| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Elliott JG and Lachance PA | Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. | 1980 | J. Nutr. | pmid:7381607 |
| Yu SG et al. | Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. | 1995 | J. Nutr. | pmid:7472655 |
| Bell FP et al. | L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits. | 1992 | J. Nutr. | pmid:1552371 |
| Fillios LC et al. | Synthesis and distribution of cholesterol, and the effect of diet, at the liver endoplasmic reticula and plasma membranes from lean or obese rats. | 1969 | J. Nutr. | pmid:5784252 |
| Ukai M et al. | Cholesterol synthesis in germfree and conventional rats. | 1976 | J. Nutr. | pmid:939998 |
| Mukherjee C et al. | In vitro studies on the effect of different dietary fats and different proportions of dietary protein on the synthesis of lipids by rat arterial tissue. | 1971 | J. Nutr. | pmid:5578922 |
| Peffley DM and Gayen AK | Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. | 2003 | J. Nutr. | pmid:12514264 |
| Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
| Grossi-Paoletti E et al. | Lipids in brain tumors. | 1971 | J. Neurosurg. | pmid:4323146 |
| Kumar B et al. | Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | 2002 | J. Neurosci. Res. | pmid:12111853 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. | 1998 | J. Neurosci. Res. | pmid:9778150 |
| Braun PE et al. | Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes. | 1991 | J. Neurosci. Res. | pmid:1666129 |
| Rattan R et al. | Rho/ROCK pathway as a target of tumor therapy. | 2006 | J. Neurosci. Res. | pmid:16385577 |
| Zacco A et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. | 2003 | J. Neurosci. | pmid:14657168 |
| Tanaka T et al. | Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 2000 | J. Neurosci. | pmid:10751437 |
| Cordle A and Landreth G | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. | 2005 | J. Neurosci. | pmid:15647473 |
| Fortin DL et al. | Lipid rafts mediate the synaptic localization of alpha-synuclein. | 2004 | J. Neurosci. | pmid:15282274 |
| Schulz JG et al. | HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. | 2004 | J. Neurochem. | pmid:15030386 |
| Langan TJ and Volpe JJ | Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures. | 1987 | J. Neurochem. | pmid:3648095 |
| Jones JP et al. | Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. | 1975 | J. Neurochem. | pmid:1110355 |
| Rostas JA et al. | Selective labelling of two phases of axonal transport of cholesterol in the chick optic system. | 1979 | J. Neurochem. | pmid:86598 |
| Sliwowski JK et al. | The in vivo biosynthesis of cholesterol from (3RS,2R) [2-14C,2-3H]mevalonic acid in the brains of rats on normal and protein deficient diets. The stereochemistry of tritium atoms at C-7 and C-15. | 1977 | J. Neurochem. | pmid:874493 |
| Langan TJ and Volpe JJ | Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate. | 1987 | J. Neurochem. | pmid:3033149 |
| Menkes JH | Lipid metabolism in brain tissue explants. | 1971 | J. Neurochem. | pmid:5092865 |
| Hughes M et al. | Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. | 2010 | J. Neurochem. | pmid:20477946 |
| Chevallier F and Gautheron C | A method for the study of cholesterol biosynthesis in the central nervous system. Incorporation of [2-14C]mevalonic lactone after intraperitoneal, intracisternal and intraventricular administration in the rat. | 1969 | J. Neurochem. | pmid:5795585 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. | 1972 | J. Neurochem. | pmid:5009889 |
| Parsons RB et al. | A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. | 2007 | J. Neurochem. | pmid:17472704 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. | 1971 | J. Neurochem. | pmid:5092868 |
| Kim WY et al. | Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. | 2009 | J. Neurochem. | pmid:19209406 |
| Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
| Weiss JF et al. | Sterols with 29, 28 and 27 carbon atoms metabolically related to cholesterol, occurring in developing and mature brain. | 1968 | J. Neurochem. | pmid:5675585 |
| Schedin S et al. | Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. | 1995 | J. Neurochem. | pmid:7616223 |
