| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu H et al. | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16774905 |
| Haratake A et al. | Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | 2006 | Skin Pharmacol Physiol | pmid:16778459 |
| Beckman JA and Creager MA | The nonlipid effects of statins on endothelial function. | 2006 | Trends Cardiovasc. Med. | pmid:16781949 |
| Parsons RB et al. | Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. | 2006 | Biochem. J. | pmid:16803455 |
| Muñoz-GarcÃa B et al. | Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. | 2006 | Stroke | pmid:16809572 |
| Zahiri HS et al. | Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. | 2006 | Metab. Eng. | pmid:16815062 |
| pmid:16817021 | ||||
| pmid:16828882 | ||||
| pmid:16831938 | ||||
| Dincer M et al. | Statins may decrease skeletal-related events in breast cancer patients with bone metastases. | 2006 | Med. Hypotheses | pmid:16844315 |
| Dimitroulakos J et al. | Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. | 2006 | Clin. Cancer Res. | pmid:16857822 |
| Yi P et al. | The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | 2006 | Science | pmid:16857902 |
| Kinderlerer AR et al. | Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16859540 |
| Saini GS et al. | Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | 2006 | J. Lipid Res. | pmid:16861623 |
| Ohm TG and Meske V | Cholesterol, statins and tau. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866917 |
| Crisby M | The role of pleiotropic effects of statins in dementia. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866920 |
| Macreadie IG et al. | Growth inhibition of Candida species and Aspergillus fumigatus by statins. | 2006 | FEMS Microbiol. Lett. | pmid:16907733 |
| van Hellemond JJ and Tielens AG | Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. | 2006 | FEBS Lett. | pmid:16920110 |
| Ural AU et al. | In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. | 2006 | Breast Cancer Res. | pmid:16925824 |
| pmid:1695391 | ||||
| Kwintkiewicz J et al. | Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. | 2006 | Fertil. Steril. | pmid:16963032 |
| pmid:16973124 | ||||
| Pozo M et al. | Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. | 2006 | Eur. J. Pharmacol. | pmid:16973154 |
| Edwards PA | The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes. | 1975 | Arch. Biochem. Biophys. | pmid:169744 |
| Pappu AS et al. | Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. | 2006 | J. Lipid Res. | pmid:16983147 |
| pmid:16996129 | ||||
| März P et al. | Statins induce differentiation and cell death in neurons and astroglia. | 2007 | Glia | pmid:16998865 |
| pmid:17002894 | ||||
| Kuzina V et al. | Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. | 2006 | Arch. Microbiol. | pmid:17009023 |
| pmid:17046548 | ||||
| pmid:17046792 | ||||
| Kosztáczky B et al. | Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. | 2006 | Neuropeptides | pmid:17049599 |
| Kuwana M | Potential benefit of statins for vascular disease in systemic sclerosis. | 2006 | Curr Opin Rheumatol | pmid:17053504 |
| Sjögren B et al. | Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | 2006 | Eur. J. Pharmacol. | pmid:17064686 |
| Ben-Tal Cohen E et al. | Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. | 2007 | Biochem. Pharmacol. | pmid:17070781 |
| Mandey SH et al. | A role for geranylgeranylation in interleukin-1beta secretion. | 2006 | Arthritis Rheum. | pmid:17075828 |
| Nakata S et al. | Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17082483 |
| Pandak WM et al. | Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis. | 1990 | J. Lipid Res. | pmid:1708805 |
| Issat T et al. | Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. | 2006 | Oncol. Rep. | pmid:17089049 |
| Shang F et al. | Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094942 |
| Brinkkoetter PT et al. | Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. | 2006 | Clin. Exp. Immunol. | pmid:17100774 |
| Yoon SH et al. | Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. | 2007 | Appl. Microbiol. Biotechnol. | pmid:17115209 |
| Chakrabarti R and Engleman EG | Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. | 1991 | J. Biol. Chem. | pmid:1712015 |
| pmid:17150261 | ||||
| Saijonmaa O et al. | Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17158648 |
| Enfissi EM et al. | Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. | 2005 | Plant Biotechnol. J. | pmid:17168896 |
| pmid:17178381 | ||||
