| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
| Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
| Yuan J and Ching CB | Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. | 2014 | Biotechnol. Bioeng. | pmid:24122315 |
| Huchelmann A et al. | S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. | 2014 | Plant Physiol. | pmid:24367019 |
| Schwarz BH et al. | Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia. | 2014 | Biochim. Biophys. Acta | pmid:24316250 |
| Liu YP et al. | Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. | 2014 | J. Clin. Invest. | pmid:24691443 |
| Burgazli KM et al. | The impact of statins on FGF-2-stimulated human umbilical vein endothelial cells. | 2014 | Postgrad Med | pmid:24393759 |
| Hamid PH et al. | Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. | 2014 | Parasitol. Res. | pmid:25199551 |
| Moise AR et al. | Mechanistic aspects of carotenoid biosynthesis. | 2014 | Chem. Rev. | pmid:24175570 |
| Khandelwal VK et al. | Oxidative stress plays an important role in zoledronic acid-induced autophagy. | 2014 | Physiol Res | pmid:25669691 |
| Warita K et al. | Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. | 2014 | Sci Rep | pmid:25534349 |
| Chang TI et al. | The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. | 2014 | PLoS ONE | pmid:25275561 |
| Kanugula AK et al. | Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. | 2014 | PLoS ONE | pmid:25268751 |
| Sapir A et al. | Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25187565 |
| Rodriguez SB and Leyh TS | An enzymatic platform for the synthesis of isoprenoid precursors. | 2014 | PLoS ONE | pmid:25153179 |
| Jiang P et al. | In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. | 2014 | Br. J. Cancer | pmid:25093497 |
| Sivanandhan G et al. | Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. | 2014 | PLoS ONE | pmid:25089711 |
| Rastogi S et al. | De novo sequencing and comparative analysis of holy and sweet basil transcriptomes. | 2014 | BMC Genomics | pmid:25015319 |
| Fabris M et al. | Tracking the sterol biosynthesis pathway of the diatom Phaeodactylum tricornutum. | 2014 | New Phytol. | pmid:24996048 |
| Pandyra A et al. | Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. | 2014 | Cancer Res. | pmid:24994712 |
| Kanugula AK et al. | Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. | 2014 | FEBS J. | pmid:24964743 |
| Workalemahu G et al. | Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity. | 2014 | J. Immunol. | pmid:24943221 |
| Ranji P et al. | Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. | 2014 | PLoS ONE | pmid:24918786 |
| Vinokur JM et al. | Evidence of a novel mevalonate pathway in archaea. | 2014 | Biochemistry | pmid:24914732 |
| Wang Y et al. | 24S,25-Epoxycholesterol in mouse and rat brain. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24832732 |
| Xiong M et al. | Scalable production of mechanically tunable block polymers from sugar. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24912182 |
| Rivera-Perez C et al. | Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology. | 2014 | Insect Biochem. Mol. Biol. | pmid:24833260 |
| Song AA et al. | Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. | 2014 | FEMS Microbiol. Lett. | pmid:24828482 |
| Tricarico PM et al. | Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. | 2014 | Int J Mol Sci | pmid:24758928 |
| Azami Y et al. | (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. | 2014 | J. Biol. Chem. | pmid:24755225 |
| Zheng X et al. | Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. | 2014 | Int J Mol Sci | pmid:24722569 |
| Liu Y et al. | Caenorhabditis elegans pathways that surveil and defend mitochondria. | 2014 | Nature | pmid:24695221 |
| Piłsyk S et al. | Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. | 2014 | Gene | pmid:24793581 |
| Ghavami S et al. | Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. | 2014 | Biochim. Biophys. Acta | pmid:24637330 |
| Korman TP et al. | A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. | 2014 | Protein Sci. | pmid:24623472 |
| Yeganeh B et al. | Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. | 2014 | Pharmacol. Ther. | pmid:24582968 |
| Rojo-Arreola L et al. | Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. | 2014 | PLoS ONE | pmid:24489942 |
| Li J et al. | De novo synthesis of steroids and oxysterols in adipocytes. | 2014 | J. Biol. Chem. | pmid:24280213 |
| Sánchez-Solana B et al. | Cytosolic functions of MORC2 in lipogenesis and adipogenesis. | 2014 | Biochim. Biophys. Acta | pmid:24286864 |
| González-Caballero N et al. | Expression of the mevalonate pathway enzymes in the Lutzomyia longipalpis (Diptera: Psychodidae) sex pheromone gland demonstrated by an integrated proteomic approach. | 2014 | J Proteomics | pmid:24185139 |
| Pampalakis G et al. | The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. | 2014 | Oncotarget | pmid:24158494 |
| Bentley FK et al. | Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. | 2014 | Mol Plant | pmid:24157609 |
| Fu Z et al. | Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. | 2014 | Microb. Cell Fact. | pmid:24593159 |
| Kiser PD et al. | Chemistry of the retinoid (visual) cycle. | 2014 | Chem. Rev. | pmid:23905688 |
| Rachner TD et al. | Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. | 2014 | Breast Cancer Res. | pmid:24528599 |
| Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
| Theesfeld CL and Hampton RY | Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. | 2013 | J. Biol. Chem. | pmid:23306196 |
| van der Burgh R et al. | Mevalonate kinase deficiency, a metabolic autoinflammatory disease. | 2013 | Clin. Immunol. | pmid:23110805 |
