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Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
2008 |
J. Immunol. |
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Simonen M et al. |
High-content assay to study protein prenylation. |
2008 |
J Biomol Screen |
pmid:18509097
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Lazzerini PE et al. |
Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. |
2007 Sep-Oct |
Clin. Exp. Rheumatol. |
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Yoon SH et al. |
Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. |
2007 May-Jun |
Biotechnol. Prog. |
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Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. |
2007 Mar-Apr |
Anticancer Res. |
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Bock O et al. |
Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. |
2007 Apr-Jun |
J Musculoskelet Neuronal Interact |
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Kuroda M et al. |
Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. |
2007 |
J. Antimicrob. Chemother. |
pmid:17242033
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Yoon SH et al. |
Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. |
2007 |
Appl. Microbiol. Biotechnol. |
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Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. |
2007 |
Int. Immunol. |
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Nishimoto T et al. |
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
2007 |
Toxicol. Appl. Pharmacol. |
pmid:17599378
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Honda A et al. |
Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. |
2007 |
J. Lipid Res. |
pmid:17272831
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Sarrabayrouse G et al. |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. |
2007 |
Neoplasia |
pmid:18084615
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Hao M et al. |
Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. |
2007 |
Diabetes |
pmid:17575085
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Mevalonic aciduria: report of two cases. |
2007 |
J. Inherit. Metab. Dis. |
pmid:17578678
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Ben-Tal Cohen E et al. |
Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. |
2007 |
Biochem. Pharmacol. |
pmid:17070781
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Igarashi J et al. |
Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. |
2007 |
Br. J. Pharmacol. |
pmid:17220911
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Parsons RB et al. |
A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. |
2007 |
J. Neurochem. |
pmid:17472704
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Haas D and Hoffmann GF |
Mevalonate kinase deficiency and autoinflammatory disorders. |
2007 |
N. Engl. J. Med. |
pmid:17596600
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Maurer-Stroh S et al. |
Towards complete sets of farnesylated and geranylgeranylated proteins. |
2007 |
PLoS Comput. Biol. |
pmid:17411337
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Llorente A et al. |
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. |
2007 |
Eur. J. Cell Biol. |
pmid:17601634
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Kettawan A et al. |
Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. |
2007 |
J Clin Biochem Nutr |
pmid:18398496
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Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:17303772
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Jahangir T and Sultana S |
Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. |
2007 |
Evid Based Complement Alternat Med |
pmid:18227911
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Li M et al. |
Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:17545489
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Hamadmad SN and Hohl RJ |
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. |
2007 |
Biochem. Pharmacol. |
pmid:17586475
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Corsini A et al. |
Are pleiotropic effects of statins real? |
2007 |
Vasc Health Risk Manag |
pmid:18078012
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Nakao T et al. |
Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. |
2007 |
J. Pharmacol. Sci. |
pmid:18057776
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Ali F et al. |
Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. |
2007 |
J. Thromb. Haemost. |
pmid:17927807
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Hu WL et al. |
Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. |
2007 |
Cytokine |
pmid:18023360
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Wong WW et al. |
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. |
2007 |
Mol. Cancer Ther. |
pmid:17575117
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Kutrzeba L et al. |
Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. |
2007 |
Phytochemistry |
pmid:17574635
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Wong J et al. |
Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. |
2007 |
Lipids Health Dis |
pmid:17408498
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Hunter WN |
The non-mevalonate pathway of isoprenoid precursor biosynthesis. |
2007 |
J. Biol. Chem. |
pmid:17442674
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Lopes AA et al. |
Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). |
2007 |
Phytochemistry |
pmid:17574633
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Takeda I et al. |
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. |
2007 |
Cancer Sci. |
pmid:17428261
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Roelofs AJ et al. |
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17412884
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Sgraja T et al. |
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. |
2007 |
BMC Struct. Biol. |
pmid:17397541
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Desai B et al. |
Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. |
2007 |
Mol. Cancer |
pmid:17343740
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D'Amico L et al. |
A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. |
2007 |
Curr. Biol. |
pmid:17276918
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Henriksson LM et al. |
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. |
2007 |
J. Biol. Chem. |
pmid:17491006
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Loiseau L et al. |
ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17698959
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Withers ST et al. |
Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. |
2007 |
Appl. Environ. Microbiol. |
pmid:17693564
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Buhaescu I and Izzedine H |
Mevalonate pathway: a review of clinical and therapeutical implications. |
2007 |
Clin. Biochem. |
pmid:17467679
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März P et al. |
Statins induce differentiation and cell death in neurons and astroglia. |
2007 |
Glia |
pmid:16998865
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Jantzen F et al. |
Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. |
2007 |
J. Physiol. Pharmacol. |
pmid:17928646
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Andreassi JL et al. |
Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. |
2007 |
Protein Sci. |
pmid:17400916
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Byres E et al. |
Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. |
2007 |
J. Mol. Biol. |
pmid:17583736
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Lee MH et al. |
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. |
2007 |
Stem Cells |
pmid:17464088
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Kinjoh T et al. |
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. |
2007 |
Insect Biochem. Mol. Biol. |
pmid:17628279
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Takahashi HK et al. |
Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. |
2007 |
Clin. Immunol. |
pmid:17482516
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