| Tanaka T et al. | Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. | 2007 | Int. Immunol. | pmid:17182966 |
| Dietzen DJ et al. | Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17185615 |
| Alegret M and Silvestre JS | Pleiotropic effects of statins and related pharmacological experimental approaches. | 2006 | Methods Find Exp Clin Pharmacol | pmid:17200729 |
| Igarashi J et al. | Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | 2007 | Br. J. Pharmacol. | pmid:17220911 |
| pmid:17233845 | ||||
| pmid:17239639 | ||||
| Kuroda M et al. | Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. | 2007 | J. Antimicrob. Chemother. | pmid:17242033 |
| pmid:17250803 | ||||
| pmid:17251484 | ||||
| Honda A et al. | Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. | 2007 | J. Lipid Res. | pmid:17272831 |
| D'Amico L et al. | A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. | 2007 | Curr. Biol. | pmid:17276918 |
| pmid:17277961 | ||||
| Ferri N et al. | Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17303772 |
| pmid:17303974 | ||||
| pmid:17305502 | ||||
| Inglese J et al. | Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. | 1992 | J. Biol. Chem. | pmid:1730692 |
| Nakajima H et al. | Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. | 2007 | Cancer Lett. | pmid:17316980 |
| Habib A et al. | Modulation of COX-2 expression by statins in human monocytic cells. | 2007 | FASEB J. | pmid:17317725 |
| Riganti C et al. | Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322126 |
| Journe F et al. | Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | 2008 | Breast Cancer Res. Treat. | pmid:17333335 |
| Desai B et al. | Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. | 2007 | Mol. Cancer | pmid:17343740 |
| pmid:17361977 | ||||
| pmid:17390058 | ||||
| pmid:17393658 | ||||
| Sgraja T et al. | Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. | 2007 | BMC Struct. Biol. | pmid:17397541 |
| Andreassi JL et al. | Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. | 2007 | Protein Sci. | pmid:17400916 |
| Kinsella BT and Maltese WA | rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids. | 1992 | J. Biol. Chem. | pmid:1740442 |
| Chun KT and Simoni RD | The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1992 | J. Biol. Chem. | pmid:1740463 |
| Wong J et al. | Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | 2007 | Lipids Health Dis | pmid:17408498 |
| Maurer-Stroh S et al. | Towards complete sets of farnesylated and geranylgeranylated proteins. | 2007 | PLoS Comput. Biol. | pmid:17411337 |
| Roelofs AJ et al. | Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17412884 |
| Takeda I et al. | Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. | 2007 | Cancer Sci. | pmid:17428261 |
| pmid:17433859 | ||||
| pmid:17438551 | ||||
| Hargreaves IP | Coenzyme Q10 in phenylketonuria and mevalonic aciduria. | 2007 | Mitochondrion | pmid:17442628 |
| Hunter WN | The non-mevalonate pathway of isoprenoid precursor biosynthesis. | 2007 | J. Biol. Chem. | pmid:17442674 |
| Lee MH et al. | Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. | 2007 | Stem Cells | pmid:17464088 |
| Matsunaga S et al. | Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. | 2007 Mar-Apr | Anticancer Res. | pmid:17465222 |
| pmid:17467633 | ||||
| Buhaescu I and Izzedine H | Mevalonate pathway: a review of clinical and therapeutical implications. | 2007 | Clin. Biochem. | pmid:17467679 |
| Parsons RB et al. | A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. | 2007 | J. Neurochem. | pmid:17472704 |
| pmid:17474781 | ||||
| Takahashi HK et al. | Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. | 2007 | Clin. Immunol. | pmid:17482516 |
| pmid:17482888 | ||||
| pmid:1748720 | ||||
| Henriksson LM et al. | Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. | 2007 | J. Biol. Chem. | pmid:17491006 |
| Yoon SH et al. | Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. | 2007 May-Jun | Biotechnol. Prog. | pmid:17500531 |
| pmid:17516328 | ||||
| Li M et al. | Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17545489 |
| Kwong LK et al. | Intestinal and hepatic cholesterogenesis in hypercholesterolemic dyslipidemia of experimental diabetes in dogs. | 1991 | Diabetes | pmid:1756903 |
| Lopes AA et al. | Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). | 2007 | Phytochemistry | pmid:17574633 |
| Kutrzeba L et al. | Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. | 2007 | Phytochemistry | pmid:17574635 |
| Hao M et al. | Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. | 2007 | Diabetes | pmid:17575085 |