Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
Meigs TE et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. 1996 J. Biol. Chem. pmid:8626470
Hughes PE and Tove SB Synthesis of alpha-tocopherolquinone by the rat and its reduction by mitochondria. 1980 J. Biol. Chem. pmid:7391070
Roitelman J and Simoni RD Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. 1992 J. Biol. Chem. pmid:1460026
Kim CM et al. cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function. 1992 J. Biol. Chem. pmid:1429658
Overmeyer JH and Maltese WA Isoprenoid requirement for intracellular transport and processing of murine leukemia virus envelope protein. 1992 J. Biol. Chem. pmid:1429616
Gardner RG and Hampton RY A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. 1999 J. Biol. Chem. pmid:10531376
Kinsella BT and Maltese WA rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids. 1992 J. Biol. Chem. pmid:1740442
Tabas I et al. Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate. 1988 J. Biol. Chem. pmid:3422077
Saucier SE et al. Accumulation of regulatory oxysterols, 32-oxolanosterol and 32-hydroxylanosterol in mevalonate-treated cell cultures. 1987 J. Biol. Chem. pmid:3654653
Inglese J et al. Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 1992 J. Biol. Chem. pmid:1730692
Löw P et al. The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues. 1991 J. Biol. Chem. pmid:1918042
Murthy S et al. Regulation of fatty acid synthesis by farnesyl pyrophosphate. 2005 J. Biol. Chem. pmid:16221687
Saucier SE et al. Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts. 1985 J. Biol. Chem. pmid:4055791
Chun KT et al. The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum. 1990 J. Biol. Chem. pmid:2254343
Maltese WA and Erdman RA Characterization of isoprenoid involved in the post-translational modification of mammalian cell proteins. 1989 J. Biol. Chem. pmid:2808372
Wang Y et al. Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1990 J. Biol. Chem. pmid:2123872
Gonzalez-Pacanowska D et al. Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation. 1988 J. Biol. Chem. pmid:3335546
Maltese WA et al. Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid. 1990 J. Biol. Chem. pmid:2105317
Farnsworth CC et al. Human lamin B contains a farnesylated cysteine residue. 1989 J. Biol. Chem. pmid:2684976
Kandutsch AA and Chen HW Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition. 1977 J. Biol. Chem. pmid:833134
Wiley MH et al. The quantitative role of the kidneys in the in vivo metabolism of mevalonate. 1977 J. Biol. Chem. pmid:833143
Ravid T et al. Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells. 1999 J. Biol. Chem. pmid:10506194
Bi X et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. 2004 J. Biol. Chem. pmid:15364922
Sagami H and Lennarz WJ Glycoprotein synthesis in Drosophila Kc cells. Biosynthesis of dolichol-linked saccharides. 1987 J. Biol. Chem. pmid:3680215
Wolda SL and Glomset JA Evidence for modification of lamin B by a product of mevalonic acid. 1988 J. Biol. Chem. pmid:3283116
Zamir LO and Devor KA Kinetic pulse-labeling study of Fusarium culmorum. Biosynthetic intermediates and dead-end metabolites. 1987 J. Biol. Chem. pmid:3680199
Cornforth JW et al. Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate. 1966 J. Biol. Chem. pmid:4288360
Sherban DG et al. Rat liver 3-hydroxy-3-methylglutaryl-CoA reductase. Catalysis of the reverse reaction and two half-reactions. 1985 J. Biol. Chem. pmid:2413027
Dorsey JK and Porter JW The inhibition of mevalonic kinase by geranyl and farnesyl pyrophosphates. 1968 J. Biol. Chem. pmid:4300840
Lakshmanan MR and Veech RL Measurement of rate of rat liver sterol synthesis in vivo using tritiated water. 1977 J. Biol. Chem. pmid:873910
Weinstock SB et al. The shunt pathway of mevalonate metabolism in the isolated perfused rat liver. 1984 J. Biol. Chem. pmid:6430893
Fogelman AM et al. Metabolism of mevalonate in rats and man not leading to sterols. 1975 J. Biol. Chem. pmid:1112830
Kopito RR et al. The shunt pathway of mevalonate metabolism in the isolated perfused rat kidney. 1984 J. Biol. Chem. pmid:6706942
Fliesler SJ and Schroepfer GJ Metabolism of mevalonic acid in cell-free homogenates of bovine retinas. Formation of novel isoprenoid acids. 1983 J. Biol. Chem. pmid:6654904
