Kistowska M et al. |
Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. |
2008 |
Eur. J. Immunol. |
pmid:18624305
|
|
|
|
|
pmid:18635753
|
|
|
|
|
pmid:18653353
|
Lüdke SM et al. |
Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2008 |
J. Lipid Res. |
pmid:18669481
|
Laezza C et al. |
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. |
2008 |
Endocr. Relat. Cancer |
pmid:18676619
|
Oliveira KA et al. |
Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. |
2008 |
J. Bioenerg. Biomembr. |
pmid:18679777
|
Pscheidt B and Glieder A |
Yeast cell factories for fine chemical and API production. |
2008 |
Microb. Cell Fact. |
pmid:18684335
|
Kotti T et al. |
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18685105
|
Sando T et al. |
Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18685207
|
Acharjee S and Welty FK |
Atorvastatin and cardiovascular risk in the elderly--patient considerations. |
2008 |
Clin Interv Aging |
pmid:18686752
|
Sławińska A and Kandefer-Szerszeń M |
[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
pmid:18688209
|
|
|
|
|
pmid:18692592
|
Ness GC et al. |
Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels. |
1991 |
J. Biol. Chem. |
pmid:1869523
|
Begley M et al. |
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. |
2008 |
Infect. Immun. |
pmid:18765739
|
Kaliszewski P et al. |
Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. |
2008 |
Biochim. Biophys. Acta |
pmid:18771750
|
Anthony JR et al. |
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. |
2009 |
Metab. Eng. |
pmid:18775787
|
Habeos IG et al. |
Simvastatin activates Keap1/Nrf2 signaling in rat liver. |
2008 |
J. Mol. Med. |
pmid:18787804
|
Bate C et al. |
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. |
2008 |
BMC Biol. |
pmid:18789130
|
Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
pmid:18792797
|
Olson AL et al. |
Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. |
2009 |
Proteins |
pmid:18798562
|
Voynova NE et al. |
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. |
2008 |
Arch. Biochem. Biophys. |
pmid:18823933
|
Sepp-Lorenzino L et al. |
Cell-cycle-dependent, differential prenylation of proteins. |
1991 |
Eur. J. Biochem. |
pmid:1889420
|
Xiang Z and Reeves SA |
Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. |
2009 |
Exp. Neurol. |
pmid:18929563
|
|
|
|
|
pmid:18941711
|
Domoki F et al. |
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. |
2009 |
Am. J. Physiol., Cell Physiol. |
pmid:18971391
|
Vögeli U and Chappell J |
Inhibition of a plant sesquiterpene cyclase by mevinolin. |
1991 |
Arch. Biochem. Biophys. |
pmid:1898013
|
Kimura T et al. |
Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. |
2008 |
J. Immunol. |
pmid:18981156
|
Sapir-Mir M et al. |
Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. |
2008 |
Plant Physiol. |
pmid:18988695
|
Winegar DA et al. |
Isoprenylation of rap2 proteins in platelets and human erythroleukemia cells. |
1991 |
J. Biol. Chem. |
pmid:1900292
|
Monzack EL et al. |
Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19023089
|
Kervizic G and Corcos L |
Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. |
2008 |
BMC Syst Biol |
pmid:19025648
|
GarcÃa I et al. |
QSAR and complex network study of the chiral HMGR inhibitor structural diversity. |
2009 |
Bioorg. Med. Chem. |
pmid:19026553
|
Balibar CJ et al. |
The mevalonate pathway of Staphylococcus aureus. |
2009 |
J. Bacteriol. |
pmid:19028897
|
Sanford J et al. |
Gamma-subunits of G proteins, but not their alpha- or beta-subunits, are polyisoprenylated. Studies on post-translational modifications using in vitro translation with rabbit reticulocyte lysates. |
1991 |
J. Biol. Chem. |
pmid:1903391
|
Rekittke I et al. |
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. |
2008 |
J. Am. Chem. Soc. |
pmid:19035630
|
|
|
|
|
pmid:19053515
|
|
|
|
|
pmid:19053857
|
Fujimoto M et al. |
Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. |
2009 |
Eur. J. Pharmacol. |
pmid:19059394
|
Farnsworth CC et al. |
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1906176
|
Mizuno T et al. |
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1907371
|
|
|
|
|
pmid:19083230
|
Roitelman J et al. |
Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. |
1991 |
J. Biol. Chem. |
pmid:1908464
|
|
|
|
|
pmid:191001
|
Abumweis SS et al. |
Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. |
2008 |
Food Nutr Res |
pmid:19109655
|
Schwartz YSh et al. |
Cholesterol-induced stimulation of postinflammatory liver fibrosis. |
2008 |
Bull. Exp. Biol. Med. |
pmid:19110552
|
Lindemann CJ et al. |
Determination of mevalonolactone in capsules by capillary gas-liquid chromatography. |
1991 |
J Pharm Biomed Anal |
pmid:1911983
|
Dje N'Guessan P et al. |
Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19122173
|
Deshpande G et al. |
Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. |
2009 |
PLoS Genet. |
pmid:19132091
|
Ohyama K et al. |
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. |
2009 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:19139393
|
Rydgren T and Sandler S |
The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19150339
