| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Loregger A et al. | Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28882874 |
| Yamashita Y et al. | A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. | 2017 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:28603204 |
| Ye L et al. | Type IIs restriction based combinatory modulation technique for metabolic pathway optimization. | 2017 | Microb. Cell Fact. | pmid:28302121 |
| Agabiti SS et al. | Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. | 2017 | Cell Death Dis | pmid:28300835 |
| Kuzuyama T | Biosynthetic studies on terpenoids produced by Streptomyces. | 2017 | J. Antibiot. | pmid:28196976 |
| Cheng T et al. | Enzymatic process optimization for the in vitro production of isoprene from mevalonate. | 2017 | Microb. Cell Fact. | pmid:28068985 |
| Chen Q et al. | Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba. | 2017 | Molecules | pmid:28045448 |
| Kosek V et al. | High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway. | 2017 | J Chromatogr A | pmid:28209347 |
| Ding Y et al. | Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27864002 |
| Moutinho M et al. | The mevalonate pathway in neurons: It's not just about cholesterol. | 2017 | Exp. Cell Res. | pmid:28232115 |
| Tricarico PM et al. | 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28918367 |
| Montero-Villegas S et al. | Inhibition of Mevalonate Pathway and Synthesis of the Storage Lipids in Human Liver-Derived and Non-liver Cell Lines by Lippia alba Essential Oils. | 2017 | Lipids | pmid:27905068 |
| Feitosa AO et al. | Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27567521 |
| Fessler MB | The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response. | 2016 | Trends Immunol. | pmid:27692616 |
| Kim JH et al. | Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts. | 2016 | Microb. Cell Fact. | pmid:28010736 |
| Senkowski W et al. | Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids. | 2016 | Cell Chem Biol | pmid:27984028 |
| Ye L et al. | Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli. | 2016 | Microb. Cell Fact. | pmid:27905930 |
| Goldman AR et al. | The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. | 2016 | Mol. Cell Proteomics | pmid:27654507 |
| Wang J et al. | Engineering of a Highly Efficient Escherichia coli Strain for Mevalonate Fermentation through Chromosomal Integration. | 2016 | Appl. Environ. Microbiol. | pmid:27736790 |
| Parrales A et al. | DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. | 2016 | Nat. Cell Biol. | pmid:27775703 |
| Ruiz-Sola MÃ et al. | A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms. | 2016 | Plant Physiol. | pmid:27707890 |
| Miettinen TP and Björklund M | Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size. | 2016 | Dev. Cell | pmid:27720611 |
| Yamamoto K et al. | Enhancement of astaxanthin production in Xanthophyllomyces dendrorhous by efficient method for the complete deletion of genes. | 2016 | Microb. Cell Fact. | pmid:27624332 |
| Nerdal PT et al. | Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. | 2016 | J. Immunol. | pmid:27619996 |
| Terabe K et al. | Simvastatin inhibits CD44 fragmentation in chondrocytes. | 2016 | Arch. Biochem. Biophys. | pmid:27242325 |
| Agabiti SS et al. | Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. | 2016 | Mol. Membr. Biol. | pmid:27537059 |
| Rizvi F et al. | Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27335167 |
| Elsayed M et al. | Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. | 2016 | Biol. Pharm. Bull. | pmid:27181081 |
| Silva Ramos E et al. | Bioenergetic roles of mitochondrial fusion. | 2016 | Biochim. Biophys. Acta | pmid:27060252 |
| Leitmeyer K et al. | Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. | 2016 | Biomed Res Int | pmid:27051663 |
| Hashimoto A et al. | P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. | 2016 | J. Cell Biol. | pmid:27044891 |
| Cheng S et al. | Cloning, Expression Profiling and Functional Analysis of CnHMGS, a Gene Encoding 3-hydroxy-3-Methylglutaryl Coenzyme A Synthase from Chamaemelum nobile. | 2016 | Molecules | pmid:27005600 |
| Okin D and Medzhitov R | The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia. | 2016 | Cell | pmid:26997483 |
| Salunkhe VA et al. | Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. | 2016 | PLoS ONE | pmid:26986474 |
| Marcuzzi A et al. | Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. | 2016 | Int J Mol Sci | pmid:26978350 |
| Matsumoto Y et al. | A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. | 2016 | Sci Rep | pmid:26961421 |
| Zhu J et al. | Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. | 2016 | PLoS ONE | pmid:26959814 |
| Pina ES et al. | Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. | 2016 | Sci Rep | pmid:26943243 |
| Rodriguez S et al. | ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae. | 2016 | Microb. Cell Fact. | pmid:26939608 |
| Ignea C et al. | Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. | 2016 | Microb. Cell Fact. | pmid:26920948 |
| Cárdenas PD et al. | GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway. | 2016 | Nat Commun | pmid:26876023 |
| Tianero MD et al. | Metabolic model for diversity-generating biosynthesis. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26831074 |
| Daguzan C et al. | Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells. | 2016 | J. Immunol. | pmid:26819204 |
| Yang J et al. | A novel MVA-mediated pathway for isoprene production in engineered E. coli. | 2016 | BMC Biotechnol. | pmid:26786050 |
| Yang L et al. | Combinatorial engineering of hybrid mevalonate pathways in Escherichia coli for protoilludene production. | 2016 | Microb. Cell Fact. | pmid:26785630 |
| Kolawole EM et al. | Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. | 2016 | J. Immunol. | pmid:26773154 |
| Huang Y et al. | De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii. | 2016 | PLoS ONE | pmid:26752526 |
| Healey GD et al. | Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. | 2016 | J. Immunol. | pmid:26673142 |