Cohen DC et al. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells. Separate sterol and non-sterol components. 1982 J. Biol. Chem. pmid:7107647
Wong TK and Lennarz WJ The site of biosynthesis and intracellular deposition of dolichol in rat liver. 1982 J. Biol. Chem. pmid:7076684
Reszka AA et al. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. 1999 J. Biol. Chem. pmid:10574973
Chang TY and Limanek JS Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells. 1980 J. Biol. Chem. pmid:6105157
Cabrera JA et al. Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability. 1986 J. Biol. Chem. pmid:3633268
Gold PH and Olson RE Studies on coenzyme Q. The biosynthesis of coenzyme Q9 in rat tissue slices. 1966 J. Biol. Chem. pmid:5919683
Busch SJ et al. Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CoA reductase gene expression in a human hepatoma cell line, HepG2. 1990 J. Biol. Chem. pmid:2176219
Marinier E et al. Contribution of the shunt pathway of mevalonate metabolism to the regulation of cholesterol synthesis in rat liver. 1987 J. Biol. Chem. pmid:3680279
Edmond J Ketone bodies as precursors of sterols and fatty acids in the developing rat. 1974 J. Biol. Chem. pmid:4809632
Edmond J and Popják G Transfer of carbon atoms from mevalonate to n-fatty acids. 1974 J. Biol. Chem. pmid:4809631
Jones TL and Spiegel AM Isoprenylation of an inhibitory G protein alpha subunit occurs only upon mutagenesis of the carboxyl terminus. 1990 J. Biol. Chem. pmid:2123186
Maltese WA and Aprille JR Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells. 1985 J. Biol. Chem. pmid:3850088
Larson-Casey JL et al. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. 2014 J. Biol. Chem. pmid:25378391
Pentchev PG et al. The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. 1986 J. Biol. Chem. pmid:3949747
Watson JA et al. Isoprenoid synthesis in isolated embryonic Drosophila cells. Sterol-independent regulatory signal molecule is distal to isopentenyl 1-pyrophosphates. 1985 J. Biol. Chem. pmid:4055772
Shefer S et al. Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply. 1991 J. Biol. Chem. pmid:1993648
Scallen TJ et al. Isolation and characterization of C-4 methyl intermediates in cholesterol biosynthesis after treatment of rat liver in vitro with cholestan-3 beta, 5 alpha,6 beta-triol. 1971 J. Biol. Chem. pmid:5574391
Shapiro DJ and Rodwell VW Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis. 1971 J. Biol. Chem. pmid:5574396
Malhotra HC and Nes WR The conversion of mevalonate to 24-methylenecycloartanol by a cell-free enzyme preparation from nonphotosynthetic tissue. 1972 J. Biol. Chem. pmid:4651646
Skorupinska-Tudek K et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. 2008 J. Biol. Chem. pmid:18502754
Van Aller RT et al. The mechanism of introduction of alkyl groups at carbon 24 of sterols. 3. The second one-carbon transfer and reduction. 1969 J. Biol. Chem. pmid:5361547
Ortiz JA et al. Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate. 1994 J. Biol. Chem. pmid:7961793
Nightingale MS et al. Testicular sterols. VI. Incorporation of mevalonate into squalene and sterols by cell-free preparations of testicular tissue. 1967 J. Biol. Chem. pmid:4290213
Clarke CF et al. Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver. 1985 J. Biol. Chem. pmid:3850901
Khosravi-Far R et al. Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct. 1992 J. Biol. Chem. pmid:1332953
Zamir LO et al. Structure determination and biosynthesis of a novel metabolite of Fusarium culmorum, apotrichodiol. 1987 J. Biol. Chem. pmid:3680200
Mayer RJ et al. Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells. 1991 J. Biol. Chem. pmid:1657912
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN THE RABBIT AND GUINEA PIG. 1964 J. Biol. Chem. pmid:14213342
Niknejad N et al. Activation of the integrated stress response regulates lovastatin-induced apoptosis. 2007 J. Biol. Chem. pmid:17699156
Ostrowski SM et al. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. 2007 J. Biol. Chem. pmid:17646164
Brady PS et al. The tracing of the pathway of mevalonate's metabolism to other than sterols. 1982 J. Biol. Chem. pmid:6809755
