Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Capra V and Rovati GE Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. 2014 Pulm Pharmacol Ther pmid:23806820
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Yuan J and Ching CB Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. 2014 Biotechnol. Bioeng. pmid:24122315
Sorrentino G et al. Metabolic control of YAP and TAZ by the mevalonate pathway. 2014 Nat. Cell Biol. pmid:24658687
Al-Haidari AA et al. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. 2014 Biochem. Biophys. Res. Commun. pmid:24582560
Huchelmann A et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. 2014 Plant Physiol. pmid:24367019
Schwarz BH et al. Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia. 2014 Biochim. Biophys. Acta pmid:24316250
Smith R et al. Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. 2014 PLoS ONE pmid:24416446
Burgazli KM et al. The impact of statins on FGF-2-stimulated human umbilical vein endothelial cells. 2014 Postgrad Med pmid:24393759
Hamid PH et al. Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. 2014 Parasitol. Res. pmid:25199551
Moise AR et al. Mechanistic aspects of carotenoid biosynthesis. 2014 Chem. Rev. pmid:24175570
Yang J and Guo L Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways. 2014 Microb. Cell Fact. pmid:25403509
Larson-Casey JL et al. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. 2014 J. Biol. Chem. pmid:25378391
Shimabukuro-Vornhagen A et al. Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. 2014 J. Immunol. pmid:25311809
Chang TI et al. The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. 2014 PLoS ONE pmid:25275561
Kanugula AK et al. Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. 2014 PLoS ONE pmid:25268751
Sapir A et al. Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25187565
Rodriguez SB and Leyh TS An enzymatic platform for the synthesis of isoprenoid precursors. 2014 PLoS ONE pmid:25153179
Jiang P et al. In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. 2014 Br. J. Cancer pmid:25093497
Sivanandhan G et al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. 2014 PLoS ONE pmid:25089711
Rastogi S et al. De novo sequencing and comparative analysis of holy and sweet basil transcriptomes. 2014 BMC Genomics pmid:25015319
Fabris M et al. Tracking the sterol biosynthesis pathway of the diatom Phaeodactylum tricornutum. 2014 New Phytol. pmid:24996048
Pandyra A et al. Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. 2014 Cancer Res. pmid:24994712
Kanugula AK et al. Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. 2014 FEBS J. pmid:24964743
Workalemahu G et al. Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity. 2014 J. Immunol. pmid:24943221
Ranji P et al. Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. 2014 PLoS ONE pmid:24918786
Vinokur JM et al. Evidence of a novel mevalonate pathway in archaea. 2014 Biochemistry pmid:24914732
Wang Y et al. 24S,25-Epoxycholesterol in mouse and rat brain. 2014 Biochem. Biophys. Res. Commun. pmid:24832732
Xiong M et al. Scalable production of mechanically tunable block polymers from sugar. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24912182
Rivera-Perez C et al. Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology. 2014 Insect Biochem. Mol. Biol. pmid:24833260
Song AA et al. Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. 2014 FEMS Microbiol. Lett. pmid:24828482
Tricarico PM et al. Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. 2014 Int J Mol Sci pmid:24758928
Piłsyk S et al. Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. 2014 Gene pmid:24793581
Yeganeh B et al. Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. 2014 Pharmacol. Ther. pmid:24582968
Rojo-Arreola L et al. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. 2014 PLoS ONE pmid:24489942
Li J et al. De novo synthesis of steroids and oxysterols in adipocytes. 2014 J. Biol. Chem. pmid:24280213
Vannice JC et al. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. 2014 J. Bacteriol. pmid:24375100
Wang Z et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24367099
Sánchez-Solana B et al. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. 2014 Biochim. Biophys. Acta pmid:24286864
González-Caballero N et al. Expression of the mevalonate pathway enzymes in the Lutzomyia longipalpis (Diptera: Psychodidae) sex pheromone gland demonstrated by an integrated proteomic approach. 2014 J Proteomics pmid:24185139
Pampalakis G et al. The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. 2014 Oncotarget pmid:24158494
Bentley FK et al. Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. 2014 Mol Plant pmid:24157609
Zelcer N et al. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. 2014 Mol. Cell. Biol. pmid:24449766
Kiser PD et al. Chemistry of the retinoid (visual) cycle. 2014 Chem. Rev. pmid:23905688
Rachner TD et al. Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. 2014 Breast Cancer Res. pmid:24528599
Tyurin M Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. 2013 J. Ind. Microbiol. Biotechnol. pmid:23649912
Ramak P et al. Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. 2013 J. Plant Physiol. pmid:23611428
Chang WC et al. Current development in isoprenoid precursor biosynthesis and regulation. 2013 Curr Opin Chem Biol pmid:23891475
Polidoro S et al. Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. 2013 Mutat. Res. pmid:23892139
Santolaria T et al. Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. 2013 J. Immunol. pmid:23836057