Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

Download all related citations
Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Ma Y et al. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. 2012 J. Exp. Bot. pmid:22291132
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Soto G et al. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. 2011 J. Exp. Bot. pmid:21908473
Sul D and Kaneshiro ES Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. 2001 Mar-Apr J. Eukaryot. Microbiol. pmid:12095106
Sul D and Kaneshiro ES Ubiquinone synthesis by Pneumocystis carinii: incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. 1997 Nov-Dec J. Eukaryot. Microbiol. pmid:9508445
Newton CJ et al. Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. 2002 J. Endocrinol. pmid:12098658
Spicer LJ et al. Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. 1996 J. Endocrinol. pmid:8994382
Sakoda K et al. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. 2006 J. Dent. Res. pmid:16723648
Scheller EL et al. Bisphosphonates inhibit expression of p63 by oral keratinocytes. 2011 J. Dent. Res. pmid:21551338
Kim RH et al. Bisphosphonates induce senescence in normal human oral keratinocytes. 2011 J. Dent. Res. pmid:21427353
Bernstein BA et al. Inhibition of cholesterol biosynthesis and acetyl-coenzyme A synthetase by bovine milk and orotic acid. 1977 J. Dairy Sci. pmid:23394
Coccodrilli GD et al. Effects of dietary protein on blood lipids of the calf with special reference to cholesterol. 1970 J. Dairy Sci. pmid:5485373
Steinberg D et al. Studies on the metabolic error in Refsum's disease. 1967 J. Clin. Invest. pmid:4164676
Schwartz CC et al. Central role of high density lipoprotein in plasma free cholesterol metabolism. 1982 J. Clin. Invest. pmid:6953075
Stone BG et al. Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool. 1985 J. Clin. Invest. pmid:4056052
Kita T et al. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. 1980 J. Clin. Invest. pmid:6903572
Gregory DH et al. Mechanism of secretion of biliary lipids. I. Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol. 1975 J. Clin. Invest. pmid:1109174
Salen G and Polito A Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis. 1972 J. Clin. Invest. pmid:4550120
DALY MM et al. CHOLESTEROL CONCENTRATION AND CHOLESTEROL SYNTHESIS IN AORTAS OF RATS WITH RENAL HYPERTENSION. 1963 J. Clin. Invest. pmid:14074354
Hellstrom KH et al. Studies of the in vivo metabolism of mevalonic acid in the normal rat. 1973 J. Clin. Invest. pmid:4703220
Nestel PJ and Couzens EA Turnover of individual cholesterol esters in human liver and plasma. 1966 J. Clin. Invest. pmid:5967699
Schwartz CC et al. Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate. 1993 J. Clin. Invest. pmid:8450070
Liu YP et al. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. 2014 J. Clin. Invest. pmid:24691443
Parker TS et al. Plasma mevalonate as a measure of cholesterol synthesis in man. 1984 J. Clin. Invest. pmid:6565710
Feingold KR et al. Sex difference in human mevalonate metabolism. 1980 J. Clin. Invest. pmid:7400320
McNamara DJ et al. Role of the kidneys in the metabolism of plasma mevalonate. Studies in humans and in rhesus monkeys. 1985 J. Clin. Invest. pmid:4019781
Mosbach EH et al. Bile acid synthesis in the isolated, perfused rabbit liver. 1971 J. Clin. Invest. pmid:5097576
Shefer S et al. Feedback regulation of bile-acid synthesis in the rat. Differing effects of taurocholate and tauroursocholate. 1990 J. Clin. Invest. pmid:2318973
Schwartz CC et al. Multicompartmental analysis of cholesterol metabolism in man. Quantitative kinetic evaluation of precursor sources and turnover of high density lipoprotein cholesterol esters. 1982 J. Clin. Invest. pmid:7119117
Bokoch GM and Prossnitz V Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. 1992 J. Clin. Invest. pmid:1310693
Dietschy JM The role of bile salts in controlling the rate of intestinal cholesterogenesis. 1968 J. Clin. Invest. pmid:4966200
Chorbanian AV Sterol synthesis in the human arterial intima. 1968 J. Clin. Invest. pmid:5637146
Pahan K et al. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. 1997 J. Clin. Invest. pmid:9389730
Nestel PJ and Monger EA Turnover of plasma esterified cholesterol in normocholesterolemic and hypercholesterolemic subjects and its relation to body build. 1967 J. Clin. Invest. pmid:6026102
