| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ye J | Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. | 2007 | PLoS Pathog. | pmid:17784784 |
| Saijonmaa O et al. | Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17158648 |
| Hao M et al. | Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. | 2007 | Diabetes | pmid:17575085 |
| Hargreaves IP | Coenzyme Q10 in phenylketonuria and mevalonic aciduria. | 2007 | Mitochondrion | pmid:17442628 |
| Kettawan A et al. | Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. | 2007 | J Clin Biochem Nutr | pmid:18398496 |
| Muñoz-Bertomeu J et al. | Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. | 2007 | Plant Biotechnol. J. | pmid:17714440 |
| Arkwright PD et al. | Mevalonic aciduria cured by bone marrow transplantation. | 2007 | N. Engl. J. Med. | pmid:17898110 |
| Zeiser R et al. | Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. | 2007 | Blood | pmid:17827390 |
| Niknejad N et al. | Activation of the integrated stress response regulates lovastatin-induced apoptosis. | 2007 | J. Biol. Chem. | pmid:17699156 |
| Kotamraju S et al. | Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. | 2007 | Cancer Res. | pmid:17671209 |
| Ostrowski SM et al. | Statins reduce amyloid-beta production through inhibition of protein isoprenylation. | 2007 | J. Biol. Chem. | pmid:17646164 |
| Hu WL et al. | Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. | 2007 | Cytokine | pmid:18023360 |
| Neven B et al. | Allogeneic bone marrow transplantation in mevalonic aciduria. | 2007 | N. Engl. J. Med. | pmid:17596604 |
| Wong WW et al. | Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. | 2007 | Mol. Cancer Ther. | pmid:17575117 |
| Dietzen DJ et al. | Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17185615 |
| Nakata S et al. | Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17082483 |
| Loiseau L et al. | ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17698959 |
| Withers ST et al. | Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. | 2007 | Appl. Environ. Microbiol. | pmid:17693564 |
| Buhaescu I and Izzedine H | Mevalonate pathway: a review of clinical and therapeutical implications. | 2007 | Clin. Biochem. | pmid:17467679 |
| März P et al. | Statins induce differentiation and cell death in neurons and astroglia. | 2007 | Glia | pmid:16998865 |
| Pertusa M et al. | Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. | 2007 | J. Biol. Chem. | pmid:17652086 |
| Takahashi HK et al. | Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. | 2007 | Clin. Immunol. | pmid:17482516 |
| Saha RN and Pahan K | Regulation of inducible nitric oxide synthase gene in glial cells. | 2006 May-Jun | Antioxid. Redox Signal. | pmid:16771683 |
| Seong K et al. | Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. | 2006 | Fungal Genet. Biol. | pmid:16377218 |
| Haratake A et al. | Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | 2006 | Skin Pharmacol Physiol | pmid:16778459 |
| Dincer M et al. | Statins may decrease skeletal-related events in breast cancer patients with bone metastases. | 2006 | Med. Hypotheses | pmid:16844315 |
| Kwintkiewicz J et al. | Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. | 2006 | Fertil. Steril. | pmid:16963032 |
| Pozo M et al. | Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. | 2006 | Eur. J. Pharmacol. | pmid:16973154 |
| Piotrowski PC et al. | Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. | 2006 | Biol. Reprod. | pmid:16571871 |
| Sakoda K et al. | Simvastatin decreases IL-6 and IL-8 production in epithelial cells. | 2006 | J. Dent. Res. | pmid:16723648 |
| Kanellis J et al. | Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | 2006 | Immunol. Cell Biol. | pmid:16405649 |
| Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
| Hampel D et al. | Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. | 2006 | J. Agric. Food Chem. | pmid:16478276 |
| Ro DK et al. | Production of the antimalarial drug precursor artemisinic acid in engineered yeast. | 2006 | Nature | pmid:16612385 |
| Sjögren B et al. | Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | 2006 | Eur. J. Pharmacol. | pmid:17064686 |
| Ohm TG and Meske V | Cholesterol, statins and tau. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866917 |
| Crisby M | The role of pleiotropic effects of statins in dementia. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866920 |
| Chana RS and Brunskill NJ | Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | 2006 | Am. J. Nephrol. | pmid:16508249 |
| Macreadie IG et al. | Growth inhibition of Candida species and Aspergillus fumigatus by statins. | 2006 | FEMS Microbiol. Lett. | pmid:16907733 |
| Kosztáczky B et al. | Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. | 2006 | Neuropeptides | pmid:17049599 |
| Ridsdale A et al. | Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. | 2006 | Mol. Biol. Cell | pmid:16452637 |
| Gómez-Hernández A et al. | Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16424787 |
| Kinderlerer AR et al. | Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16859540 |
| Kotti TJ et al. | Brain cholesterol turnover required for geranylgeraniol production and learning in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16505352 |
| Sato M et al. | Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. | 2006 | J Oleo Sci | pmid:17693695 |
| Kuzina V et al. | Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. | 2006 | Arch. Microbiol. | pmid:17009023 |
| Li JQ et al. | Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. | 2006 | Clin. Chim. Acta | pmid:16507303 |
| Parsons RB et al. | Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. | 2006 | Biochem. J. | pmid:16803455 |
| Brinkkoetter PT et al. | Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. | 2006 | Clin. Exp. Immunol. | pmid:17100774 |
