Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Alvarez De Sotomayor M et al. Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. 2000 Br. J. Pharmacol. pmid:11082126
Gregory DH et al. Mechanism of secretion of biliary lipids. I. Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol. 1975 J. Clin. Invest. pmid:1109174
Palinski W Immunomodulation: a new role for statins? 2000 Nat. Med. pmid:11100105
Jones JP et al. Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. 1975 J. Neurochem. pmid:1110355
pmid:11108295
pmid:11111075
Hahn FM et al. 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. 2001 J. Bacteriol. pmid:11114895
Daugherty M et al. Archaeal shikimate kinase, a new member of the GHMP-kinase family. 2001 J. Bacteriol. pmid:11114929
Campos N et al. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. 2001 Biochem. J. pmid:11115399
Chen H et al. Fluvastatin upregulates inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells. 2000 Hypertension pmid:11116101
Asada Y et al. Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway. 2000 Phytochemistry pmid:11117880
Fogelman AM et al. Metabolism of mevalonate in rats and man not leading to sterols. 1975 J. Biol. Chem. pmid:1112830
pmid:11133248
Ginger ML et al. The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana. 2001 J. Biol. Chem. pmid:11148203
Laffitte BA et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11149950
pmid:11150405
Luo JD et al. Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes. 2001 Br. J. Pharmacol. pmid:11156573
Kaneda K et al. An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11158573
Dunford JE et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. 2001 J. Pharmacol. Exp. Ther. pmid:11160603
Reszka AA et al. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. 2001 Mol. Pharmacol. pmid:11160853
Alvarez de Sotomayor M and Andriantsitohaina R Simvastatin and Ca(2+) signaling in endothelial cells: involvement of rho protein. 2001 Biochem. Biophys. Res. Commun. pmid:11162544
Kritchevsky D et al. Experimental atherosclerosis in rabbits fed cholesterol-free diets. 4. Investigation into the source of cholesteremia. 1975 Exp. Mol. Pathol. pmid:1116563
Fogelman AM et al. Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. 1975 J. Biol. Chem. pmid:1116997
pmid:11170564
Eisenreich W et al. Deoxyxylulose phosphate pathway to terpenoids. 2001 Trends Plant Sci. pmid:11173292
García-Román N et al. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. 2001 Mol. Cell. Neurosci. pmid:11178870
Chiang JY et al. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). 2001 Gene pmid:11179691
Gibbons GF and Mitropoulos KA Effect of trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride and carbon monoxide on hepatic cholesterol biosynthesis from 4,4,-dimethyl sterols in vitro. 1975 Biochim. Biophys. Acta pmid:1120146
Dimitroulakos J et al. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. 2001 Clin. Cancer Res. pmid:11205904
pmid:11219805
pmid:11222952
Kovanen PT et al. Regulation of cholesterol synthesis and storage in fat cells. 1975 J. Lipid Res. pmid:1127358
Altincicek B et al. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. 2001 J. Bacteriol. pmid:11274098
pmid:11275002
pmid:11281132
Archelas A and Furstoss R Synthetic applications of epoxide hydrolases. 2001 Curr Opin Chem Biol pmid:11282336
Jenkins DJ et al. Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. 2001 Metab. Clin. Exp. pmid:11288049
Schwender J et al. Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. 2001 Planta pmid:11289606
Zhang Z et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. 2001 J. Lipid Res. pmid:11290837
Blader IJ et al. Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. 2001 J. Biol. Chem. pmid:11294868
Sapkota GP et al. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. 2001 J. Biol. Chem. pmid:11297520
Sharkey TD et al. Isoprene increases thermotolerance of fosmidomycin-fed leaves. 2001 Plant Physiol. pmid:11299379
pmid:11305090
Jagdev SP et al. The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. 2001 Br. J. Cancer pmid:11308265
Houten SM et al. Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. 2001 Eur. J. Hum. Genet. pmid:11313768
Skaletz-Rorowski A et al. Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. 2001 Eur. J. Cell Biol. pmid:11322384
Takemoto M et al. NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. 2001 Br. J. Pharmacol. pmid:11325797
pmid:11336263
Martínez-González J et al. 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11348878
O'Neill FH et al. Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11348882