Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Loregger A et al. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28882874
Yamashita Y et al. A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. 2017 Nihon Rinsho Meneki Gakkai Kaishi pmid:28603204
Ye L et al. Type IIs restriction based combinatory modulation technique for metabolic pathway optimization. 2017 Microb. Cell Fact. pmid:28302121
Agabiti SS et al. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. 2017 Cell Death Dis pmid:28300835
Kuzuyama T Biosynthetic studies on terpenoids produced by Streptomyces. 2017 J. Antibiot. pmid:28196976
Cheng T et al. Enzymatic process optimization for the in vitro production of isoprene from mevalonate. 2017 Microb. Cell Fact. pmid:28068985
Chen Q et al. Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba. 2017 Molecules pmid:28045448
Kosek V et al. High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway. 2017 J Chromatogr A pmid:28209347
Ding Y et al. Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. 2017 J. Steroid Biochem. Mol. Biol. pmid:27864002
Moutinho M et al. The mevalonate pathway in neurons: It's not just about cholesterol. 2017 Exp. Cell Res. pmid:28232115
Tricarico PM et al. 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. 2017 Int. J. Biochem. Cell Biol. pmid:28918367
Montero-Villegas S et al. Inhibition of Mevalonate Pathway and Synthesis of the Storage Lipids in Human Liver-Derived and Non-liver Cell Lines by Lippia alba Essential Oils. 2017 Lipids pmid:27905068
Feitosa AO et al. Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). 2016 Jul - Sep Rev. Argent. Microbiol. pmid:27567521
Fessler MB The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response. 2016 Trends Immunol. pmid:27692616
Kim JH et al. Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts. 2016 Microb. Cell Fact. pmid:28010736
Senkowski W et al. Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids. 2016 Cell Chem Biol pmid:27984028
Ye L et al. Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli. 2016 Microb. Cell Fact. pmid:27905930
Goldman AR et al. The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. 2016 Mol. Cell Proteomics pmid:27654507
Wang J et al. Engineering of a Highly Efficient Escherichia coli Strain for Mevalonate Fermentation through Chromosomal Integration. 2016 Appl. Environ. Microbiol. pmid:27736790
Parrales A et al. DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. 2016 Nat. Cell Biol. pmid:27775703
Ruiz-Sola MÁ et al. A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms. 2016 Plant Physiol. pmid:27707890
Nerdal PT et al. Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. 2016 J. Immunol. pmid:27619996
Terabe K et al. Simvastatin inhibits CD44 fragmentation in chondrocytes. 2016 Arch. Biochem. Biophys. pmid:27242325
Agabiti SS et al. Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. 2016 Mol. Membr. Biol. pmid:27537059
Rizvi F et al. Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin. 2016 Am. J. Physiol., Cell Physiol. pmid:27335167
Elsayed M et al. Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. 2016 Biol. Pharm. Bull. pmid:27181081
Silva Ramos E et al. Bioenergetic roles of mitochondrial fusion. 2016 Biochim. Biophys. Acta pmid:27060252
Leitmeyer K et al. Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. 2016 Biomed Res Int pmid:27051663
Hashimoto A et al. P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. 2016 J. Cell Biol. pmid:27044891
Cheng S et al. Cloning, Expression Profiling and Functional Analysis of CnHMGS, a Gene Encoding 3-hydroxy-3-Methylglutaryl Coenzyme A Synthase from Chamaemelum nobile. 2016 Molecules pmid:27005600
Okin D and Medzhitov R The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia. 2016 Cell pmid:26997483
Salunkhe VA et al. Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. 2016 PLoS ONE pmid:26986474
Marcuzzi A et al. Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. 2016 Int J Mol Sci pmid:26978350
Matsumoto Y et al. A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. 2016 Sci Rep pmid:26961421
Zhu J et al. Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. 2016 PLoS ONE pmid:26959814
Pina ES et al. Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. 2016 Sci Rep pmid:26943243
Rodriguez S et al. ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae. 2016 Microb. Cell Fact. pmid:26939608
Ignea C et al. Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. 2016 Microb. Cell Fact. pmid:26920948
Cárdenas PD et al. GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway. 2016 Nat Commun pmid:26876023
Tianero MD et al. Metabolic model for diversity-generating biosynthesis. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26831074
Daguzan C et al. Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells. 2016 J. Immunol. pmid:26819204
Yang J et al. A novel MVA-mediated pathway for isoprene production in engineered E. coli. 2016 BMC Biotechnol. pmid:26786050
Yang L et al. Combinatorial engineering of hybrid mevalonate pathways in Escherichia coli for protoilludene production. 2016 Microb. Cell Fact. pmid:26785630
Kolawole EM et al. Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. 2016 J. Immunol. pmid:26773154
Huang Y et al. De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii. 2016 PLoS ONE pmid:26752526
Healey GD et al. Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. 2016 J. Immunol. pmid:26673142
Torabi S and Mo H Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation. 2016 Exp. Biol. Med. (Maywood) pmid:26660152
Jiang Z et al. Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism. 2016 Plant Physiol. pmid:26603654
Mertens J et al. The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. 2016 Plant Physiol. pmid:26589673
Wang T et al. Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. 2016 Oncotarget pmid:26565813