Roullet JB et al. Mevalonate availability affects human and rat resistance vessel function. 1995 J. Clin. Invest. pmid:7615793
Feingold KR et al. Influence of thyroid hormone status on mevalonate metabolism in rats. 1980 J. Clin. Invest. pmid:7419712
GOODMAN DS THE IN VIVO TURNOVER OF INDIVIDUAL CHOLESTEROL ESTERS IN HUMAN PLASMA LIPOPROTEINS. 1964 J. Clin. Invest. pmid:14223916
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
van Leusden HA and Villee CA Formation of estrogens by hydatidiform moles in vitro. 1966 J. Clin. Endocrinol. Metab. pmid:4224151
Padayatty SJ et al. Lovastatin-induced apoptosis in prostate stromal cells. 1997 J. Clin. Endocrinol. Metab. pmid:9141529
Villanueva JA et al. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. 2013 J. Clin. Endocrinol. Metab. pmid:23386644
Frier BM and Saudek CD Cholesterol metabolism in diabetes: the effect of insulin on the kinetics of plasma squalene. 1979 J. Clin. Endocrinol. Metab. pmid:511973
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Kim J et al. 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. 2005 J. Chem. Ecol. pmid:16222778
Snoeren TA et al. The herbivore-induced plant volatile methyl salicylate negatively affects attraction of the parasitoid Diadegma semiclausum. 2010 J. Chem. Ecol. pmid:20407809
Larsson O and Wejde J Dolichol delays G1-arrest for one cell cycle in human fibroblasts subjected to depletion of serum or mevalonate. 1992 J. Cell. Sci. pmid:1487489
Peter M et al. Isoprenylation of rab proteins on structurally distinct cysteine motifs. 1992 J. Cell. Sci. pmid:1429897
Engström W et al. The effects of tunicamycin, mevinolin and mevalonic acid on HMG-CoA reductase activity and nuclear division in the myxomycete Physarum polycephalum. 1989 J. Cell. Sci. pmid:2592440
Sinensky M et al. Expression of prelamin A but not mature lamin A confers sensitivity of DNA biosynthesis to lovastatin on F9 teratocarcinoma cells. 1994 J. Cell. Sci. pmid:7983180
Sasseville AM and Raymond Y Lamin A precursor is localized to intranuclear foci. 1995 J. Cell. Sci. pmid:7738105
Sinensky M et al. The processing pathway of prelamin A. 1994 J. Cell. Sci. pmid:8175923
Marshall JD and Heiniger HJ High affinity Concanavalin A binding to sterol-depleted L cells. 1979 J. Cell. Physiol. pmid:489673
Ortiz MB et al. Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2 alpha in Swiss mouse 3T3 cells. 1995 J. Cell. Physiol. pmid:7814446
Larsson O Role of biosynthesis of cholesterol and isoprenoid derivatives in regulation of G1 progression and cell proliferation of 3T6 cells. 1987 J. Cell. Physiol. pmid:3667703
Maltese WA and Sheridan KM Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis. 1985 J. Cell. Physiol. pmid:3851809
Cutts JL et al. Role of mevalonic acid in the regulation of natural killer cell cytotoxicity. 1989 J. Cell. Physiol. pmid:2738100
Doyle JW and Kandutsch AA Requirement for mevalonate in cycling cells: quantitative and temporal aspects. 1988 J. Cell. Physiol. pmid:3170653
Doyle JW et al. Effects of growth factors on cell cycle arrest in dolichyl phosphate-depleted cultures. 1993 J. Cell. Physiol. pmid:8468363
Rearick JI et al. Human bronchial epithelial cells synthesize cholesterol sulfate during squamous differentiation in vitro. 1987 J. Cell. Physiol. pmid:3480290
Boissonneault GA and Heiniger HJ 25-Hydroxycholesterol-induced elevation in 45Ca uptake: correlation with depressed DNA synthesis. 1984 J. Cell. Physiol. pmid:6430918
Larsson O and Zetterberg A Effects of 25-hydroxycholesterol, cholesterol, and isoprenoid derivatives on the G1 progression in Swiss 3T3 cells. 1986 J. Cell. Physiol. pmid:3760035
Dell'Orco RT and Melnykovych G Lipid composition of heteroploid cells in culture: effects of prednisolone. 1970 J. Cell. Physiol. pmid:5471037
Cutts JL and Bankhurst AD Reversal of lovastatin-mediated inhibition of natural killer cell cytotoxicity by interleukin 2. 1990 J. Cell. Physiol. pmid:2246324
Coscia M et al. Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. 2010 J. Cell. Mol. Med. pmid:19818098
Kato S et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. 2010 J. Cell. Mol. Med. pmid:19432822
Kizu A et al. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. 2004 J. Cell. Biochem. pmid:15389884
