Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Redding-Johanson AM et al. Targeted proteomics for metabolic pathway optimization: application to terpene production. 2011 Metab. Eng. pmid:21215324
Huang SH et al. Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. 2011 PLoS ONE pmid:21966365
Singh NK et al. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. 2011 Blood pmid:21841162
Ma SM et al. Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases. 2011 Metab. Eng. pmid:21810477
Yu F et al. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. 2011 Cell. Mol. Life Sci. pmid:20730551
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Tijerino A et al. Overexpression of the Trichoderma brevicompactum tri5 gene: effect on the expression of the trichodermin biosynthetic genes and on tomato seedlings. 2011 Toxins (Basel) pmid:22069764
Wang H et al. Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. 2011 J. Immunol. pmid:22013129
Ali OF et al. Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. 2011 Respir. Res. pmid:21999923
Bergman P et al. Studies on the antibacterial effects of statins--in vitro and in vivo. 2011 PLoS ONE pmid:21912631
Emma F et al. Renal mitochondrial cytopathies. 2011 Int J Nephrol pmid:21811680
Ageenko NV et al. Expression of Pigment Cell-Specific Genes in the Ontogenesis of the Sea Urchin Strongylocentrotus intermedius. 2011 Evid Based Complement Alternat Med pmid:21804858
Cheng G et al. Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. 2011 Cancer Biol. Ther. pmid:21799303
Jeon JG et al. Natural products in caries research: current (limited) knowledge, challenges and future perspective. 2011 Caries Res. pmid:21576957
Scheller EL et al. Bisphosphonates inhibit expression of p63 by oral keratinocytes. 2011 J. Dent. Res. pmid:21551338
Kishi T Mevalonate pathway is a novel target for hypertension. 2011 Circ. J. pmid:21532185
Sakamoto K et al. Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. 2011 BMC Musculoskelet Disord pmid:21524281
Han J et al. Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. 2011 Circ. J. pmid:21467659
Song JX et al. Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. 2011 J. Cardiovasc. Pharmacol. pmid:21052011
Siddals KW et al. Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. 2011 J. Biol. Chem. pmid:21454560
Brock NL et al. Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. 2011 Chembiochem pmid:21990128
Mongélard G et al. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. 2011 Plant Cell Environ. pmid:21443577
Zhang B et al. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. 2011 Biochemistry pmid:21438569
Kim RH et al. Bisphosphonates induce senescence in normal human oral keratinocytes. 2011 J. Dent. Res. pmid:21427353
Kyathanahalli CN and Kowluru A A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. 2011 Biochem. Pharmacol. pmid:21406184
Zhao Y et al. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. 2011 J. Invest. Dermatol. pmid:21390048
Blankier S et al. The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. 2011 Clin. Exp. Immunol. pmid:21361911
Ghavami S et al. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. 2011 PLoS ONE pmid:21304979
Ignea C et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. 2011 Microb. Cell Fact. pmid:21276210
Cluis CP et al. Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). 2011 Metab. Eng. pmid:21986057
Kim KH et al. Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. 2011 Drug Metab. Dispos. pmid:20962060
Miziorko HM Enzymes of the mevalonate pathway of isoprenoid biosynthesis. 2011 Arch. Biochem. Biophys. pmid:20932952
Relja B et al. Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. 2011 Int. J. Oncol. pmid:21206971
Li YY et al. Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. 2011 Anticancer Drugs pmid:20926944
Liu Q et al. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. 2011 PLoS ONE pmid:21858047
Kimachi K et al. Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. 2011 Naunyn Schmiedebergs Arch. Pharmacol. pmid:21225243
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Jouneau S et al. Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. 2011 PLoS ONE pmid:21826199
Lin Y et al. Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. 2011 Evid Based Complement Alternat Med pmid:19228775
Sakai H and Heike T [Hyperimmunoglobulinemia D and periodic fever syndrome]. 2011 Nihon Rinsho Meneki Gakkai Kaishi pmid:22041426
Zhong WB et al. Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. 2011 Biochem. Pharmacol. pmid:21907187
Zeki AA et al. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. 2011 Drug Metab Lett pmid:21198438
Llacuna L et al. Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. 2011 J. Hepatol. pmid:21145825
Hamada M et al. Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions. 2011 Thromb. Haemost. pmid:21136018
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Hao Q et al. Synthesis and anti-hypercholesterolemic evaluations of calcium salts of 4-substituted quinoline-based mevalonic acid. 2011 Chem Biol Drug Des pmid:21791012
Esemuede N et al. Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. 2011 J. Surg. Res. pmid:20338582
Soto G et al. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. 2011 J. Exp. Bot. pmid:21908473
