Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
DE WAARD A and POPJAK G Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations. 1959 Biochem. J. pmid:13815126
Wood SG and Gottlieb D Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637849
Wood SG and Gottlieb D Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637850
Smith AG and Goad LJ Sterol biosynthesis by the sea urchin Echinus esculentus. 1974 Biochem. J. pmid:4441383
Rasmussen LM et al. Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. 2001 Biochem. J. pmid:11716764
DIPLOCK AT et al. VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. 1965 Biochem. J. pmid:14333548
GOODWIN TW and WILLIAMS RJ A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. 1965 Biochem. J. pmid:14342248
Metz SA et al. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. 1993 Biochem. J. pmid:8216234
Graham JM and Green C The binding of sterols in cellular membranes. 1967 Biochem. J. pmid:6032974
Hitchcock CA et al. Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. 1990 Biochem. J. pmid:2180400
Ranganathan S and Ramasarma T The regulation of the biosynthesis of ubiquinone in the rat. 1975 Biochem. J. pmid:1156398
Cohen LH and Griffioen M Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites. 1988 Biochem. J. pmid:2848511
Gough DP and Hemming FW The characterization and stereochemistry of biosynthesis of dolichols in rat liver. 1970 Biochem. J. pmid:4319540
Stone KJ and Hemming FW The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. 1965 Biochem. J. pmid:4284430
Walton MJ and Pennock JF Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. 1972 Biochem. J. pmid:4403925
Higgins MJ and Kekwick RG An investigation into the role of malonyl-coenzyme A in isoprenoid biosynthesis. 1973 Biochem. J. pmid:4579226
Fang TY and Baisted DJ 2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds. 1975 Biochem. J. pmid:1212194
Beedle AS et al. Some properties and a suggested reclassification of mevaldate reductase. 1974 Biochem. J. pmid:4463942
Greenwood DR and Rees HH Mechanism of hydroxylation at C-22 during the biosynthesis of ecdysteroids in the locust Schistocerca gregaria. 1982 Biochem. J. pmid:7165737
Smith AG and Goad LJ Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. 1971 Biochem. J. pmid:5126917
Gibbons GF and Mitropoulos KA Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. 1972 Biochem. J. pmid:5073750
McDermott JC et al. Carotenoid biosynthesis in a Flavobacterium sp.: stereochemistry of hydrogen elimination in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin. 1973 Biochem. J. pmid:4762756
Ranganathan S and Ramasarma T Inhibition of the biosynthesis of sterols by phenyl and phenolic compounds in rat liver. 1973 Biochem. J. pmid:4749274
Gray JC and Kekwick RG Mevalonate kinase in green leaves and etiolated cotyledons of the french bean Phaseolus vulgaris. 1973 Biochem. J. pmid:4723778
Bassett RA et al. Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul. 1973 Biochem. J. pmid:4723222
Beedle AS et al. Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol. 1974 Biochem. J. pmid:4140721
Goodwin TW Recent developments in the study of the biosynthesis of carotenoids. 1972 Biochem. J. pmid:5085548
Mitropoulos KA and Myant NB Evidence that the oxidation of the side chain of cholesterol by liver mitochondria is stereospecific, and that the immediate product of cleavage is propionate. 1965 Biochem. J. pmid:5881647
Durr IF and Habbal MZ The biosynthesis of C 55 polyprenols by a cell-free preparation of Lactobacillus plantarum. 1972 Biochem. J. pmid:5076663
Leijten L et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in mouse uterine epithelial cells. 1987 Biochem. J. pmid:3032158
Baisted DJ Sterol and triterpene synthesis in the developing and germinating pea seed. 1971 Biochem. J. pmid:5158507
GOSSELIN L and POPJAK G Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid. 1959 Biochem. J. pmid:13651113
Skilleter DN and Kekwick RG The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis. 1971 Biochem. J. pmid:4333851
Goodwin TW Biosynthesis of carotenoids and plant triterpenes. 1971 Biochem. J. pmid:4331177
