Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Elliott JG and Lachance PA Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. 1980 J. Nutr. pmid:7381607
Yu SG et al. Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. 1995 J. Nutr. pmid:7472655
Bell FP et al. L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits. 1992 J. Nutr. pmid:1552371
Fillios LC et al. Synthesis and distribution of cholesterol, and the effect of diet, at the liver endoplasmic reticula and plasma membranes from lean or obese rats. 1969 J. Nutr. pmid:5784252
Ukai M et al. Cholesterol synthesis in germfree and conventional rats. 1976 J. Nutr. pmid:939998
Mukherjee C et al. In vitro studies on the effect of different dietary fats and different proportions of dietary protein on the synthesis of lipids by rat arterial tissue. 1971 J. Nutr. pmid:5578922
Peffley DM and Gayen AK Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. 2003 J. Nutr. pmid:12514264
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Grossi-Paoletti E et al. Lipids in brain tumors. 1971 J. Neurosurg. pmid:4323146
Kumar B et al. Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. 2002 J. Neurosci. Res. pmid:12111853
Michikawa M and Yanagisawa K Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. 1998 J. Neurosci. Res. pmid:9778150
Braun PE et al. Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes. 1991 J. Neurosci. Res. pmid:1666129
Rattan R et al. Rho/ROCK pathway as a target of tumor therapy. 2006 J. Neurosci. Res. pmid:16385577
Zacco A et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. 2003 J. Neurosci. pmid:14657168
Tanaka T et al. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. 2000 J. Neurosci. pmid:10751437
Cordle A and Landreth G 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. 2005 J. Neurosci. pmid:15647473
Fortin DL et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. 2004 J. Neurosci. pmid:15282274
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
Langan TJ and Volpe JJ Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures. 1987 J. Neurochem. pmid:3648095
Jones JP et al. Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. 1975 J. Neurochem. pmid:1110355
Rostas JA et al. Selective labelling of two phases of axonal transport of cholesterol in the chick optic system. 1979 J. Neurochem. pmid:86598
Sliwowski JK et al. The in vivo biosynthesis of cholesterol from (3RS,2R) [2-14C,2-3H]mevalonic acid in the brains of rats on normal and protein deficient diets. The stereochemistry of tritium atoms at C-7 and C-15. 1977 J. Neurochem. pmid:874493
Langan TJ and Volpe JJ Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate. 1987 J. Neurochem. pmid:3033149
Menkes JH Lipid metabolism in brain tissue explants. 1971 J. Neurochem. pmid:5092865
Hughes M et al. Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. 2010 J. Neurochem. pmid:20477946
Chevallier F and Gautheron C A method for the study of cholesterol biosynthesis in the central nervous system. Incorporation of [2-14C]mevalonic lactone after intraperitoneal, intracisternal and intraventricular administration in the rat. 1969 J. Neurochem. pmid:5795585
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. 1972 J. Neurochem. pmid:5009889
Parsons RB et al. A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. 2007 J. Neurochem. pmid:17472704
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. 1971 J. Neurochem. pmid:5092868
Kim WY et al. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. 2009 J. Neurochem. pmid:19209406
Michikawa M and Yanagisawa K Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. 1999 J. Neurochem. pmid:10349836
Weiss JF et al. Sterols with 29, 28 and 27 carbon atoms metabolically related to cholesterol, occurring in developing and mature brain. 1968 J. Neurochem. pmid:5675585
Schedin S et al. Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. 1995 J. Neurochem. pmid:7616223
Jones JP et al. The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats. 1975 J. Neurochem. pmid:1167373
Volpe JJ and Obert KA Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin. 1982 J. Neurochem. pmid:7062041
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Jeng I et al. Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A. 1984 J. Neurochem. pmid:6567656
Crick DC et al. Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. 1995 J. Neurochem. pmid:7643114
Heacock AM et al. Cholesterol synthesis and nerve regeneration. 1984 J. Neurochem. pmid:6699648
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of (2- 14 C)mevalonic acid into 30-day-old rat brain: a period of transition. 1972 J. Neurochem. pmid:5019590
Surup F et al. Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. 2015 J. Nat. Prod. pmid:25871540
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Itoh D et al. Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. 2000 J. Nat. Prod. pmid:10978203
Itoh D et al. Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. 2003 J. Nat. Prod. pmid:12662088
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Habeos IG et al. Simvastatin activates Keap1/Nrf2 signaling in rat liver. 2008 J. Mol. Med. pmid:18787804
Turunen M et al. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. 2000 J. Mol. Biol. pmid:10731415
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Brown GR et al. Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8709131
Cayen MN Effect of dietary tomatine on cholesterol metabolism in the rat. 1971 J. Lipid Res. pmid:4362143
Douglass TS et al. The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab. 1981 J. Lipid Res. pmid:7276755
Feingold KR et al. The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. 1981 J. Lipid Res. pmid:7276756
