| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Bell FP | Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. | 1976 | Exp. Mol. Pathol. | pmid:1001402 |
| Yoshida T et al. | Plasma levels of mevalonate and 7alpha-hydroxy-4-cholesten-3-one in chronic liver disease. | 1999 | J. Gastroenterol. Hepatol. | pmid:10029296 |
| Mutoh T et al. | Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. | 1999 | FEBS Lett. | pmid:10037153 |
| Vion-Dury J et al. | Atlas of brain proton magnetic resonance spectra. Part II: Inherited metabolic encephalopathies. | 1998 | J Neuroradiol | pmid:10048272 |
| Bassa BV et al. | Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. | 1999 | Biochim. Biophys. Acta | pmid:10082972 |
| Choi JW and Jung SE | Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10087052 |
| Parmryd I and Dallner G | In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups. | 1999 | Arch. Biochem. Biophys. | pmid:10190969 |
| Niku-Paavola ML et al. | New types of antimicrobial compounds produced by Lactobacillus plantarum. | 1999 | J. Appl. Microbiol. | pmid:10200070 |
| pmid:10216221 | ||||
| van beek E et al. | The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates. | 1999 | J. Bone Miner. Res. | pmid:10320520 |
| pmid:10333388 | ||||
| Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
| Naoumova RP et al. | Effect of inhibiting HMG-CoA reductase on 7 alpha-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathway. | 1999 | Eur. J. Clin. Invest. | pmid:10354197 |
| Cenedella RJ et al. | Lens epithelia contain a high-affinity, membrane steroid hormone-binding protein. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10359327 |
| Kikuchi A et al. | Evidence for covalent attachment of diphytanylglyceryl phosphate to the cell-surface glycoprotein of Halobacterium halobium. | 1999 | J. Biol. Chem. | pmid:10364251 |
| pmid:10369261 | ||||
| Girgert R et al. | Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms. | 1999 | Cancer Lett. | pmid:10374838 |
| Rao S et al. | Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393901 |
| Bifulco M et al. | Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells. | 1999 | Biochimie | pmid:10401660 |
| Rha SY et al. | Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer. | 1999 | Int. J. Mol. Med. | pmid:10402490 |
| pmid:10413074 | ||||
| Laufs U et al. | 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). | 1999 | J. Biol. Chem. | pmid:10419514 |
| pmid:10423031 | ||||
| Ghosh PM et al. | Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. | 1999 | Oncogene | pmid:10435593 |
| Vega GL et al. | Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol. | 1999 | J. Intern. Med. | pmid:10447220 |
| Bacurau RF et al. | Metabolic response of macrophages to injury promoted by the activated complement system. | 1999 | Cell Biochem. Funct. | pmid:10451538 |
| Ginger ML et al. | Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana. | 1999 | Biochem. J. | pmid:10455027 |
| Sato R et al. | Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. | 1999 | J. Biol. Chem. | pmid:10455139 |
| pmid:10460692 | ||||
| Parmryd I et al. | Protein prenylation in spinach chloroplasts. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10468564 |
| Appelkvist EL et al. | Synthesis of mevalonate pathway lipids in fibroblasts from Zellweger and X-linked ALD patients. | 1999 | Pediatr. Res. | pmid:10473053 |
| Agarwal B et al. | Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. | 1999 | Clin. Cancer Res. | pmid:10473109 |
| Jomaa H et al. | Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | 1999 | Science | pmid:10477522 |
| Koch T et al. | Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. | 1999 | Plant Physiol. | pmid:10482670 |
| Ravid T et al. | Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells. | 1999 | J. Biol. Chem. | pmid:10506194 |
| pmid:10527548 | ||||
| pmid:10527849 | ||||
| Gardner RG and Hampton RY | A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. | 1999 | J. Biol. Chem. | pmid:10531376 |
| Giordano W et al. | Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi. | 1999 | Microbiology (Reading, Engl.) | pmid:10537222 |
| Shack S et al. | Activation of the cholesterol pathway and Ras maturation in response to stress. | 1999 | Oncogene | pmid:10557091 |
| Kaul D and Kaur M | Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27). | 1999 | Mol. Cell. Biochem. | pmid:10569199 |
| Lange BM and Croteau R | Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570138 |
| Reszka AA et al. | Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. | 1999 | J. Biol. Chem. | pmid:10574973 |
| pmid:10591153 | ||||
| Kim DY et al. | Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. | 1999 | Protein Expr. Purif. | pmid:10600463 |
| Keller RK and Fliesler SJ | Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10600541 |
| Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
| Elkin RG and Yan Z | Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens. | 1999 | J. Reprod. Fertil. | pmid:10615252 |
| Kim SI et al. | Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. | 2000 | J. Am. Soc. Nephrol. | pmid:10616843 |
| Bergstrom JD et al. | Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. | 2000 | Arch. Biochem. Biophys. | pmid:10620343 |
| Szkopińska A et al. | The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623644 |
| Aboushadi N et al. | Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. | 2000 | Biochemistry | pmid:10625499 |
| Wagner AH et al. | Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10634801 |
| Lindenthal B and von Bergmann K | Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. | 2000 | Metab. Clin. Exp. | pmid:10647065 |
| Kuzuyama T et al. | Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. | 2000 | J. Bacteriol. | pmid:10648511 |
| Haratake A et al. | Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. | 2000 | J. Invest. Dermatol. | pmid:10651982 |
| Cvejić JH and Rohmer M | CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. | 2000 | Phytochemistry | pmid:10656403 |
| pmid:10665838 | ||||
| Hanley K et al. | Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. | 2000 | J. Invest. Dermatol. | pmid:10692116 |
| Lambert M and Bui ND | Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells. | 1999 | Mol. Cell. Biochem. | pmid:10706000 |
| pmid:10728920 | ||||
| Turunen M et al. | Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. | 2000 | J. Mol. Biol. | pmid:10731415 |
| Flach J et al. | The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733934 |
| Hashimoto F et al. | Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. | 2000 | Biochem. Pharmacol. | pmid:10736420 |
| Coppens I et al. | Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. | 2000 | J. Cell Biol. | pmid:10747095 |
| Tanaka T et al. | Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 2000 | J. Neurosci. | pmid:10751437 |
| pmid:10774794 | ||||
| Woo JT et al. | Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. | 2000 | J. Bone Miner. Res. | pmid:10780857 |
| Leonardsen L et al. | Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. | 2000 | J. Reprod. Fertil. | pmid:10793639 |
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| pmid:10814523 | ||||
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| Vishnuvardhan D and Beinfeld MC | Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. | 2000 | Peptides | pmid:10822111 |
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| Raal FJ et al. | Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. | 2000 | Atherosclerosis | pmid:10856535 |
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| pmid:10896295 | ||||
| pmid:10896296 | ||||
| pmid:10899 | ||||
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