Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Xanthomatosis D014973 17 associated lipids
Thrombosis D013927 49 associated lipids
Refsum Disease D012035 19 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia D007938 74 associated lipids
Hypothyroidism D007037 32 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306
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Lindenthal B and von Bergmann K Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. 2000 Metab. Clin. Exp. pmid:10647065
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Keizer HG The "Mevalonate hypothesis": a cholesterol-independent alternative for the etiology of atherosclerosis. 2012 Lipids Health Dis pmid:23122424
Rauthan M and Pilon M The mevalonate pathway in C. elegans. 2011 Lipids Health Dis pmid:22204706
Chen Y et al. Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. 2015 Lipids Health Dis pmid:26493087
Ohukainen P If the wheel ain't broke, don't reinvent it. 2013 Lipids Health Dis pmid:23577775
Wong J et al. Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. 2007 Lipids Health Dis pmid:17408498
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Udagawa H et al. Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. 2008 Lipids pmid:18509689
Montero-Villegas S et al. Inhibition of Mevalonate Pathway and Synthesis of the Storage Lipids in Human Liver-Derived and Non-liver Cell Lines by Lippia alba Essential Oils. 2017 Lipids pmid:27905068
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
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Betteridge DJ et al. Compactin inhibits cholesterol synthesis in lymphocytes and intestinal mucosa from patients with familial hypercholesterolaemia. 1978 Dec 23-30 Lancet pmid:82843
Lewis LS Statins, cholesterol, and mevalonate pathways? 1996 Lancet pmid:8596303
Buchwald H Cholesterol inhibition, cancer, and chemotherapy. 1992 Lancet pmid:1349377
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Haslinger B et al. Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. 2003 Kidney Int. pmid:12753293
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Nishimura M et al. Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. 1999 Kidney Int. pmid:9987076
Scoppola A et al. Plasma mevalonate concentrations in uremic patients. 1997 Kidney Int. pmid:9067929
Choi M et al. Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. 2003 Kidney Int. pmid:12472772
Fujita T et al. Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. 2001 Jpn. J. Pharmacol. pmid:11430477
Kitahara M et al. NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. 1998 Jpn. J. Pharmacol. pmid:9681568
Nagata Y et al. Effects of simvastatin (MK-733) on branched pathway of mevalonate. 1990 Jpn. J. Pharmacol. pmid:2090840
Lazzerini PE et al. Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. 2013 Joint Bone Spine pmid:22999910
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Anouja F et al. The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins. 1997 J. Virol. pmid:9151861
Nishikawa Y et al. Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. 2011 J. Vet. Med. Sci. pmid:21187676
Porter KE et al. Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. 2002 J. Vasc. Surg. pmid:12096273
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Banfi C et al. Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. 2011 J. Thromb. Haemost. pmid:21605334
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Ding Y et al. Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. 2017 J. Steroid Biochem. Mol. Biol. pmid:27864002
Yokota K et al. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. 2006 J. Rheumatol. pmid:16511915
Elkin RG and Yan Z Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens. 1999 J. Reprod. Fertil. pmid:10615252
Leonardsen L et al. Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. 2000 J. Reprod. Fertil. pmid:10793639
Ramak P et al. Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. 2013 J. Plant Physiol. pmid:23611428
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