Wong DH et al. Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. 2011 Fertil. Steril. pmid:21907337
Duke SO and Dayan FE Modes of action of microbially-produced phytotoxins. 2011 Toxins (Basel) pmid:22069756
Kindt E et al. The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma. 2011 Biomed. Chromatogr. pmid:21110384
Banfi C et al. Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. 2011 J. Thromb. Haemost. pmid:21605334
Musso A et al. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. 2011 Haematologica pmid:20884711
Jang HJ et al. Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. 2011 Microb. Cell Fact. pmid:21801353
Schaafsma D et al. Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. 2011 Respir. Res. pmid:21864337
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959
Barta ML et al. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. 2011 J. Biol. Chem. pmid:21561869
Kaneko M et al. Effect of farnesol on mevalonate pathway of Staphylococcus aureus. 2011 J. Antibiot. pmid:21772307
Yanae M et al. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. 2011 J. Exp. Clin. Cancer Res. pmid:21831290
Maki KC et al. Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. 2010 Nov-Dec J Clin Lipidol pmid:21122701
Camps D [Controversies regarding the use of statins in the acute coronary syndrome]. 2010 Aug-Sep Med Intensiva pmid:20538377
Omar SH Oleuropein in olive and its pharmacological effects. 2010 Apr-Jun Sci Pharm pmid:21179340
Wani TA et al. The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population. 2010 AAPS PharmSciTech pmid:20300897
Björkhem-Bergman L et al. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. 2010 Anticancer Res. pmid:20530415
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Honour JW Steroid assays in paediatric endocrinology. 2010 J Clin Res Pediatr Endocrinol pmid:21274330
Head BP et al. Loss of caveolin-1 accelerates neurodegeneration and aging. 2010 PLoS ONE pmid:21203469
Hamdy RC Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. 2010 Drug Des Devel Ther pmid:21151620
Stapleton PA et al. Hypercholesterolemia and microvascular dysfunction: interventional strategies. 2010 J Inflamm (Lond) pmid:21087503
Martin DM et al. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. 2010 BMC Plant Biol. pmid:20964856
Snoeren TA et al. The herbivore-induced plant volatile methyl salicylate negatively affects attraction of the parasitoid Diadegma semiclausum. 2010 J. Chem. Ecol. pmid:20407809
Lefurgy ST et al. Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. 2010 J. Biol. Chem. pmid:20404339
Palozza P et al. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. 2010 Carcinogenesis pmid:20699249
Clendening JW et al. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. 2010 Blood pmid:20360469
Delang L et al. Antiviral therapy for hepatitis C virus: beyond the standard of care. 2010 Viruses pmid:21994657
Klawitter J et al. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. 2010 Breast Cancer Res. pmid:20205716
Catros V et al. [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. 2010 Med Sci (Paris) pmid:20188051
Pontillo A et al. The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. 2010 Eur. J. Hum. Genet. pmid:20179743
Yamauchi N The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. 2010 Biosci. Biotechnol. Biochem. pmid:20139592
Olson AL et al. NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. 2010 J. Am. Chem. Soc. pmid:20112895
Yang Z et al. Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. 2010 Int. J. Cancer pmid:19626588
Acquavella N et al. Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. 2010 Cytokine pmid:19932975
Kones R Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. 2010 Drug Des Devel Ther pmid:21267417
Hooff GP et al. Isoprenoids, small GTPases and Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20382260
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Singh RS et al. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. 2010 BMC Mol. Biol. pmid:21092138
Barter MJ et al. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. 2010 Ann. Rheum. Dis. pmid:20693272
Tsuchiya M et al. Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. 2010 Endocrinology pmid:20685866
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Tekpli X et al. Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. 2010 Toxicol. Appl. Pharmacol. pmid:19931295
Rico J et al. Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. 2010 Appl. Environ. Microbiol. pmid:20675444
Okamura E et al. Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20534558
Chen CC et al. Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. 2010 J. Appl. Physiol. pmid:20466804
Norman KL and Sarnow P Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. 2010 J. Virol. pmid:19846523
Kato S et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. 2010 J. Cell. Mol. Med. pmid:19432822
Jiang XS et al. Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. 2010 Mol. Cell Proteomics pmid:20305089
Schramek N et al. Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. 2010 Phytochemistry pmid:19932496
Weerasinghe S and Samantha Dassanayake R Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD). 2010 J Mol Model pmid:19653015
Boo KH et al. Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. 2010 Biosci. Biotechnol. Biochem. pmid:21071854