Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Elliott JG and Lachance PA Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. 1980 J. Nutr. pmid:7381607
Yu SG et al. Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. 1995 J. Nutr. pmid:7472655
Bell FP et al. L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits. 1992 J. Nutr. pmid:1552371
Fillios LC et al. Synthesis and distribution of cholesterol, and the effect of diet, at the liver endoplasmic reticula and plasma membranes from lean or obese rats. 1969 J. Nutr. pmid:5784252
Mukherjee C et al. In vitro studies on the effect of different dietary fats and different proportions of dietary protein on the synthesis of lipids by rat arterial tissue. 1971 J. Nutr. pmid:5578922
Peffley DM and Gayen AK Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. 2003 J. Nutr. pmid:12514264
He L et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. 1997 J. Nutr. pmid:9164984
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Grossi-Paoletti E et al. Lipids in brain tumors. 1971 J. Neurosurg. pmid:4323146
Kumar B et al. Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. 2002 J. Neurosci. Res. pmid:12111853
Michikawa M and Yanagisawa K Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. 1998 J. Neurosci. Res. pmid:9778150
Braun PE et al. Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes. 1991 J. Neurosci. Res. pmid:1666129
Rattan R et al. Rho/ROCK pathway as a target of tumor therapy. 2006 J. Neurosci. Res. pmid:16385577
Zacco A et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. 2003 J. Neurosci. pmid:14657168
Tanaka T et al. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. 2000 J. Neurosci. pmid:10751437
Cordle A and Landreth G 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. 2005 J. Neurosci. pmid:15647473
Fortin DL et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. 2004 J. Neurosci. pmid:15282274
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
Langan TJ and Volpe JJ Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures. 1987 J. Neurochem. pmid:3648095
Jones JP et al. Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. 1975 J. Neurochem. pmid:1110355
Rostas JA et al. Selective labelling of two phases of axonal transport of cholesterol in the chick optic system. 1979 J. Neurochem. pmid:86598
Sliwowski JK et al. The in vivo biosynthesis of cholesterol from (3RS,2R) [2-14C,2-3H]mevalonic acid in the brains of rats on normal and protein deficient diets. The stereochemistry of tritium atoms at C-7 and C-15. 1977 J. Neurochem. pmid:874493
Langan TJ and Volpe JJ Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate. 1987 J. Neurochem. pmid:3033149
Menkes JH Lipid metabolism in brain tissue explants. 1971 J. Neurochem. pmid:5092865
Hughes M et al. Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. 2010 J. Neurochem. pmid:20477946
Chevallier F and Gautheron C A method for the study of cholesterol biosynthesis in the central nervous system. Incorporation of [2-14C]mevalonic lactone after intraperitoneal, intracisternal and intraventricular administration in the rat. 1969 J. Neurochem. pmid:5795585
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. 1972 J. Neurochem. pmid:5009889
Parsons RB et al. A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. 2007 J. Neurochem. pmid:17472704
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. 1971 J. Neurochem. pmid:5092868
Kim WY et al. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. 2009 J. Neurochem. pmid:19209406
Michikawa M and Yanagisawa K Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. 1999 J. Neurochem. pmid:10349836
Weiss JF et al. Sterols with 29, 28 and 27 carbon atoms metabolically related to cholesterol, occurring in developing and mature brain. 1968 J. Neurochem. pmid:5675585
Schedin S et al. Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. 1995 J. Neurochem. pmid:7616223
Jones JP et al. The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats. 1975 J. Neurochem. pmid:1167373
Volpe JJ and Obert KA Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin. 1982 J. Neurochem. pmid:7062041
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Jeng I et al. Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A. 1984 J. Neurochem. pmid:6567656
Crick DC et al. Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. 1995 J. Neurochem. pmid:7643114
Heacock AM et al. Cholesterol synthesis and nerve regeneration. 1984 J. Neurochem. pmid:6699648
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of (2- 14 C)mevalonic acid into 30-day-old rat brain: a period of transition. 1972 J. Neurochem. pmid:5019590
Surup F et al. Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. 2015 J. Nat. Prod. pmid:25871540
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Itoh D et al. Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. 2000 J. Nat. Prod. pmid:10978203
Itoh D et al. Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. 2003 J. Nat. Prod. pmid:12662088
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Habeos IG et al. Simvastatin activates Keap1/Nrf2 signaling in rat liver. 2008 J. Mol. Med. pmid:18787804
Turunen M et al. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. 2000 J. Mol. Biol. pmid:10731415
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Brown GR et al. Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8709131
Douglass TS et al. The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab. 1981 J. Lipid Res. pmid:7276755