|
Knight LA et al. |
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. |
2009 |
BMC Cancer |
pmid:19175937
|
Fujiyama A et al. |
S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. |
1991 |
J. Biol. Chem. |
pmid:1917931
|
Cuthbert JA and Lipsky PE |
Negative regulation of cell proliferation by mevalonate or one of the mevalonate phosphates. |
1991 |
J. Biol. Chem. |
pmid:1917936
|
Löw P et al. |
The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues. |
1991 |
J. Biol. Chem. |
pmid:1918042
|
Zeiser R et al. |
Regulation of different inflammatory diseases by impacting the mevalonate pathway. |
2009 |
Immunology |
pmid:19191903
|
|
|
|
|
pmid:19198899
|
Kim WY et al. |
Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. |
2009 |
J. Neurochem. |
pmid:19209406
|
|
|
|
|
pmid:19219049
|
Tsuruta H et al. |
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. |
2009 |
PLoS ONE |
pmid:19221601
|
Lin Y et al. |
Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. |
2011 |
Evid Based Complement Alternat Med |
pmid:19228775
|
Lachmann HJ and Hawkins PN |
Developments in the scientific and clinical understanding of autoinflammatory disorders. |
2009 |
Arthritis Res. Ther. |
pmid:19232070
|
Yeger-Lotem E et al. |
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. |
2009 |
Nat. Genet. |
pmid:19234470
|
Niessen J et al. |
Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. |
2009 |
Drug Metab. Dispos. |
pmid:19237515
|
Kinsella BT et al. |
Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1924354
|
|
|
|
|
pmid:19254730
|
Maeda T and Horiuchi N |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. |
2009 |
J. Biochem. |
pmid:19254925
|
Ledezma E et al. |
Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. |
2009 |
Melanoma Res. |
pmid:19276863
|
Ellsworth JL et al. |
Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells. |
1991 |
Biochem. J. |
pmid:1930137
|
Alvarez Y et al. |
Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:19318593
|
Khan MA et al. |
Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. |
2009 |
J. Immunol. |
pmid:19342651
|
|
|
|
|
pmid:19346993
|
|
|
|
|
pmid:19360315
|
Suzuki M et al. |
Complete blockage of the mevalonate pathway results in male gametophyte lethality. |
2009 |
J. Exp. Bot. |
pmid:19363204
|
|
|
|
|
pmid:19384817
|
Sun X et al. |
Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. |
2009 |
Bioresour. Technol. |
pmid:19386490
|
Scoppola A et al. |
Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry. |
1991 |
J. Lipid Res. |
pmid:1940620
|
Elmberger PG et al. |
Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia. |
1991 |
J. Lipid Res. |
pmid:1940625
|
Sillero MA et al. |
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. |
2009 |
Biochem. Pharmacol. |
pmid:19414000
|
|
|
|
|
pmid:19414014
|
Rothwell C et al. |
Cholesterol biosynthesis modulation regulates dengue viral replication. |
2009 |
Virology |
pmid:19419745
|
Raemer PC et al. |
Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. |
2009 |
Eur. J. Immunol. |
pmid:19424968
|
|
|
|
|
pmid:19428716
|
Kato S et al. |
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. |
2010 |
J. Cell. Mol. Med. |
pmid:19432822
|
Epstein WW et al. |
Quantitation of prenylcysteines by a selective cleavage reaction. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1946384
|
Li J et al. |
Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. |
2009 |
J. Immunol. |
pmid:19494338
|
|
|
|
|
pmid:19508172
|
Mansouri H et al. |
Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. |
2009 |
J Integr Plant Biol |
pmid:19522814
|
Bełtowski J et al. |
Adverse effects of statins - mechanisms and consequences. |
2009 |
Curr Drug Saf |
pmid:19534648
|
|
|
|
|
pmid:1953779
|
Montoya CJ et al. |
Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. |
2009 |
Trials |
pmid:19538732
|
Sidorkiewicz M et al. |
Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. |
2009 |
Virus Res. |
pmid:19540284
|
Hashimoto F and Hayashi H |
Identification of intermediates after inhibition of cholesterol synthesis by aminotriazole treatment in vivo. |
1991 |
Biochim. Biophys. Acta |
pmid:1954238
|
Yoon HE and Yang CW |
Established and newly proposed mechanisms of chronic cyclosporine nephropathy. |
2009 |
Korean J. Intern. Med. |
pmid:19543484
|
Perttilä J et al. |
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. |
2009 |
J. Mol. Med. |
pmid:19554302
|
Kroll J et al. |
Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. |
2009 |
Metab. Eng. |
pmid:19558962
|
Minichsdorfer C and Hohenegger M |
Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. |
2009 |
Br. J. Pharmacol. |
pmid:19563533
|
Zeki AA et al. |
Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. |
2009 |
Am. J. Respir. Crit. Care Med. |
pmid:19608720
|
Yoshida T et al. |
Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
2008 |
Anal Chem Insights |
pmid:19609389
|
Lorenzen W et al. |
Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. |
2009 |
J. Bacteriol. |
pmid:19617362
|
Yang Z et al. |
Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. |
2010 |
Int. J. Cancer |
pmid:19626588
|