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Doerner KC et al. Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. 1995 J. Lipid Res. pmid:7665995
Cayen MN and Dvornik D Effect of diosgenin on lipid metabolism in rats. 1979 J. Lipid Res. pmid:438658
Scoppola A et al. Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry. 1991 J. Lipid Res. pmid:1940620
Kelley MT et al. Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. 1969 J. Lipid Res. pmid:4305711
Shamburek RD et al. Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. 1997 J. Lipid Res. pmid:9458266
Rosenwald AG and Krag SS Lec9 CHO glycosylation mutants are defective in the synthesis of dolichol. 1990 J. Lipid Res. pmid:2111370
Petras SF et al. HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. 1999 J. Lipid Res. pmid:9869647
Ellsworth JL et al. Very low and low density lipoprotein synthesis and secretion by the human hepatoma cell line Hep-G2: effects of free fatty acid. 1986 J. Lipid Res. pmid:3021884
Barter PJ Production of plasma esterified cholesterol in lean, normotriglyceridemic humans. 1974 J. Lipid Res. pmid:4827913
Tint GS and Salen G Transformation of 5 alpha-cholest-7-en-3 beta-ol to cholesterol and cholestanol in cerebrotendinous xanthomatosis. 1974 J. Lipid Res. pmid:4827915
Lüdke SM et al. Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2008 J. Lipid Res. pmid:18669481
Slakey LL et al. Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. 1973 J. Lipid Res. pmid:4351784
Jones MP et al. Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat. 1993 J. Lipid Res. pmid:8354954
Brady PS et al. Evidence for an underestimation of the shunt pathway of mevalonate metabolism in slices of livers and kidneys from fasted rats and rats in diabetic ketosis. 1982 J. Lipid Res. pmid:6819335
Meyers CD et al. Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. 2003 J. Lipid Res. pmid:12923222
Brunengraber H et al. Urinary clearance and metabolism of mevalonate by the isolataed perfused rat kidney. 1981 J. Lipid Res. pmid:7276751
Kovanen PT et al. Regulation of cholesterol synthesis and storage in fat cells. 1975 J. Lipid Res. pmid:1127358
Stange EF et al. Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver. 1981 J. Lipid Res. pmid:7217785
Harwood HJ et al. Measurement of human leukocyte microsomal HMG-CoA reductase activity. 1984 J. Lipid Res. pmid:6491541
Linder JR and Beitz DC Sterol synthesis and CO2 production from mevalonate in calves. 1978 J. Lipid Res. pmid:712243
Lindenthal B et al. Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis. 1996 J. Lipid Res. pmid:8906596
Pappu AS et al. Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. 2002 J. Lipid Res. pmid:12364550
Hulcher FH and Oleson WH Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. 1973 J. Lipid Res. pmid:4147523
Johnson KA et al. In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge. 1994 J. Lipid Res. pmid:7897321
Nestel PJ et al. The effect of dietary fat supplements on cholesterol metabolism in ruminants. 1978 J. Lipid Res. pmid:712248
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN RAT AND GUINEA PIG LIVER IN VITRO. 1965 J. Lipid Res. pmid:14280469
Dietschy JM and Brown MS Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis. 1974 J. Lipid Res. pmid:4413018
Schwartz CC et al. Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. 2004 J. Lipid Res. pmid:15145983
Pandak WM et al. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. 1990 J. Lipid Res. pmid:2313206
Goldfarb S and Pitot HC Improved assay of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1971 J. Lipid Res. pmid:5164097
Imblum RL and Rodwell VW 3-Hydroxy-3-methylglutaryl CoA reductase and mevalonate kinase of Neurospora crassa. 1974 J. Lipid Res. pmid:4363966
Elmberger PG et al. Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia. 1991 J. Lipid Res. pmid:1940625
Sloviter HA et al. Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. 1970 J. Lipid Res. pmid:5418482
Goodwin CD and Margolis S Improved methods for the study of hepatic HMG CoA reductase: one-step isolation of mevalonolactone and rapid preparation of endoplasmic reticulum. 1976 J. Lipid Res. pmid:6605
Saini GS et al. Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. 2006 J. Lipid Res. pmid:16861623
Björkhem I and Akerlund JE Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in rat liver. 1988 J. Lipid Res. pmid:3367083
Popják G et al. Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man. 1979 J. Lipid Res. pmid:226640
Tucker DE et al. Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. 2005 J. Lipid Res. pmid:16061942
Pappu AS et al. Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. 2006 J. Lipid Res. pmid:16983147
Cartwright IJ et al. Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes. 1997 J. Lipid Res. pmid:9101434
Drevon CA et al. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. 1980 J. Lipid Res. pmid:7462802
Golper TA et al. The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat. 1986 J. Lipid Res. pmid:3794548
Gibson KM et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured fibroblasts from patients with mevalonate kinase deficiency: differential response to lipid supplied by fetal bovine serum in tissue culture medium. 1990 J. Lipid Res. pmid:2160511
Randolph RK et al. Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low density lipoprotein receptor pathway. 1984 J. Lipid Res. pmid:6491537
Pandak WM et al. Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. 1992 J. Lipid Res. pmid:1619360
Field FJ and Mathur SN Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells. 1983 J. Lipid Res. pmid:6631233