Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Kim JH et al. Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts. 2016 Microb. Cell Fact. pmid:28010736
Kolawole EM et al. Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. 2016 J. Immunol. pmid:26773154
Huang Y et al. De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii. 2016 PLoS ONE pmid:26752526
Yildirim FI et al. Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. 2015 Prostaglandins Other Lipid Mediat. pmid:26201058
Surup F et al. Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. 2015 J. Nat. Prod. pmid:25871540
York AG et al. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. 2015 Cell pmid:26686653
Miettinen TP and Björklund M Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. 2015 Cell Rep pmid:26686643
Gallagher KA and Jensen PR Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. 2015 BMC Genomics pmid:26578069
Nyati P et al. Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. 2015 PLoS ONE pmid:26566274
Chen Y et al. Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. 2015 Lipids Health Dis pmid:26493087
Laezza C et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. 2015 Cell Death Dis pmid:26469958
Rondini EA et al. Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. 2015 J. Pharmacol. Exp. Ther. pmid:26427720
Guan Z et al. Metabolic engineering of Bacillus subtilis for terpenoid production. 2015 Appl. Microbiol. Biotechnol. pmid:26373726
Pandyra AA et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. 2015 Oncotarget pmid:26353928
Kuo KK et al. Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss. 2015 J. Lipid Res. pmid:26351364
Kain V et al. Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. 2015 Sci Rep pmid:26345110
Henry LK et al. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26216978
Zhang Z et al. Genomic variations of the mevalonate pathway in porokeratosis. 2015 Elife pmid:26202976
Venkateshwaran M et al. A role for the mevalonate pathway in early plant symbiotic signaling. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26199419
Tricarico PM et al. Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link. 2015 Int J Mol Sci pmid:26184189
Kobayashi Y et al. Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models. 2015 Clin. Cancer Res. pmid:26109099
Tricarico PM et al. Alendronate, a double-edged sword acting in the mevalonate pathway. 2015 Mol Med Rep pmid:26096667
Hofberger JA et al. Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants. 2015 PLoS ONE pmid:26046541
Karlic H et al. Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells. 2015 Cancer Genet pmid:25978957
Zhou X et al. Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation. 2015 Mol Med Rep pmid:25936991
Du X et al. Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots. 2015 Molecules pmid:25919278
Chen GP et al. Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process. 2015 J Diabetes Res pmid:25918730
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
Hwang HS et al. Transcriptomic analysis of Siberian ginseng (Eleutherococcus senticosus) to discover genes involved in saponin biosynthesis. 2015 BMC Genomics pmid:25888223
Hirota Y et al. Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. 2015 PLoS ONE pmid:25874989
Autefage H et al. Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25831522
Wang WQ et al. Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by polyethylene glycol fractionation. 2015 Plant Physiol. pmid:25736209
Sekiya A et al. Fluvastatin Upregulates the Expression of Tissue Factor Pathway Inhibitor in Human Umbilical Vein Endothelial Cells. 2015 J. Atheroscler. Thromb. pmid:25735397
Polotskaia A et al. Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25733866
de Oliveira LS et al. New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). 2015 Mar Drugs pmid:25675000
Rossoni L et al. The Putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene. 2015 Appl. Environ. Microbiol. pmid:25636853
Skaff DA et al. Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. 2015 Arch. Biochem. Biophys. pmid:25499551
Kang S et al. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. 2015 Eur J Med Chem pmid:25461893
Matsuo S et al. Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension. 2015 J. Thorac. Cardiovasc. Surg. pmid:25454916
Vinokur JM et al. Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. 2015 Protein Sci. pmid:25422158
Greife A et al. Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation. 2015 Tumour Biol. pmid:25566959
Yuan J and Ching CB Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. 2014 Biotechnol. Bioeng. pmid:24122315
Liu YP et al. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. 2014 J. Clin. Invest. pmid:24691443
Song AA et al. Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. 2014 FEMS Microbiol. Lett. pmid:24828482
Tricarico PM et al. Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. 2014 Int J Mol Sci pmid:24758928
Azami Y et al. (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. 2014 J. Biol. Chem. pmid:24755225
Zheng X et al. Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. 2014 Int J Mol Sci pmid:24722569
Liu Y et al. Caenorhabditis elegans pathways that surveil and defend mitochondria. 2014 Nature pmid:24695221
Ghavami S et al. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. 2014 Biochim. Biophys. Acta pmid:24637330
Kiser PD et al. Chemistry of the retinoid (visual) cycle. 2014 Chem. Rev. pmid:23905688