Ramm PJ and Caspi E The stereochemistry of tritium at carbon atoms 1, 7, and 15 in cholesterol derived from (3R,2R)-(2-3H)-mevalonic acid. 1969 J. Biol. Chem. pmid:5350956
Mulheirn LJ and Caspi E Mechanism of squalene cyclization. The biosynthesis of fusidic acid. 1971 J. Biol. Chem. pmid:5553407
Sinensky M et al. Analysis of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in a somatic cell mutant auxotrophic for mevalonate. 1982 J. Biol. Chem. pmid:7085625
Blader IJ et al. Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. 2001 J. Biol. Chem. pmid:11294868
Ogilvie JW and Kaplan BH The inhibition of sterol biosynthesis in rat liver homogenates by bile. 1966 J. Biol. Chem. pmid:5926178
Edwards PA et al. Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo. 1977 J. Biol. Chem. pmid:14128
Chesterton CJ Distribution of cholesterol precursors and other lipids among rat liver intracellular structures. 1968 J. Biol. Chem. pmid:5646164
Brown MS et al. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. 1974 J. Biol. Chem. pmid:4359767
BRODIE JD et al. ENZYME-BOUND INTERMEDIATES IN THE BIOSYNTHESIS OF MEVALONIC AND PALMITIC AICDS. 1964 J. Biol. Chem. pmid:14189864
Tilvis R et al. Metabolism of squalene in human fat cells. Demonstration of a two-pool system. 1982 J. Biol. Chem. pmid:7107606
Sapkota GP et al. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. 2001 J. Biol. Chem. pmid:11297520
Nair AK and Menon KM Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. 2005 J. Biol. Chem. pmid:16263716
Lee CS and O'Sullivan WJ The interaction of phosphorothioate analogues of ATP with phosphomevalonate kinase. Kinetic and 31P NMR studies. 1985 J. Biol. Chem. pmid:2997186
Fairbanks KP et al. Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor. 1984 J. Biol. Chem. pmid:6693424
Panini SR et al. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis. Possible mediators of low density lipoprotein action. 1984 J. Biol. Chem. pmid:6736025
Hinson DD et al. Identification of an active site alanine in mevalonate kinase through characterization of a novel mutation in mevalonate kinase deficiency. 1997 J. Biol. Chem. pmid:9334262
Potter D and Miziorko HM Identification of catalytic residues in human mevalonate kinase. 1997 J. Biol. Chem. pmid:9325256
Katsuki H and Bloch K Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. 1967 J. Biol. Chem. pmid:6016607
Edwards PA Effect of adrenalectomy and hypophysectomy on the circadian rhythm of -hydroxy- -methylglutaryl coenzyme A reductase activity in rat liver. 1973 J. Biol. Chem. pmid:4697401
Pertusa M et al. Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. 2007 J. Biol. Chem. pmid:17652086
Siddals KW et al. Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. 2004 J. Biol. Chem. pmid:15247258
Carlberg M et al. Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. 1996 J. Biol. Chem. pmid:8663239
Drevon CA et al. Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. 1980 J. Biol. Chem. pmid:7410416
Beytia E et al. Purification and mechanism of action of hog liver mevalonic kinase. 1970 J. Biol. Chem. pmid:5469176
Nambudiri AM et al. The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts. 1980 J. Biol. Chem. pmid:7380842
Jakoi L and Quarfordt SH Alterations of rat hepatic cholesterogenesis by heterologous lipoproteins. 1977 J. Biol. Chem. pmid:197106
Chun KT and Simoni RD The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1992 J. Biol. Chem. pmid:1740463
Correll CC et al. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1994 J. Biol. Chem. pmid:8021239
Thompson SL et al. Cholesterol synthesis in rat liver peroxisomes. Conversion of mevalonic acid to cholesterol. 1987 J. Biol. Chem. pmid:3693362
Faust JR et al. Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts. 1980 J. Biol. Chem. pmid:7391033
Hiser L et al. ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. 1994 J. Biol. Chem. pmid:7989303
Brown MS and Goldstein JL Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. 1974 J. Biol. Chem. pmid:4436312
Laufs U and Liao JK Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. 1998 J. Biol. Chem. pmid:9727051
Hemmerlin A et al. Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. 2003 J. Biol. Chem. pmid:12736259
Swiezewska E et al. Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves. 1993 J. Biol. Chem. pmid:8419349