Bloxham DP and Akhtar M Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. 1971 Biochem. J. pmid:4331371
Olson RJ et al. Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids. 1974 Biochem. J. pmid:4441387
Tefft RE et al. Aspects of the stereochemistry of torularhodin biosynthesis. 1970 Biochem. J. pmid:5465554
Castagnoli N et al. Biosynthesis of N-(alpha-hydroxyethyl) lysergamide, a metabolite of Claviceps paspali Stevens and Hall. 1970 Biochem. J. pmid:5419742
Gough DP and Hemming FW The stereochemistry of betulaprenol biosynthesis. 1970 Biochem. J. pmid:4315982
Krishnaiah KV and Ramasarma T Effect of alpha-p-chlorophenoxyisobutyrate on the metabolism of isoprenoid compounds in the rat. 1970 Biochem. J. pmid:5435680
Sargent JR et al. Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. 1970 Biochem. J. pmid:5420034
Boogaard A et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. 1987 Biochem. J. pmid:3036060
Stone KJ and Hemming FW The stereochemistry of hexahydroprenol, ubiquinone and ergosterol biosynthesis in the mycelium of Aspergillus fumigatus Fresenius. 1967 Biochem. J. pmid:4292001
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Cornforth JW and Cornforth RH Chemistry of mevalonic acid. 1969 Biochem. J. pmid:5807184
Rudney H The biosynthesis of terpenoid quinones. 1969 Biochem. J. pmid:4308944
Noddle RC and Robinson DR Biosynthesis of abscisic acid: incorporation of radioactivity from [2-14C]mevalonic acid by intact fruit. 1969 Biochem. J. pmid:4308332
Atkin SD et al. The role of cytochrome P-450 in cholesterol biogenesis and catabolism. 1972 Biochem. J. pmid:5084788
Williams RJ et al. The stereospecific biosynthesis of phytoene and polyunsaturated carotenes. 1967 Biochem. J. pmid:6049923
Wellburn AR and Hemming FW The subcellular distribution and biosynthesis of castaprenols and plastoquinone in the leaves of Aesculus hippocastanum. 1967 Biochem. J. pmid:6068175
Threlfall DR et al. Biosynthesis of the prenyl side chains of plastoquinone and related compounds in maize and barley shoots. 1967 Biochem. J. pmid:6049407
Rodwell VW Cholesterol regulation of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1972 Biochem. J. pmid:5085556
Akhtar M et al. The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. 1969 Biochem. J. pmid:5783476
De Matteis F Stimulation of liver cholesterol synthesis by actinomycin D. 1968 Biochem. J. pmid:5696865
Williamson IP and Kekwick RG The formation of 5-phosphomevalonate by mevalonate kinase in Hevea brasiliensis latex. 1965 Biochem. J. pmid:5862423
Shama Bhat C and Ramasarma T Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. 1979 Biochem. J. pmid:226078
Montalvetti A et al. Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase. 2000 Biochem. J. pmid:10861207
Madyastha KM et al. Carboxyl group methylation of loganic acid by a cell-free enzyme preparation from Vinca rosea. 1972 Biochem. J. pmid:4404427
BRAITHWAITE GD and GOODWIN TW Studies in carotenogenesis. 27. Incorporation of [2-14C] acetate, DL-[2-14C] mevalonate and C14-labelled carbon dioxide into carrotroot preparations. 1960 Biochem. J. pmid:13849153
BRAITHWAITE GD and GOODWIN TW Studies in carotenogenesis. 26. The incorporation of [C14] acetate, [C14] mevalonate and C14-labelled carbon dioxide into beta-carotene by the fungus Phycomyces blakesleeanus. 1960 Biochem. J. pmid:13849152
Rohmer M et al. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. 1993 Biochem. J. pmid:8240251
GOODWIN TW Studies in carotenogenesis. 25. The incorporation of 14CO2, [2-14C] acetate and [2-14C]mevalonate into beta-carotene by illuminated etiolated maize seedings. 1958 Biochem. J. pmid:13607416
Goad LJ Sterol biosynthesis. 1969 Biochem. J. pmid:5807186
Goodwin TW and Williams RJ A mechanism for the biosynthesis of alpha-carotene. 1965 Biochem. J. pmid:5881648
Walton TJ et al. Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. 1969 Biochem. J. pmid:5801311
Cohen LH et al. Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2. 1984 Biochem. J. pmid:6089762
Ruiz-Velasco N et al. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. 2004 Biochem. Pharmacol. pmid:14698043
