Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Douglass TS et al. The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab. 1981 J. Lipid Res. pmid:7276755
Feingold KR et al. The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. 1981 J. Lipid Res. pmid:7276756
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Doerner KC et al. Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. 1995 J. Lipid Res. pmid:7665995
Cayen MN and Dvornik D Effect of diosgenin on lipid metabolism in rats. 1979 J. Lipid Res. pmid:438658
Scoppola A et al. Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry. 1991 J. Lipid Res. pmid:1940620
Brown MS and Goldstein JL Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. 1980 J. Lipid Res. pmid:6995544
Langdon R et al. Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol. 1977 J. Lipid Res. pmid:833506
Kekki M et al. Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man. 1977 J. Lipid Res. pmid:833511
Risé P et al. Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. 1997 J. Lipid Res. pmid:9254057
Gaskin F and Clayton RB An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. 1972 J. Lipid Res. pmid:4400581
Field FJ et al. Regulation of cholesterol esterification by micellar cholesterol in CaCo-2 cells. 1987 J. Lipid Res. pmid:3655559
Kopito RR et al. Metabolism of plasma mevalonate in rats and humans. 1982 J. Lipid Res. pmid:7097123
Brunengraber H et al. Urinary clearance and metabolism of mevalonate by the isolataed perfused rat kidney. 1981 J. Lipid Res. pmid:7276751
Stone BG and Evans CD Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver. 1992 J. Lipid Res. pmid:1464750
Naoumova RP et al. Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. 1997 J. Lipid Res. pmid:9254075
Kuo KK et al. Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss. 2015 J. Lipid Res. pmid:26351364
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Shefer S et al. Diurnal variation of HMG CoA reductase activity in rat intestine. 1972 J. Lipid Res. pmid:5075502
Burki E et al. Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein. 1987 J. Lipid Res. pmid:3681144
Cenedella RJ and Fleschner CR Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development. 1989 J. Lipid Res. pmid:2794790
Pappu AS et al. Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. 2002 J. Lipid Res. pmid:12364550
Hulcher FH and Oleson WH Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. 1973 J. Lipid Res. pmid:4147523
Thompson GR et al. Role of cholesterol in regulating apolipoprotein B secretion by the liver. 1996 J. Lipid Res. pmid:8728309
Goldfarb S and Pitot HC Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase. 1972 J. Lipid Res. pmid:4641420
Pandak WM et al. Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis. 1990 J. Lipid Res. pmid:1708805
Dietschy JM and Brown MS Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis. 1974 J. Lipid Res. pmid:4413018
Erickson SK et al. Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats. 1989 J. Lipid Res. pmid:2614275
Goldfarb S and Pitot HC Improved assay of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1971 J. Lipid Res. pmid:5164097
Raskin P and Siperstein MD Mevalonate metabolism by renal tissue in vitro. 1974 J. Lipid Res. pmid:4811213
Elmberger PG et al. Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia. 1991 J. Lipid Res. pmid:1940625
Gaylor JL et al. Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. 1966 J. Lipid Res. pmid:4290536
Gould RG and Swyryd EA Sites of control of hepatic cholesterol biosynthesis. 1966 J. Lipid Res. pmid:5971049
Nicolau G et al. Determination of hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in man. 1974 J. Lipid Res. pmid:4811219
Goodwin CD and Margolis S Improved methods for the study of hepatic HMG CoA reductase: one-step isolation of mevalonolactone and rapid preparation of endoplasmic reticulum. 1976 J. Lipid Res. pmid:6605
Saini GS et al. Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. 2006 J. Lipid Res. pmid:16861623
Barter PJ Origin of esterified cholesterol transported in the very low density lipoproteins of human plasma. 1974 J. Lipid Res. pmid:4359537
Hidaka Y et al. Regulation of squalene epoxidase in HepG2 cells. 1990 J. Lipid Res. pmid:1964954
Popják G et al. Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts. 1985 J. Lipid Res. pmid:2411835
Brady PS et al. Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. 1983 J. Lipid Res. pmid:6415196
Popják G et al. Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man. 1979 J. Lipid Res. pmid:226640
Logan DM Thermal and pH stability of 2 -isopentenyl pyrophosphate. 1972 J. Lipid Res. pmid:4333821
Cartwright IJ et al. Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes. 1997 J. Lipid Res. pmid:9101434
Wilson WK et al. Determination of the enantiomeric purity of mevalonolactone via NMR using a chiral lanthanide shift reagent. 1982 J. Lipid Res. pmid:7097129
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322
Taddeini L et al. Acceleration of hepatic sterol synthesis after a single dose of the porphyrogenic chemical allylisopropylacetamide. 1974 J. Lipid Res. pmid:4811218
Klauda HC and Zilversmit DB Influx of cholesterol into plasma in rabbits with fasting hyperbetalipoproteinemia. 1974 J. Lipid Res. pmid:4372287
Zhang Z et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. 2001 J. Lipid Res. pmid:11290837
Field FJ and Mathur SN Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells. 1983 J. Lipid Res. pmid:6631233
Wong B et al. Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. 2001 J. Leukoc. Biol. pmid:11404382
Terkeltaub R et al. Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells. 1994 J. Leukoc. Biol. pmid:8195701