| Hosaka A et al. | Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. | 2013 | Neurochem. Res. | pmid:23269484 |
| Qi XF et al. | HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. | 2013 | Cell Death Dis | pmid:23449454 |
| Tricarico PM et al. | Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study. | 2013 | Biomed Res Int | pmid:24073415 |
| Tyurin M | Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23649912 |
| MartÃn-Navarro CM et al. | Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections. | 2013 | Antimicrob. Agents Chemother. | pmid:23114753 |
| Zhang J et al. | Statins directly suppress cytokine production in murine intraepithelial lymphocytes. | 2013 | Cytokine | pmid:23290865 |
| Rauthan M et al. | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23530189 |
| Citron CA and Dickschat JS | The stereochemical course of tricho-acorenol biosynthesis. | 2013 | Org. Biomol. Chem. | pmid:24084795 |
| Blanc M et al. | The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. | 2013 | Immunity | pmid:23273843 |
| Wang C et al. | Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. | 2013 | Metab. Eng. | pmid:23608473 |
| Yu W et al. | The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion. | 2013 | Antimicrob. Agents Chemother. | pmid:23959312 |
| Szűcs G et al. | Cardioprotection by farnesol: role of the mevalonate pathway. | 2013 | Cardiovasc Drugs Ther | pmid:23673412 |
| Ramak P et al. | Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. | 2013 | J. Plant Physiol. | pmid:23611428 |
| Chen X et al. | Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. | 2013 | PLoS ONE | pmid:24278153 |
| Chang WC et al. | Current development in isoprenoid precursor biosynthesis and regulation. | 2013 | Curr Opin Chem Biol | pmid:23891475 |
| Tuerdi G et al. | Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. | 2013 | Cancer Lett. | pmid:23879968 |
| Gopalan A et al. | Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. | 2013 | Cancer Lett. | pmid:22960596 |
| Onono F et al. | Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. | 2013 | J. Biol. Chem. | pmid:23908355 |
| Gopalan A et al. | Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. | 2013 | Cancer Lett. | pmid:23063651 |
| Liu J et al. | Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. | 2013 | J. Biotechnol. | pmid:24161921 |
| Lee SK and Kim YS | Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. | 2013 | Int. J. Oncol. | pmid:23354132 |
| Valente AJ et al. | Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. | 2013 | Cell. Signal. | pmid:23541442 |
| Xiao H et al. | Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. | 2013 | PLoS ONE | pmid:23555637 |
| Villanueva JA et al. | Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. | 2013 | J. Clin. Endocrinol. Metab. | pmid:23386644 |
| May B et al. | Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. | 2013 | Phytochemistry | pmid:23954075 |
| Zeng H et al. | mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. | 2013 | Nature | pmid:23812589 |
| Chen B et al. | Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. | 2013 | Cell. Physiol. Biochem. | pmid:24356578 |
| Dellas N et al. | Discovery of a metabolic alternative to the classical mevalonate pathway. | 2013 | Elife | pmid:24327557 |
| Bruzzese F et al. | Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. | 2013 | Cell Death Dis | pmid:24157872 |
| Dick M et al. | Statin therapy influences endothelial cell morphology and F-actin cytoskeleton structure when exposed to static and laminar shear stress conditions. | 2013 | Life Sci. | pmid:23517776 |
| Fang SY et al. | Pleiotropic vascular protective effects of statins in perioperative medicine. | 2013 | Acta Anaesthesiol Taiwan | pmid:24148741 |
| Maciejak A et al. | The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. | 2013 | BMC Biotechnol. | pmid:24128347 |
| Polidoro S et al. | Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. | 2013 | Mutat. Res. | pmid:23892139 |
| Santolaria T et al. | Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. | 2013 | J. Immunol. | pmid:23836057 |
| Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
| Ohukainen P | If the wheel ain't broke, don't reinvent it. | 2013 | Lipids Health Dis | pmid:23577775 |
| Werner M et al. | Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23564041 |
| Zhu Y et al. | Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. | 2013 | Cell Death Dis | pmid:23559002 |
| Lee NY and Kang YS | The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions. | 2013 | Adv. Exp. Med. Biol. | pmid:23392871 |
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| Lesma E et al. | Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23426956 |
| Doblas VG et al. | The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. | 2013 | Plant Cell | pmid:23404890 |
| Riganti C et al. | Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. | 2013 | PLoS ONE | pmid:23593363 |
| Lazzerini PE et al. | Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. | 2013 | Joint Bone Spine | pmid:22999910 |
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| Liu D et al. | The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. | 2012 | PLoS ONE | pmid:22567134 |
| Yang J et al. | Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. | 2012 | PLoS ONE | pmid:22558074 |
| Fu X et al. | Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. | 2012 | J. Exp. Bot. | pmid:21994170 |
| Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106303 |
| Chow KS et al. | Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. | 2012 | J. Exp. Bot. | pmid:22162870 |
| Reiniers MJ et al. | 2',7'-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. | 2012 | J. Hepatol. | pmid:22127279 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |