:12384940 |
| Nwokoro NA et al. | Genetic disorders of cholesterol biosynthesis in mice and humans. | 2001 Sep-Oct | Mol. Genet. Metab. | pmid:11592808 |
| Sul D and Kaneshiro ES | Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. | 2001 Mar-Apr | J. Eukaryot. Microbiol. | pmid:12095106 |
| Haas D et al. | Inherited disorders of cholesterol biosynthesis. | 2001 | Neuropediatrics | pmid:11521206 |
| Ichiki T et al. | Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11742861 |
| Rasmussen LM et al. | Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. | 2001 | Biochem. J. | pmid:11716764 |
| Diomede L et al. | In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11498461 |
| Fujita T et al. | Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. | 2001 | Jpn. J. Pharmacol. | pmid:11430477 |
| Eberlein M et al. | Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). | 2001 | Br. J. Pharmacol. | pmid:11487529 |
| Altincicek B et al. | LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. | 2001 | FEBS Lett. | pmid:11418107 |
| McCarty MF | Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. | 2001 | Med. Hypotheses | pmid:11425277 |
| Yasunari K et al. | HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11397700 |
| Stalker TJ et al. | A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. | 2001 | Br. J. Pharmacol. | pmid:11375257 |
| MartÃnez-González J et al. | 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11348878 |
| Takemoto M et al. | NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. | 2001 | Br. J. Pharmacol. | pmid:11325797 |
| Houten SM et al. | Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. | 2001 | Eur. J. Hum. Genet. | pmid:11313768 |
| Sharkey TD et al. | Isoprene increases thermotolerance of fosmidomycin-fed leaves. | 2001 | Plant Physiol. | pmid:11299379 |
| Dimitroulakos J et al. | Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. | 2001 | Clin. Cancer Res. | pmid:11205904 |
| Zeidler J and Lichtenthaler HK | Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. | 2001 | Planta | pmid:11469599 |
| Dunford JE et al. | Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11160603 |
| Izumo N et al. | Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. | 2001 | Methods Find Exp Clin Pharmacol | pmid:11771853 |
| Ginger ML et al. | The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana. | 2001 | J. Biol. Chem. | pmid:11148203 |
| Luo JD et al. | Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes. | 2001 | Br. J. Pharmacol. | pmid:11156573 |
| Archelas A and Furstoss R | Synthetic applications of epoxide hydrolases. | 2001 | Curr Opin Chem Biol | pmid:11282336 |
| Wong B et al. | Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. | 2001 | J. Leukoc. Biol. | pmid:11404382 |
| O'Neill FH et al. | Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11348882 |
| Hjertman M et al. | Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11676505 |
| Ferri N et al. | Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. | 2001 | Biochem. Pharmacol. | pmid:11755117 |
| Karunagoda RP et al. | Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440120 |
| Suri S et al. | Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. | 2001 | Bone | pmid:11595616 |
| Gan X et al. | Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. | 2001 | J. Biol. Chem. | pmid:11641412 |
| Hahn FM et al. | 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. | 2001 | J. Bacteriol. | pmid:11114895 |
| Laffitte BA et al. | LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11149950 |
| Fellermeier M et al. | Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. | 2001 | Eur. J. Biochem. | pmid:11733027 |
| Chmielewski M et al. | Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. | 2001 | Mol. Cell. Biochem. | pmid:11855739 |
| Dairi T et al. | Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. | 2001 | J. Bacteriol. | pmid:11567009 |
| Frenkel J et al. | Increased urinary leukotriene E(4) during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome. | 2001 | Arch. Dis. Child. | pmid:11466192 |
| Hamano Y et al. | Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11515548 |
| GarcÃa-Román N et al. | Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. | 2001 | Mol. Cell. Neurosci. | pmid:11178870 |
| MartÃnez-Botas J et al. | Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. | 2001 | Biochim. Biophys. Acta | pmid:11470239 |
| Chang JJ et al. | The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. | 2001 | Pharmacology | pmid:11359999 |
| Degraeve F et al. | Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. | 2001 | J. Biol. Chem. | pmid:11591701 |
| Blader IJ et al. | Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. | 2001 | J. Biol. Chem. | pmid:11294868 |
| Reszka AA et al. | Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. | 2001 | Mol. Pharmacol. | pmid:11160853 |
| Hecht S et al. | Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11752431 |
| Kaneda K et al. | An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11158573 |
| Daugherty M et al. | Archaeal shikimate kinase, a new member of the GHMP-kinase family. | 2001 | J. Bacteriol. | pmid:11114929 |
| Alvarez de Sotomayor M and Andriantsitohaina R | Simvastatin and Ca(2+) signaling in endothelial cells: involvement of rho protein. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162544 |
| Chamberlain LH | Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. | 2001 | FEBS Lett. | pmid:11696371 |
| Campos N et al. | Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. | 2001 | Biochem. J. | pmid:11115399 |
| Sapkota GP et al. | Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. | 2001 | J. Biol. Chem. | pmid:11297520 |
| Scoppola A et al. | Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. | 2001 | Atherosclerosis | pmid:11395032 |
| Shukolyukov SA and Saakov VS | American cockroach (Periplaneta americana) synthesizes carotenoids from the precursor. | 2001 | Biochemistry Mosc. | pmid:11405890 |
| Altincicek B et al. | GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. | 2001 | J. Bacteriol. | pmid:11274098 |
| Chiang JY et al. | Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). | 2001 | Gene | pmid:11179691 |
| Jagdev SP et al. | The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. | 2001 | Br. J. Cancer | pmid:11308265 |
| Bede JC et al. | Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. | 2001 | Plant Physiol. | pmid:11598232 |
| Eisenreich W et al. | Deoxyxylulose phosphate pathway to terpenoids. | 2001 | Trends Plant Sci. | pmid:11173292 |
| Jenkins DJ et al. | Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. | 2001 | Metab. Clin. Exp. | pmid:11288049 |
| Rohdich F et al. | The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. | 2001 | Curr Opin Chem Biol | pmid:11578926 |
| Lange BM et al. | Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. | 2001 | Plant Physiol. | pmid:11553758 |
| Skaletz-Rorowski A et al. | Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. | 2001 | Eur. J. Cell Biol. | pmid:11322384 |
| Zhang Z et al. | Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. | 2001 | J. Lipid Res. | pmid:11290837 |
| Schwender J et al. | Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. | 2001 | Planta | pmid:11289606 |
| Asada Y et al. | Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway. | 2000 | Phytochemistry | pmid:11117880 |
| Hausding M et al. | Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. | 2000 | Br. J. Pharmacol. | pmid:11015307 |
| Bergstrom JD et al. | Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. | 2000 | Arch. Biochem. Biophys. | pmid:10620343 |
| Kuzuyama T et al. | Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. | 2000 | J. Bacteriol. | pmid:10648511 |
| Vishnuvardhan D and Beinfeld MC | Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. | 2000 | Peptides | pmid:10822111 |
| Smit A and Mushegian A | Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway. | 2000 | Genome Res. | pmid:11042147 |
| Wagner AH et al. | Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10634801 |
| Itoh D et al. | Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. | 2000 | J. Nat. Prod. | pmid:10978203 |
| Lindenthal B and von Bergmann K | Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. | 2000 | Metab. Clin. Exp. | pmid:10647065 |
| Takagi M et al. | A gene cluster for the mevalonate pathway from Streptomyces sp. Strain CL190. | 2000 | J. Bacteriol. | pmid:10894721 |
| Wilding EI et al. | Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. | 2000 | J. Bacteriol. | pmid:10894743 |
| Woo JT et al. | Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. | 2000 | J. Bone Miner. Res. | pmid:10780857 |
| Haratake A et al. | Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. | 2000 | J. Invest. Dermatol. | pmid:10651982 |
| Tanaka T et al. | Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 2000 | J. Neurosci. | pmid:10751437 |
| Tasevski V et al. | Mitogenic effect of lithium in FRTL-5 cells can be reversed by blocking de novo cholesterol synthesis and subsequent signal transduction. | 2000 | Thyroid | pmid:10807058 |
| Hernández-Perera O et al. | Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. | 2000 | Circ. Res. | pmid:11009568 |
| Schulte AE et al. | Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don. | 2000 | Arch. Biochem. Biophys. | pmid:10860546 |
| Palinski W | Immunomodulation: a new role for statins? | 2000 | Nat. Med. | pmid:11100105 |
| Cvejić JH and Rohmer M | CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. | 2000 | Phytochemistry | pmid:10656403 |
| Kim SI et al. | Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. | 2000 | J. Am. Soc. Nephrol. | pmid:10616843 |
| Hanley K et al. | Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. | 2000 | J. Invest. Dermatol. | pmid:10692116 |
| Raal FJ et al. | Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. | 2000 | Atherosclerosis | pmid:10856535 |
| Aboushadi N et al. | Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. | 2000 | Biochemistry | pmid:10625499 |
| Szkopińska A et al. | The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623644 |
| Alvarez De Sotomayor M et al. | Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. | 2000 | Br. J. Pharmacol. | pmid:11082126 |
| Stickney JT and Buss JE | Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. | 2000 | Mol. Biol. Cell | pmid:10888661 |
| Montalvetti A et al. | Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase. | 2000 | Biochem. J. | pmid:10861207 |
| Ashar HR et al. | Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. | 2000 | J. Biol. Chem. | pmid:10852915 |
| Chen H et al. | Fluvastatin upregulates inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells. | 2000 | Hypertension | pmid:11116101 |
| Turunen M et al. | Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. | 2000 | J. Mol. Biol. | pmid:10731415 |
| Hashimoto F et al. | Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. | 2000 | Biochem. Pharmacol. | pmid:10736420 |
| Flach J et al. | The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733934 |
| RodrÃguez-Concepción M et al. | Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. | 2000 | FEBS Lett. | pmid:10818234 |
| Coppens I et al. | Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. | 2000 | J. Cell Biol. | pmid:10747095 |
| Leonardsen L et al. | Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. | 2000 | J. Reprod. Fertil. | pmid:10793639 |