Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Saito Y et al. Animal cell mutants defective in sterol metabolism: a specific selection procedure and partial characterization of defects. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:269426
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Huneeus VQ et al. Isopentenyladenine as a mediator of mevalonate-regulated DNA replication. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6934516
Kopito RR and Brunengraber H (R)-mevalonate excretion in human and rat urines. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6255462
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Dudareva N et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15630092
Hampton RY and Bhakta H Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9371780
McNamara DJ et al. Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:268653
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Matsumoto Y et al. A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. 2016 Sci Rep pmid:26961421
Pina ES et al. Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. 2016 Sci Rep pmid:26943243
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Warita K et al. Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. 2014 Sci Rep pmid:25534349
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Edmond J et al. Mevalonate metabolism: role of kidneys. 1976 Science pmid:935865
Farnsworth CC et al. Identification of geranylgeranyl-modified proteins in HeLa cells. 1990 Science pmid:2296721
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Yi P et al. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. 2006 Science pmid:16857902
Galli G et al. Sterol precursors of cholesterol in adult human brain. 1968 Science pmid:5700071
Jomaa H et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. 1999 Science pmid:10477522
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Ginestier C et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. 2012 Stem Cells pmid:22605458
Lee MH et al. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. 2007 Stem Cells pmid:17464088
Honda A et al. Effect of YM 9429, a potent teratogen, on cholesterol biosynthesis in cultured cells and rat liver microsomes. 1996 Steroids pmid:8883221
Richardson B et al. Sterol metabolism in normal and tobacco mosaic virus-infected tobacco plants. 1968 Steroids pmid:5642319
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Abernethy D et al. In vitro inhibition of rat liver cholest-5en-3 beta-ol (cholesterol) biosynthesis by non-mercurial sulfhydryl reagents. 1976 Steroids pmid:1265795
Subbiah MT Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: effect of plasma and individual lipoproteins. 1980 Steroids pmid:7444999
Muñoz-García B et al. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. 2006 Stroke pmid:16809572
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Harrison LE et al. Phenylacetate inhibits isoprenoid biosynthesis and suppresses growth of human pancreatic carcinoma. 1998 Surgery pmid:9736908
Hrab RV et al. Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation. 1994 Teratology pmid:7974251
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Chida N and Okamura T Increased cholesterol-biosynthesis in familial hypercholesterolemia. 1971 Tohoku J. Exp. Med. pmid:5140375
Nishimoto T et al. Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. 2007 Toxicol. Appl. Pharmacol. pmid:17599378
Murphy LA et al. Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. 2012 Toxicol. Appl. Pharmacol. pmid:22361350
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