| Mandey SH et al. | A role for geranylgeranylation in interleukin-1beta secretion. | 2006 | Arthritis Rheum. | pmid:17075828 |
| Ural AU et al. | In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. | 2006 | Breast Cancer Res. | pmid:16925824 |
| van Hellemond JJ and Tielens AG | Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. | 2006 | FEBS Lett. | pmid:16920110 |
| Saini GS et al. | Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | 2006 | J. Lipid Res. | pmid:16861623 |
| Yi P et al. | The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | 2006 | Science | pmid:16857902 |
| Dimitroulakos J et al. | Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. | 2006 | Clin. Cancer Res. | pmid:16857822 |
| Xu H et al. | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16774905 |
| Kawasaki T et al. | Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. | 2006 | J. Bacteriol. | pmid:16452404 |
| Haas D and Hoffmann GF | Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. | 2006 | Orphanet J Rare Dis | pmid:16722536 |
| Solito E et al. | Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. | 2006 | FASEB J. | pmid:16720734 |
| Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
| Silvander M et al. | A new water-based topical carrier with polar skin-lipids. | 2006 | Lipids Health Dis | pmid:16672068 |
| Coward WR et al. | Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. | 2006 | J. Immunol. | pmid:16621994 |
| Neville-Webbe HL et al. | Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. | 2006 | Tumour Biol. | pmid:16582586 |
| Rattan R et al. | Rho/ROCK pathway as a target of tumor therapy. | 2006 | J. Neurosci. Res. | pmid:16385577 |
| Wang J et al. | Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. | 2006 | Biol. Pharm. Bull. | pmid:16595893 |
| Benetka W et al. | Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. | 2006 | BMC Biochem. | pmid:16507103 |
| Xu L et al. | [Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. | 2006 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:16503530 |
| Riganti C et al. | Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. | 2006 | Int. J. Cancer | pmid:16450390 |
| Ramasubbu K and Mann DL | The emerging role of statins in the treatment of heart failure. | 2006 | J. Am. Coll. Cardiol. | pmid:16412858 |
| Christensen M et al. | Simvastatin protection against acute immune-mediated glomerulonephritis in mice. | 2006 | Kidney Int. | pmid:16407885 |
| González-Fernández L et al. | Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. | 2006 | FEBS J. | pmid:16367743 |
| Zahiri HS et al. | Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. | 2006 | Metab. Eng. | pmid:16815062 |
| Pappu AS et al. | Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. | 2006 | J. Lipid Res. | pmid:16983147 |
| Yoon SH et al. | Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. | 2006 | Biotechnol. Bioeng. | pmid:16547999 |
| Nagashima T et al. | Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. | 2006 | Arthritis Rheum. | pmid:16447234 |
| Yokota K et al. | Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 2006 | J. Rheumatol. | pmid:16511915 |
| Grochowski LL et al. | Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | 2006 | J. Bacteriol. | pmid:16621811 |
| Alegret M and Silvestre JS | Pleiotropic effects of statins and related pharmacological experimental approaches. | 2006 | Methods Find Exp Clin Pharmacol | pmid:17200729 |
| Muñoz-GarcÃa B et al. | Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. | 2006 | Stroke | pmid:16809572 |
| Shang F et al. | Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094942 |
| Issat T et al. | Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. | 2006 | Oncol. Rep. | pmid:17089049 |
| Kuwana M | Potential benefit of statins for vascular disease in systemic sclerosis. | 2006 | Curr Opin Rheumatol | pmid:17053504 |
| Thompson K et al. | Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. | 2006 | Blood | pmid:16179378 |
| van Beek E et al. | Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. | 2006 | Bone | pmid:16165408 |
| Hamadmad SN et al. | Erythropoietin receptor signal transduction requires protein geranylgeranylation. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16203826 |
| Qiu Y and Li D | Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. | 2006 | Org. Lett. | pmid:16524256 |
| Qiu Y and Li D | Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. | 2006 | Biochim. Biophys. Acta | pmid:16626865 |
| Beckman JA and Creager MA | The nonlipid effects of statins on endothelial function. | 2006 | Trends Cardiovasc. Med. | pmid:16781949 |
| Caruso MG and Notarnicola M | Biochemical changes of mevalonate pathway in human colorectal cancer. | 2005 Sep-Oct | Anticancer Res. | pmid:16101154 |
| Nawarskas JJ | HMG-CoA reductase inhibitors and coenzyme Q10. | 2005 Mar-Apr | Cardiol Rev | pmid:15705257 |
| Akiyama K et al. | Antitumor effect of geranylamine derivatives on human hepatoma. | 2005 Jan-Feb | In Vivo | pmid:15796170 |
| Argmann CA et al. | Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. | 2005 | J. Biol. Chem. | pmid:15817453 |
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| Kim J et al. | 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | 2005 | J. Chem. Ecol. | pmid:16222778 |
| Duncan RE et al. | Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. | 2005 | Mol Nutr Food Res | pmid:15617098 |
| Sacher J et al. | Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15914674 |
| Wang C et al. | Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. | 2005 | Mol. Cell | pmid:15893726 |
| Mahmud T et al. | A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. | 2005 | Chembiochem | pmid:15619721 |
| Okada K and Hase T | Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. | 2005 | J. Biol. Chem. | pmid:15792953 |
| Mantha AJ et al. | Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. | 2005 | Clin. Cancer Res. | pmid:15788691 |