| Jones JP et al. | The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats. | 1975 | J. Neurochem. | pmid:1167373 |
| Volpe JJ and Obert KA | Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin. | 1982 | J. Neurochem. | pmid:7062041 |
| Crick DC et al. | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. | 1998 | J. Neurochem. | pmid:9603204 |
| Jeng I et al. | Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A. | 1984 | J. Neurochem. | pmid:6567656 |
| Crick DC et al. | Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. | 1995 | J. Neurochem. | pmid:7643114 |
| Heacock AM et al. | Cholesterol synthesis and nerve regeneration. | 1984 | J. Neurochem. | pmid:6699648 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of (2- 14 C)mevalonic acid into 30-day-old rat brain: a period of transition. | 1972 | J. Neurochem. | pmid:5019590 |
| Surup F et al. | Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. | 2015 | J. Nat. Prod. | pmid:25871540 |
| Soliman SS et al. | Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. | 2011 | J. Nat. Prod. | pmid:22103292 |
| Itoh D et al. | Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. | 2000 | J. Nat. Prod. | pmid:10978203 |
| Itoh D et al. | Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. | 2003 | J. Nat. Prod. | pmid:12662088 |
| Baba TT et al. | Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. | 2008 | J. Muscle Res. Cell. Motil. | pmid:18792797 |
| Perttilä J et al. | OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | 2009 | J. Mol. Med. | pmid:19554302 |
| Habeos IG et al. | Simvastatin activates Keap1/Nrf2 signaling in rat liver. | 2008 | J. Mol. Med. | pmid:18787804 |
| Turunen M et al. | Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. | 2000 | J. Mol. Biol. | pmid:10731415 |
| Byres E et al. | Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. | 2007 | J. Mol. Biol. | pmid:17583736 |
| Brown GR et al. | Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8709131 |
| Cayen MN | Effect of dietary tomatine on cholesterol metabolism in the rat. | 1971 | J. Lipid Res. | pmid:4362143 |
| Douglass TS et al. | The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab. | 1981 | J. Lipid Res. | pmid:7276755 |
| Feingold KR et al. | The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. | 1981 | J. Lipid Res. | pmid:7276756 |
| Matsuoka T et al. | An ultrasensitive enzymatic method for measuring mevalonic acid in serum. | 2012 | J. Lipid Res. | pmid:22715156 |
| Doerner KC et al. | Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. | 1995 | J. Lipid Res. | pmid:7665995 |
| Cayen MN and Dvornik D | Effect of diosgenin on lipid metabolism in rats. | 1979 | J. Lipid Res. | pmid:438658 |
| Scoppola A et al. | Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry. | 1991 | J. Lipid Res. | pmid:1940620 |
| Shamburek RD et al. | Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. | 1997 | J. Lipid Res. | pmid:9458266 |
| Risé P et al. | Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. | 1997 | J. Lipid Res. | pmid:9254057 |
| Ellsworth JL et al. | Very low and low density lipoprotein synthesis and secretion by the human hepatoma cell line Hep-G2: effects of free fatty acid. | 1986 | J. Lipid Res. | pmid:3021884 |
| Honda A et al. | Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. | 2007 | J. Lipid Res. | pmid:17272831 |
| Barter PJ | Production of plasma esterified cholesterol in lean, normotriglyceridemic humans. | 1974 | J. Lipid Res. | pmid:4827913 |
| Tint GS and Salen G | Transformation of 5 alpha-cholest-7-en-3 beta-ol to cholesterol and cholestanol in cerebrotendinous xanthomatosis. | 1974 | J. Lipid Res. | pmid:4827915 |
| Lüdke SM et al. | Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2008 | J. Lipid Res. | pmid:18669481 |
| Slakey LL et al. | Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. | 1973 | J. Lipid Res. | pmid:4351784 |
| Jones MP et al. | Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat. | 1993 | J. Lipid Res. | pmid:8354954 |
| Brady PS et al. | Evidence for an underestimation of the shunt pathway of mevalonate metabolism in slices of livers and kidneys from fasted rats and rats in diabetic ketosis. | 1982 | J. Lipid Res. | pmid:6819335 |
