Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Zhang X et al. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 2008 J. Immunol. pmid:18453621
Simonen M et al. High-content assay to study protein prenylation. 2008 J Biomol Screen pmid:18509097
Lazzerini PE et al. Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. 2007 Sep-Oct Clin. Exp. Rheumatol. pmid:18078616
Yoon SH et al. Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. 2007 May-Jun Biotechnol. Prog. pmid:17500531
Matsunaga S et al. Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. 2007 Mar-Apr Anticancer Res. pmid:17465222
Bock O et al. Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. 2007 Apr-Jun J Musculoskelet Neuronal Interact pmid:17627083
Kuroda M et al. Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. 2007 J. Antimicrob. Chemother. pmid:17242033
Yoon SH et al. Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. 2007 Appl. Microbiol. Biotechnol. pmid:17115209
Tanaka T et al. Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. 2007 Int. Immunol. pmid:17182966
Nishimoto T et al. Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. 2007 Toxicol. Appl. Pharmacol. pmid:17599378
Honda A et al. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. 2007 J. Lipid Res. pmid:17272831
Sarrabayrouse G et al. Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. 2007 Neoplasia pmid:18084615
Hao M et al. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. 2007 Diabetes pmid:17575085
Bretón Martínez JR et al. Mevalonic aciduria: report of two cases. 2007 J. Inherit. Metab. Dis. pmid:17578678
Ben-Tal Cohen E et al. Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. 2007 Biochem. Pharmacol. pmid:17070781
Igarashi J et al. Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. 2007 Br. J. Pharmacol. pmid:17220911
Parsons RB et al. A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. 2007 J. Neurochem. pmid:17472704
Haas D and Hoffmann GF Mevalonate kinase deficiency and autoinflammatory disorders. 2007 N. Engl. J. Med. pmid:17596600
Maurer-Stroh S et al. Towards complete sets of farnesylated and geranylgeranylated proteins. 2007 PLoS Comput. Biol. pmid:17411337
Llorente A et al. Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. 2007 Eur. J. Cell Biol. pmid:17601634
Kettawan A et al. Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. 2007 J Clin Biochem Nutr pmid:18398496
Ferri N et al. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17303772
Jahangir T and Sultana S Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. 2007 Evid Based Complement Alternat Med pmid:18227911
Li M et al. Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17545489
Hamadmad SN and Hohl RJ Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. 2007 Biochem. Pharmacol. pmid:17586475
Corsini A et al. Are pleiotropic effects of statins real? 2007 Vasc Health Risk Manag pmid:18078012
Nakao T et al. Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. 2007 J. Pharmacol. Sci. pmid:18057776
Ali F et al. Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. 2007 J. Thromb. Haemost. pmid:17927807
Hu WL et al. Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. 2007 Cytokine pmid:18023360
Wong WW et al. Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. 2007 Mol. Cancer Ther. pmid:17575117
Kutrzeba L et al. Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. 2007 Phytochemistry pmid:17574635
Wong J et al. Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. 2007 Lipids Health Dis pmid:17408498
Hunter WN The non-mevalonate pathway of isoprenoid precursor biosynthesis. 2007 J. Biol. Chem. pmid:17442674
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
Takeda I et al. Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. 2007 Cancer Sci. pmid:17428261
Roelofs AJ et al. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2007 J. Pharmacol. Exp. Ther. pmid:17412884
Sgraja T et al. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. 2007 BMC Struct. Biol. pmid:17397541
Desai B et al. Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. 2007 Mol. Cancer pmid:17343740
D'Amico L et al. A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. 2007 Curr. Biol. pmid:17276918
Henriksson LM et al. Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. 2007 J. Biol. Chem. pmid:17491006
Loiseau L et al. ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17698959
Withers ST et al. Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. 2007 Appl. Environ. Microbiol. pmid:17693564
Buhaescu I and Izzedine H Mevalonate pathway: a review of clinical and therapeutical implications. 2007 Clin. Biochem. pmid:17467679
März P et al. Statins induce differentiation and cell death in neurons and astroglia. 2007 Glia pmid:16998865
Jantzen F et al. Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. 2007 J. Physiol. Pharmacol. pmid:17928646
Andreassi JL et al. Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. 2007 Protein Sci. pmid:17400916
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Lee MH et al. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. 2007 Stem Cells pmid:17464088
Kinjoh T et al. Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. 2007 Insect Biochem. Mol. Biol. pmid:17628279
Takahashi HK et al. Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. 2007 Clin. Immunol. pmid:17482516