Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Hecht S et al. | Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11752431 |
Han YS et al. | Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. | 2002 | Phytochemistry | pmid:11754943 |
Ferri N et al. | Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. | 2001 | Biochem. Pharmacol. | pmid:11755117 |
Izumo N et al. | Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. | 2001 | Methods Find Exp Clin Pharmacol | pmid:11771853 |
Richard SB et al. | Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. | 2002 | J. Biol. Chem. | pmid:11786530 |
Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
Holstein SA et al. | Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. | 2002 | J. Biol. Chem. | pmid:11788600 |
pmid:11794213 | ||||
Hurtado-Guerrrero R et al. | Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. | 2002 | FEBS Lett. | pmid:11801242 |
pmid:11810250 | ||||
Rohdich F et al. | Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818558 |
Goodman ZD and Lequire VS | Transfer of esterified cholesterol from serum lipoproteins to the liver. | 1975 | Biochim. Biophys. Acta | pmid:1182142 |
pmid:11829504 | ||||
Thiel R and Adam KP | Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. | 2002 | Phytochemistry | pmid:11830134 |
Chmielewski M et al. | Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. | 2001 | Mol. Cell. Biochem. | pmid:11855739 |
Eisenreich W et al. | Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. | 2002 | J. Org. Chem. | pmid:11856031 |
pmid:11856612 | ||||
Kalinowski L et al. | Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. | 2002 | Circulation | pmid:11864921 |
Yokoyama K et al. | HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. | 2002 | Circulation | pmid:11864926 |
Fu Z et al. | The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. | 2002 | J. Biol. Chem. | pmid:11877411 |
Blanco-Colio LM et al. | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. | 2002 | Atherosclerosis | pmid:11882313 |
Ledoux S et al. | Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases. | 2002 | Circ. Res. | pmid:11884371 |
Paris D et al. | Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. | 2002 | Atherosclerosis | pmid:11888511 |
Gubina E et al. | CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. | 2002 | Blood | pmid:11895788 |
pmid:1193282 | ||||
pmid:1193283 | ||||
Virtanen SS et al. | Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | 2002 | Cancer Res. | pmid:11980672 |
pmid:11987326 | ||||
pmid:11995814 | ||||
Masferrer A et al. | Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. | 2002 | Plant J. | pmid:12000449 |
pmid:12002344 | ||||
Okada K et al. | Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. | 2002 | Planta | pmid:12029484 |
pmid:12031835 | ||||
Hamano Y et al. | Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036054 |
Marino M et al. | Age-related changes of cholesterol and dolichol biosynthesis in rat liver. | 2002 | Mech. Ageing Dev. | pmid:12044967 |
pmid:12059229 | ||||
Che P et al. | Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. | 2002 | Plant Physiol. | pmid:12068107 |
Konrad Z and Eichler J | Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. | 2002 | Biochem. J. | pmid:12069685 |
Dimitroulakos J et al. | Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. | 2002 Jul-Aug | Neoplasia | pmid:12082550 |
pmid:12091000 | ||||
Sul D and Kaneshiro ES | Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. | 2001 Mar-Apr | J. Eukaryot. Microbiol. | pmid:12095106 |
Porter KE et al. | Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. | 2002 | J. Vasc. Surg. | pmid:12096273 |
Newton CJ et al. | Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. | 2002 | J. Endocrinol. | pmid:12098658 |
Sutherlin A et al. | Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. | 2002 | J. Bacteriol. | pmid:12107122 |
Kumar B et al. | Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | 2002 | J. Neurosci. Res. | pmid:12111853 |
Fang TY and Baisted DJ | 2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds. | 1975 | Biochem. J. | pmid:1212194 |
Christ M et al. | Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. | 2002 | Diabetes | pmid:12145183 |
pmid:12162608 | ||||
Zager RA et al. | The mevalonate pathway during acute tubular injury: selected determinants and consequences. | 2002 | Am. J. Pathol. | pmid:12163393 |