Nantais DE et al. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. 1996 J. Leukoc. Biol. pmid:8830800
Zhao Y et al. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. 2011 J. Invest. Dermatol. pmid:21390048
Haratake A et al. Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. 2000 J. Invest. Dermatol. pmid:10651982
Hanley K et al. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. 2000 J. Invest. Dermatol. pmid:10692116
Black HS and Rauschkolb EW Effects of light on skin lipid metabolism. 1971 J. Invest. Dermatol. pmid:5556527
Vega GL et al. Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol. 1999 J. Intern. Med. pmid:10447220
Goodfellow RD et al. Dietary sterol effects on mevalonate kinase activity in axenic and non-axenic Sarcophaga bullata (Diptera). 1971 J. Insect Physiol. pmid:5111035
Mitlin N and Hedin PA Biosynthesis of grandlure, the pheromone of the boll weevil, Anthonomus grandis, from acetate, mevalonate, and glucose. 1974 J. Insect Physiol. pmid:4412207
Bretón Martínez JR et al. Mevalonic aciduria: report of two cases. 2007 J. Inherit. Metab. Dis. pmid:17578678
Roullet JB et al. No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. 2012 J. Inherit. Metab. Dis. pmid:22391996
Peng LF et al. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. 2011 J. Infect. Dis. pmid:21791663
Tyurin M Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. 2013 J. Ind. Microbiol. Biotechnol. pmid:23649912
Kimura T et al. Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. 2008 J. Immunol. pmid:18981156
Wang H et al. Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. 2011 J. Immunol. pmid:22013129
Nerdal PT et al. Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. 2016 J. Immunol. pmid:27619996
Daguzan C et al. Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells. 2016 J. Immunol. pmid:26819204
Kolawole EM et al. Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. 2016 J. Immunol. pmid:26773154
Healey GD et al. Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. 2016 J. Immunol. pmid:26673142
Curtiss LK and Edgington TS Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein LDL-In. 1980 J. Immunol. pmid:7410845
Cuthbert JA and Lipsky PE Sterol metabolism and lymphocyte function: inhibition of endogenous sterol biosynthesis does not prevent mitogen-induced human T lymphocyte activation. 1980 J. Immunol. pmid:6965969
Brahmachari S et al. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. 2009 J. Immunol. pmid:19812204
Shimabukuro-Vornhagen A et al. Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. 2014 J. Immunol. pmid:25311809
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Khan MA et al. Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. 2009 J. Immunol. pmid:19342651
Workalemahu G et al. Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity. 2014 J. Immunol. pmid:24943221
Zhang X et al. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 2008 J. Immunol. pmid:18453621
Santolaria T et al. Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. 2013 J. Immunol. pmid:23836057
Castella B et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. 2011 J. Immunol. pmid:21753152
Coward WR et al. Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. 2006 J. Immunol. pmid:16621994
Deanin GG et al. Role of isoprenoid metabolism in IgE receptor-mediated signal transduction. 1991 J. Immunol. pmid:1827487
Humphries GM and McConnell HM Potent immunosuppression by oxidized cholesterol. 1979 J. Immunol. pmid:368234
Streuli RA et al. Inhibition of human lymphocyte E-rosette formation by oxygenated sterols. 1979 J. Immunol. pmid:501096
Monick MM et al. Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. 2003 J. Immunol. pmid:12928415
Llacuna L et al. Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. 2011 J. Hepatol. pmid:21145825
Reiniers MJ et al. 2',7'-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. 2012 J. Hepatol. pmid:22127279
Bard M and Downing JF Genetic and biochemical aspects of yeast sterol regulation involving 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1981 J. Gen. Microbiol. pmid:7033470
Turner JA and Prebble JN Protection of cell viability and respiratory quinone levels by carotenoid in Micrococcus lysodeikticus (M. luteus). 1980 J. Gen. Microbiol. pmid:7411117
de Rosa M et al. Extremely thermophilic acidophilic bacteria convergent with Sulfolobus acidocaldarius. 1975 J. Gen. Microbiol. pmid:234504
Thorne KJ et al. An investigation by autoradiography and electron microscopy of the localization of prenols in Lactobacillus casei. 1974 J. Gen. Microbiol. pmid:4207873
Thorne KJ and Barker DC The occurrence of bactoprenol in the mesosome and plasma membranes of Lactobacillus casei and Lactobacillus plantarum. 1972 J. Gen. Microbiol. pmid:4625239
AARONSON S A ROLE FOR A STEROL AND A STEROL PRECURSOR IN THE BACTERIUM RHODOPSEUDOMONAS PALUSTRIS. 1964 J. Gen. Microbiol. pmid:14247747
Yoshida T et al. Plasma levels of mevalonate and 7alpha-hydroxy-4-cholesten-3-one in chronic liver disease. 1999 J. Gastroenterol. Hepatol. pmid:10029296
del Real G et al. Statins inhibit HIV-1 infection by down-regulating Rho activity. 2004 J. Exp. Med. pmid:15314078
Aktas O et al. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. 2003 J. Exp. Med. pmid:12629065
Gober HJ et al. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. 2003 J. Exp. Med. pmid:12538656
Yanae M et al. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. 2011 J. Exp. Clin. Cancer Res. pmid:21831290
Fu X et al. Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. 2012 J. Exp. Bot. pmid:21994170
Soto G et al. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. 2011 J. Exp. Bot. pmid:21908473