| Torabi S and Mo H | Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26660152 |
| Jiang Z et al. | Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism. | 2016 | Plant Physiol. | pmid:26603654 |
| Mertens J et al. | The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. | 2016 | Plant Physiol. | pmid:26589673 |
| Garnett DJ | Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:26573510 |
| Wang T et al. | Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. | 2016 | Oncotarget | pmid:26565813 |
| Yildirim FI et al. | Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26201058 |
| Surup F et al. | Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. | 2015 | J. Nat. Prod. | pmid:25871540 |
| York AG et al. | Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. | 2015 | Cell | pmid:26686653 |
| Miettinen TP and Björklund M | Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. | 2015 | Cell Rep | pmid:26686643 |
| Gallagher KA and Jensen PR | Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. | 2015 | BMC Genomics | pmid:26578069 |
| Nyati P et al. | Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. | 2015 | PLoS ONE | pmid:26566274 |
| Chen Y et al. | Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. | 2015 | Lipids Health Dis | pmid:26493087 |
| Laezza C et al. | p53 regulates the mevalonate pathway in human glioblastoma multiforme. | 2015 | Cell Death Dis | pmid:26469958 |
| Rondini EA et al. | Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26427720 |
| Guan Z et al. | Metabolic engineering of Bacillus subtilis for terpenoid production. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26373726 |
| Pandyra AA et al. | Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. | 2015 | Oncotarget | pmid:26353928 |
| Kuo KK et al. | Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss. | 2015 | J. Lipid Res. | pmid:26351364 |
| Kain V et al. | Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. | 2015 | Sci Rep | pmid:26345110 |
| Henry LK et al. | Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26216978 |
| Zhang Z et al. | Genomic variations of the mevalonate pathway in porokeratosis. | 2015 | Elife | pmid:26202976 |
| Venkateshwaran M et al. | A role for the mevalonate pathway in early plant symbiotic signaling. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26199419 |
| Tricarico PM et al. | Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link. | 2015 | Int J Mol Sci | pmid:26184189 |
| Kobayashi Y et al. | Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models. | 2015 | Clin. Cancer Res. | pmid:26109099 |
| Tricarico PM et al. | Alendronate, a double-edged sword acting in the mevalonate pathway. | 2015 | Mol Med Rep | pmid:26096667 |
| Hofberger JA et al. | Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants. | 2015 | PLoS ONE | pmid:26046541 |
| Karlic H et al. | Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells. | 2015 | Cancer Genet | pmid:25978957 |
| Zhou X et al. | Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation. | 2015 | Mol Med Rep | pmid:25936991 |
| Du X et al. | Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots. | 2015 | Molecules | pmid:25919278 |
| Chen GP et al. | Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process. | 2015 | J Diabetes Res | pmid:25918730 |
| Sharon C et al. | Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. | 2015 | Oncotarget | pmid:25895029 |
| Hwang HS et al. | Transcriptomic analysis of Siberian ginseng (Eleutherococcus senticosus) to discover genes involved in saponin biosynthesis. | 2015 | BMC Genomics | pmid:25888223 |
| Hirota Y et al. | Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. | 2015 | PLoS ONE | pmid:25874989 |
| Autefage H et al. | Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25831522 |
| Wang WQ et al. | Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by polyethylene glycol fractionation. | 2015 | Plant Physiol. | pmid:25736209 |
| Sekiya A et al. | Fluvastatin Upregulates the Expression of Tissue Factor Pathway Inhibitor in Human Umbilical Vein Endothelial Cells. | 2015 | J. Atheroscler. Thromb. | pmid:25735397 |
| Polotskaia A et al. | Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25733866 |
| de Oliveira LS et al. | New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). | 2015 | Mar Drugs | pmid:25675000 |
| Rossoni L et al. | The Putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene. | 2015 | Appl. Environ. Microbiol. | pmid:25636853 |
| Skaff DA et al. | Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. | 2015 | Arch. Biochem. Biophys. | pmid:25499551 |
| Kang S et al. | Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. | 2015 | Eur J Med Chem | pmid:25461893 |
| Matsuo S et al. | Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension. | 2015 | J. Thorac. Cardiovasc. Surg. | pmid:25454916 |
| Vinokur JM et al. | Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. | 2015 | Protein Sci. | pmid:25422158 |
| Greife A et al. | Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation. | 2015 | Tumour Biol. | pmid:25566959 |
| Liu YP et al. | Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. | 2014 | J. Clin. Invest. | pmid:24691443 |
| Song AA et al. | Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. | 2014 | FEMS Microbiol. Lett. | pmid:24828482 |
| Tricarico PM et al. | Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. | 2014 | Int J Mol Sci | pmid:24758928 |
| Azami Y et al. | (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. | 2014 | J. Biol. Chem. | pmid:24755225 |
| Zheng X et al. | Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. | 2014 | Int J Mol Sci | pmid:24722569 |
| Liu Y et al. | Caenorhabditis elegans pathways that surveil and defend mitochondria. | 2014 | Nature | pmid:24695221 |
| Piłsyk S et al. | Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. | 2014 | Gene | pmid:24793581 |
| Ghavami S et al. | Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. | 2014 | Biochim. Biophys. Acta | pmid:24637330 |
| Kiser PD et al. | Chemistry of the retinoid (visual) cycle. | 2014 | Chem. Rev. | pmid:23905688 |