Scheller EL et al. Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. 2011 J. Cell. Biochem. pmid:21751240
Trapani L et al. 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. 2012 J. Cell. Biochem. pmid:22274883
García-Pelayo MC et al. Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. 2003 J. Cell. Biochem. pmid:14523992
Viereck V et al. Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. 2005 J. Cell. Biochem. pmid:16152630
Kitten GT and Nigg EA The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. 1991 J. Cell Biol. pmid:2007618
Beck LA et al. Isoprenylation is required for the processing of the lamin A precursor. 1990 J. Cell Biol. pmid:2335559
Liscum L et al. The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts. 1989 J. Cell Biol. pmid:2715172
Beck LA et al. Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei. 1988 J. Cell Biol. pmid:3170631
Hashimoto A et al. P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. 2016 J. Cell Biol. pmid:27044891
Fenton RG et al. Regulation of intracellular actin polymerization by prenylated cellular proteins. 1992 J. Cell Biol. pmid:1560030
Schmidt RA et al. A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells. 1982 J. Cell Biol. pmid:7142283
Hampton RY and Rine J Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. 1994 J. Cell Biol. pmid:8163547
Firmbach-Kraft I and Stick R The role of CaaX-dependent modifications in membrane association of Xenopus nuclear lamin B3 during meiosis and the fate of B3 in transfected mitotic cells. 1993 J. Cell Biol. pmid:8276888
Coppens I et al. Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. 2000 J. Cell Biol. pmid:10747095
Song JX et al. Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. 2011 J. Cardiovasc. Pharmacol. pmid:21052011
Gómez-Hernández A et al. Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. 2006 J. Cardiovasc. Pharmacol. pmid:16424787
Capuzzi DM and Cevallos WH Inhibition of hepatic cholesterol and triglyceride synthesis by guanabenz acetate. 1984 J. Cardiovasc. Pharmacol. pmid:6084138
Garnett DJ Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer. 2016 J. Cancer Res. Clin. Oncol. pmid:26573510
Woo JT et al. Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. 2000 J. Bone Miner. Res. pmid:10780857
Parhami F et al. Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. 2002 J. Bone Miner. Res. pmid:12412807
van beek E et al. The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates. 1999 J. Bone Miner. Res. pmid:10320520
Luckman SP et al. JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). 2005 J. Bone Miner. Res. pmid:16050006
Luckman SP et al. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. 1998 J. Bone Miner. Res. pmid:9556058
Catherwood BD et al. Growth of rat osteoblast-like cells in a lipid-enriched culture medium and regulation of function by parathyroid hormone and 1,25-dihydroxyvitamin D. 1988 J. Bone Miner. Res. pmid:3223357
Thompson K and Rogers MJ Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. 2004 J. Bone Miner. Res. pmid:14969398
Liu J et al. Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. 2013 J. Biotechnol. pmid:24161921
Dubey VS et al. An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants. 2003 J. Biosci. pmid:14517367
Roitelman J and Simoni RD Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. 1992 J. Biol. Chem. pmid:1460026
Wang Y et al. Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1990 J. Biol. Chem. pmid:2123872
Chang TY and Limanek JS Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells. 1980 J. Biol. Chem. pmid:6105157
Marinier E et al. Contribution of the shunt pathway of mevalonate metabolism to the regulation of cholesterol synthesis in rat liver. 1987 J. Biol. Chem. pmid:3680279
Watson JA et al. Isoprenoid synthesis in isolated embryonic Drosophila cells. Sterol-independent regulatory signal molecule is distal to isopentenyl 1-pyrophosphates. 1985 J. Biol. Chem. pmid:4055772
Ramm PJ and Caspi E The stereochemistry of tritium at carbon atoms 1, 7, and 15 in cholesterol derived from (3R,2R)-(2-3H)-mevalonic acid. 1969 J. Biol. Chem. pmid:5350956
Potter D and Miziorko HM Identification of catalytic residues in human mevalonate kinase. 1997 J. Biol. Chem. pmid:9325256