Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Hecht S et al. Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11752431
Han YS et al. Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. 2002 Phytochemistry pmid:11754943
Ferri N et al. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. 2001 Biochem. Pharmacol. pmid:11755117
Izumo N et al. Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. 2001 Methods Find Exp Clin Pharmacol pmid:11771853
Richard SB et al. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. 2002 J. Biol. Chem. pmid:11786530
Brämswig S et al. Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11788421
Holstein SA et al. Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. 2002 J. Biol. Chem. pmid:11788600
pmid:11794213
Hurtado-Guerrrero R et al. Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. 2002 FEBS Lett. pmid:11801242
pmid:11810250
Rohdich F et al. Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11818558
Goodman ZD and Lequire VS Transfer of esterified cholesterol from serum lipoproteins to the liver. 1975 Biochim. Biophys. Acta pmid:1182142
pmid:11829504
Thiel R and Adam KP Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. 2002 Phytochemistry pmid:11830134
Chmielewski M et al. Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. 2001 Mol. Cell. Biochem. pmid:11855739
Eisenreich W et al. Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. 2002 J. Org. Chem. pmid:11856031
pmid:11856612
Kalinowski L et al. Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. 2002 Circulation pmid:11864921
Yokoyama K et al. HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. 2002 Circulation pmid:11864926
Fu Z et al. The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. 2002 J. Biol. Chem. pmid:11877411
Blanco-Colio LM et al. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. 2002 Atherosclerosis pmid:11882313
Ledoux S et al. Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases. 2002 Circ. Res. pmid:11884371
Paris D et al. Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. 2002 Atherosclerosis pmid:11888511
Gubina E et al. CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. 2002 Blood pmid:11895788
pmid:1193282
pmid:1193283
Virtanen SS et al. Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. 2002 Cancer Res. pmid:11980672
pmid:11987326
pmid:11995814
Masferrer A et al. Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. 2002 Plant J. pmid:12000449
pmid:12002344
Okada K et al. Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. 2002 Planta pmid:12029484
pmid:12031835
Hamano Y et al. Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. 2002 Biosci. Biotechnol. Biochem. pmid:12036054
Marino M et al. Age-related changes of cholesterol and dolichol biosynthesis in rat liver. 2002 Mech. Ageing Dev. pmid:12044967
pmid:12059229
Che P et al. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. 2002 Plant Physiol. pmid:12068107
Konrad Z and Eichler J Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. 2002 Biochem. J. pmid:12069685
Dimitroulakos J et al. Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. 2002 Jul-Aug Neoplasia pmid:12082550
pmid:12091000
Sul D and Kaneshiro ES Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. 2001 Mar-Apr J. Eukaryot. Microbiol. pmid:12095106
Porter KE et al. Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. 2002 J. Vasc. Surg. pmid:12096273
Newton CJ et al. Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. 2002 J. Endocrinol. pmid:12098658
Sutherlin A et al. Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. 2002 J. Bacteriol. pmid:12107122
Kumar B et al. Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. 2002 J. Neurosci. Res. pmid:12111853
Fang TY and Baisted DJ 2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds. 1975 Biochem. J. pmid:1212194
Christ M et al. Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. 2002 Diabetes pmid:12145183
pmid:12162608
Zager RA et al. The mevalonate pathway during acute tubular injury: selected determinants and consequences. 2002 Am. J. Pathol. pmid:12163393
Li L et al. Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. 2002 Mol. Pharmacol. pmid:12181436