Li L et al. | Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. | 2002 | Mol. Pharmacol. | pmid:12181436 |
Kandoussi A et al. | HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells. | 2002 | Clin. Sci. | pmid:12193060 |
Fahien LA and MacDonald MJ | The succinate mechanism of insulin release. | 2002 | Diabetes | pmid:12196457 |
Miyazaki A et al. | Effects of pravastatin sodium on mevalonate metabolism in common marmosets. | 2002 | J. Biochem. | pmid:12204108 |
pmid:12208479 | ||||
Kasahara H et al. | Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. | 2002 | J. Biol. Chem. | pmid:12228237 |
Amin R et al. | Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235236 |
Miyashita Y et al. | Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | 2002 | J. Atheroscler. Thromb. | pmid:12238640 |
pmid:12352324 | ||||
Kuzuyama T | Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12353619 |
Pappu AS et al. | Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. | 2002 | J. Lipid Res. | pmid:12364550 |
Hümbelin M et al. | Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. | 2002 | Gene | pmid:12384294 |
Stamatakis K et al. | Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. | 2002 | J. Biol. Chem. | pmid:12384510 |
Frenkel J et al. | Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | 2002 | Arthritis Rheum. | pmid:12384940 |
Mason JC et al. | Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. | 2002 | Circ. Res. | pmid:12386146 |
Carnesecchi S et al. | Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12388655 |
Nishikimi T et al. | Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin. | 2002 | Eur. J. Pharmacol. | pmid:12398901 |
Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
Parhami F et al. | Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. | 2002 | J. Bone Miner. Res. | pmid:12412807 |
Wagner AH et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12426205 |
Holstein SA et al. | Isoprenoids influence expression of Ras and Ras-related proteins. | 2002 | Biochemistry | pmid:12427032 |
RodrÃguez-Concepción M and Boronat A | Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. | 2002 | Plant Physiol. | pmid:12427975 |
Wang W et al. | Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines. | 2002 | FEBS Lett. | pmid:12435585 |
pmid:12444096 | ||||
Martin PD et al. | Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers. | 2002 | Br J Clin Pharmacol | pmid:12445025 |
Nagata N et al. | Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. | 2002 | Planta | pmid:12447549 |
Phillips GT and Clifford KH | Stereochemistry of a methyl-group rearrangement during the biosynthesis of lanosterol. | 1976 | Eur. J. Biochem. | pmid:1245185 |
Arkwright PD et al. | Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. | 2002 | Clin. Exp. Immunol. | pmid:12452839 |
pmid:12467639 | ||||
Naidu A et al. | Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. | 2002 | Brain Res. | pmid:12468034 |
Choi M et al. | Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. | 2003 | Kidney Int. | pmid:12472772 |
Alla S et al. | [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. | 2002 | C. R. Biol. | pmid:12481687 |
pmid:12492458 | ||||
pmid:12499535 | ||||
pmid:12503192 | ||||
pmid:12504097 | ||||
pmid:12509999 | ||||
Kalinowski L et al. | Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. | 2002 | J. Physiol. Pharmacol. | pmid:12512694 |
Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
Miyazawa Y et al. | Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. | 2002 | Plant Cell Physiol. | pmid:12514251 |
Peffley DM and Gayen AK | Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. | 2003 | J. Nutr. | pmid:12514264 |
Kreck M et al. | Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols. | 2003 | J. Agric. Food Chem. | pmid:12517111 |
Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
Kuzuyama T et al. | Detection of the mevalonate pathway in Streptomyces species using the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. | 2002 | J. Antibiot. | pmid:12523826 |
pmid:12525568 | ||||
pmid:12528472 | ||||
Shimada Y et al. | Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. | 2003 | Plant Physiol. | pmid:12529536 |
Sever N et al. | Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. | 2003 | Mol. Cell | pmid:12535518 |
Gober HJ et al. | Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. | 2003 | J. Exp. Med. | pmid:12538656 |
pmid:12543573 | ||||
pmid:12563048 |