Feingold KR et al. The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. 1981 J. Lipid Res. pmid:7276756
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Doerner KC et al. Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. 1995 J. Lipid Res. pmid:7665995
Brown MS and Goldstein JL Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. 1980 J. Lipid Res. pmid:6995544
Langdon R et al. Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol. 1977 J. Lipid Res. pmid:833506
Kekki M et al. Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man. 1977 J. Lipid Res. pmid:833511
Risé P et al. Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. 1997 J. Lipid Res. pmid:9254057
Honda A et al. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. 2007 J. Lipid Res. pmid:17272831
Gaskin F and Clayton RB An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. 1972 J. Lipid Res. pmid:4400581
Lüdke SM et al. Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2008 J. Lipid Res. pmid:18669481
Field FJ et al. Regulation of cholesterol esterification by micellar cholesterol in CaCo-2 cells. 1987 J. Lipid Res. pmid:3655559
Kopito RR et al. Metabolism of plasma mevalonate in rats and humans. 1982 J. Lipid Res. pmid:7097123
Brunengraber H et al. Urinary clearance and metabolism of mevalonate by the isolataed perfused rat kidney. 1981 J. Lipid Res. pmid:7276751
Stone BG and Evans CD Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver. 1992 J. Lipid Res. pmid:1464750
Naoumova RP et al. Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. 1997 J. Lipid Res. pmid:9254075
Kuo KK et al. Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss. 2015 J. Lipid Res. pmid:26351364
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Brannan PG et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots. 1975 J. Lipid Res. pmid:162931
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Shefer S et al. Diurnal variation of HMG CoA reductase activity in rat intestine. 1972 J. Lipid Res. pmid:5075502
Burki E et al. Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein. 1987 J. Lipid Res. pmid:3681144
Cenedella RJ and Fleschner CR Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development. 1989 J. Lipid Res. pmid:2794790
Hulcher FH and Oleson WH Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. 1973 J. Lipid Res. pmid:4147523
Thompson GR et al. Role of cholesterol in regulating apolipoprotein B secretion by the liver. 1996 J. Lipid Res. pmid:8728309
Goldfarb S and Pitot HC Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase. 1972 J. Lipid Res. pmid:4641420
Pandak WM et al. Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis. 1990 J. Lipid Res. pmid:1708805
Dietschy JM and Brown MS Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis. 1974 J. Lipid Res. pmid:4413018
Kasim SE et al. Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat. 1992 J. Lipid Res. pmid:1552226
Erickson SK et al. Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats. 1989 J. Lipid Res. pmid:2614275
Raskin P and Siperstein MD Mevalonate metabolism by renal tissue in vitro. 1974 J. Lipid Res. pmid:4811213
Gaylor JL et al. Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. 1966 J. Lipid Res. pmid:4290536
Gould RG and Swyryd EA Sites of control of hepatic cholesterol biosynthesis. 1966 J. Lipid Res. pmid:5971049
Elwood JC and Morris HP Lack of adaptation in lipogenesis by hepatoma 9121. 1968 J. Lipid Res. pmid:4296416
Holstein SA and Hohl RJ Monoterpene regulation of Ras and Ras-related protein expression. 2003 J. Lipid Res. pmid:12671036
Nicolau G et al. Determination of hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in man. 1974 J. Lipid Res. pmid:4811219
Goodwin CD and Margolis S Improved methods for the study of hepatic HMG CoA reductase: one-step isolation of mevalonolactone and rapid preparation of endoplasmic reticulum. 1976 J. Lipid Res. pmid:6605
Ockner RK and Laster L Biosynthesis of delta-7-cholesten-3-beta-ol, delta-5,7-cholestadien-3-beta-ol, and delta-5-cholesten-3-beta-ol by guinea pig intestinal mucosa in vitro. 1966 J. Lipid Res. pmid:5971571
Barter PJ Origin of esterified cholesterol transported in the very low density lipoproteins of human plasma. 1974 J. Lipid Res. pmid:4359537
Hidaka Y et al. Regulation of squalene epoxidase in HepG2 cells. 1990 J. Lipid Res. pmid:1964954
Popják G et al. Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts. 1985 J. Lipid Res. pmid:2411835
Brady PS et al. Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. 1983 J. Lipid Res. pmid:6415196
Popják G et al. Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man. 1979 J. Lipid Res. pmid:226640
Logan DM Thermal and pH stability of 2 -isopentenyl pyrophosphate. 1972 J. Lipid Res. pmid:4333821
Wilson WK et al. Determination of the enantiomeric purity of mevalonolactone via NMR using a chiral lanthanide shift reagent. 1982 J. Lipid Res. pmid:7097129
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322
Taddeini L et al. Acceleration of hepatic sterol synthesis after a single dose of the porphyrogenic chemical allylisopropylacetamide. 1974 J. Lipid Res. pmid:4811218
Klauda HC and Zilversmit DB Influx of cholesterol into plasma in rabbits with fasting hyperbetalipoproteinemia. 1974 J. Lipid Res. pmid:4372287
Zhang Z et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. 2001 J. Lipid Res. pmid:11290837
Field FJ and Mathur SN Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells. 1983 J. Lipid Res. pmid:6631233