| Field FJ et al. | Regulation of cholesterol esterification by micellar cholesterol in CaCo-2 cells. | 1987 | J. Lipid Res. | pmid:3655559 |
| Brunengraber H et al. | Urinary clearance and metabolism of mevalonate by the isolataed perfused rat kidney. | 1981 | J. Lipid Res. | pmid:7276751 |
| Kovanen PT et al. | Regulation of cholesterol synthesis and storage in fat cells. | 1975 | J. Lipid Res. | pmid:1127358 |
| Stange EF et al. | Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver. | 1981 | J. Lipid Res. | pmid:7217785 |
| Harwood HJ et al. | Measurement of human leukocyte microsomal HMG-CoA reductase activity. | 1984 | J. Lipid Res. | pmid:6491541 |
| Naoumova RP et al. | Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. | 1997 | J. Lipid Res. | pmid:9254075 |
| Linder JR and Beitz DC | Sterol synthesis and CO2 production from mevalonate in calves. | 1978 | J. Lipid Res. | pmid:712243 |
| Hong C et al. | Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. | 2011 | J. Lipid Res. | pmid:21187453 |
| Shefer S et al. | Diurnal variation of HMG CoA reductase activity in rat intestine. | 1972 | J. Lipid Res. | pmid:5075502 |
| Cenedella RJ and Fleschner CR | Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development. | 1989 | J. Lipid Res. | pmid:2794790 |
| Pappu AS et al. | Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. | 2002 | J. Lipid Res. | pmid:12364550 |
| Hulcher FH and Oleson WH | Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. | 1973 | J. Lipid Res. | pmid:4147523 |
| Nestel PJ et al. | The effect of dietary fat supplements on cholesterol metabolism in ruminants. | 1978 | J. Lipid Res. | pmid:712248 |
| Dietschy JM and Brown MS | Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis. | 1974 | J. Lipid Res. | pmid:4413018 |
| Goldfarb S and Pitot HC | Improved assay of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1971 | J. Lipid Res. | pmid:5164097 |
| Imblum RL and Rodwell VW | 3-Hydroxy-3-methylglutaryl CoA reductase and mevalonate kinase of Neurospora crassa. | 1974 | J. Lipid Res. | pmid:4363966 |
| Elmberger PG et al. | Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia. | 1991 | J. Lipid Res. | pmid:1940625 |
| Gaylor JL et al. | Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. | 1966 | J. Lipid Res. | pmid:4290536 |
| Goodwin CD and Margolis S | Improved methods for the study of hepatic HMG CoA reductase: one-step isolation of mevalonolactone and rapid preparation of endoplasmic reticulum. | 1976 | J. Lipid Res. | pmid:6605 |
| Saini GS et al. | Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | 2006 | J. Lipid Res. | pmid:16861623 |
| Hidaka Y et al. | Regulation of squalene epoxidase in HepG2 cells. | 1990 | J. Lipid Res. | pmid:1964954 |
| Popják G et al. | Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts. | 1985 | J. Lipid Res. | pmid:2411835 |
| Brady PS et al. | Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. | 1983 | J. Lipid Res. | pmid:6415196 |
| Popják G et al. | Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man. | 1979 | J. Lipid Res. | pmid:226640 |
| Tucker DE et al. | Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. | 2005 | J. Lipid Res. | pmid:16061942 |
| Pappu AS et al. | Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. | 2006 | J. Lipid Res. | pmid:16983147 |
| Cartwright IJ et al. | Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes. | 1997 | J. Lipid Res. | pmid:9101434 |
| Shechter I et al. | A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. | 1980 | J. Lipid Res. | pmid:7381322 |
| Drevon CA et al. | Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. | 1980 | J. Lipid Res. | pmid:7462802 |
| Golper TA et al. | The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat. | 1986 | J. Lipid Res. | pmid:3794548 |
| Randolph RK et al. | Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low density lipoprotein receptor pathway. | 1984 | J. Lipid Res. | pmid:6491537 |
| Pandak WM et al. | Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. | 1992 | J. Lipid Res. | pmid:1619360 |
| Field FJ and Mathur SN | Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells. | 1983 | J. Lipid Res. | pmid:6631233 |