Burton PM et al. Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity. 1995 Biochem. Pharmacol. pmid:7646560
Teal SW and Gamble W Effect of p-chlorophenoxyisobutyric acid, ethyl p-chlorophenoxyisobutyrate, and Atromid on the synthesis of nonsaponifiable material and cholesterol in the bovine aorta. 1965 Biochem. Pharmacol. pmid:5840738
Ren Z et al. Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. 1997 Biochem. Pharmacol. pmid:9296357
Ferri N et al. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. 2001 Biochem. Pharmacol. pmid:11755117
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. II. AY-9944 and AY-9944 plus zuclomiphene. 1977 Biochem. Pharmacol. pmid:70208
Kyathanahalli CN and Kowluru A A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. 2011 Biochem. Pharmacol. pmid:21406184
Okada K et al. Effect of 4-(4'-chlorobenzyloxy)benzyl nicotinate (KCD-232) on cholesterol metabolism in rats. 1985 Biochem. Pharmacol. pmid:4038342
Ben-Tal Cohen E et al. Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. 2007 Biochem. Pharmacol. pmid:17070781
Eskelson CD et al. Cholesterolgenesis in vitro from ethanol. 1970 Biochem. Pharmacol. pmid:5513929
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene. 1977 Biochem. Pharmacol. pmid:889582
Mitoma C et al. Effects of various chemical agents on drug metabolism and cholesterol biosynthesis. 1968 Biochem. Pharmacol. pmid:5659782
Johnson DF and Daly JW Biosynthesis of cholesterol and cholesterol acetate in dendrobatid arrow poison frogs. 1971 Biochem. Pharmacol. pmid:5114496
Goad LJ et al. Effect of the allylamine antifungal drug SF 86-327 on the growth and sterol synthesis of Leishmania mexicana mexicana promastigotes. 1985 Biochem. Pharmacol. pmid:4052119
Zhong WB et al. Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. 2011 Biochem. Pharmacol. pmid:21907187
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Hamadmad SN and Hohl RJ Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. 2007 Biochem. Pharmacol. pmid:17586475
Díaz Zagoya JC et al. Studies on the regulation of cholesterol metabolism by the use of the structural analogue, diosgenin. 1971 Biochem. Pharmacol. pmid:5132893
Porcellati G and Giorgini D The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. 1969 Biochem. Pharmacol. pmid:5772592
Plée-Gautier E et al. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. 2012 Biochem. Pharmacol. pmid:22634049
Takashima K et al. Effect of eritadenine on cholesterol metabolism in the rat. 1974 Biochem. Pharmacol. pmid:4813355
McTaggart F et al. Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines. 1996 Biochem. Pharmacol. pmid:8630089
Hashimoto F et al. Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. 2000 Biochem. Pharmacol. pmid:10736420
Mazein A et al. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. 2013 Biochem. Pharmacol. pmid:23583456
Nair N and Kurup CK Investigations on the mechanism of the hypocholesterolemic action of diethylhexyl phthalate in rats. 1986 Biochem. Pharmacol. pmid:3768033
Suzuki K Effects of S-8527 (1,1-bis(4'-(1'-carboxy-1'-methylpropoxy)phenyl) cyclohexane), a new hypolipidemic compound, on cholesterol and lipoprotein metabolism in rats. 1976 Biochem. Pharmacol. pmid:1267828
Klimov AN et al. Inhibition of biosynthesis of cholesterol by salicylate. 1969 Biochem. Pharmacol. pmid:5789791
Hoang VQ et al. The regulation of bile acid synthesis in cultured hamster hepatocytes. 1993 Biochem. Soc. Trans. pmid:8224434
Aspbury RA et al. Lipid modification of signal-transducing polypeptides in the free-living nematode Caenorhabditis elegans. 1995 Biochem. Soc. Trans. pmid:7758740
Goodwin TW Developments in carotenoid biochemistry over 40 years. The third Morton lecture. 1983 Biochem. Soc. Trans. pmid:6642057
Hebbachi AM and Gibbons GF Retention of orotic acid effect on very low density lipoproteins secretion in cultured hepatocytes. 1996 Biochem. Soc. Trans. pmid:8736835
Rilling HC The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture. 1985 Biochem. Soc. Trans. pmid:4092833
Merry AH et al. Oestrogen-stimulated cholesterol and lipid synthesis in Xenopus laevis liver. 1973 Biochem. Soc. Trans. pmid:4802550