Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Liu JC et al. The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. 2002 Am. J. Chin. Med. pmid:12568290
pmid:12605351
Masamura K et al. Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615662
De-Eknamkul W and Potduang B Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. 2003 Phytochemistry pmid:12620352
Righetti M et al. The in vitro metabolism of mevalonate by sterol and non-sterol pathways. 1976 J. Biol. Chem. pmid:1262340
Aktas O et al. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. 2003 J. Exp. Med. pmid:12629065
Laufs U Beyond lipid-lowering: effects of statins on endothelial nitric oxide. 2003 Eur. J. Clin. Pharmacol. pmid:12634978
pmid:12636409
Poirier J Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. 2003 Trends Mol Med pmid:12657430
Abernethy D et al. In vitro inhibition of rat liver cholest-5en-3 beta-ol (cholesterol) biosynthesis by non-mercurial sulfhydryl reagents. 1976 Steroids pmid:1265795
Itoh D et al. Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. 2003 J. Nat. Prod. pmid:12662088
Luan Z et al. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12663370
Awad AB et al. Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. 2003 J. Nutr. Biochem. pmid:12667603
Holstein SA and Hohl RJ Monoterpene regulation of Ras and Ras-related protein expression. 2003 J. Lipid Res. pmid:12671036
pmid:12677167
pmid:12677170
Suzuki K Effects of S-8527 (1,1-bis(4'-(1'-carboxy-1'-methylpropoxy)phenyl) cyclohexane), a new hypolipidemic compound, on cholesterol and lipoprotein metabolism in rats. 1976 Biochem. Pharmacol. pmid:1267828
pmid:12693933
Grabińska K and Palamarczyk G Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. 2002 FEMS Yeast Res. pmid:12702274
Hemmerlin A et al. Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. 2003 J. Biol. Chem. pmid:12736259
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232
Haslinger B et al. Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. 2003 Kidney Int. pmid:12753293
pmid:12773152
pmid:12778056
Hong SB et al. Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. 2003 May-Jun Biotechnol. Prog. pmid:12790690
pmid:12792788
pmid:12796698
pmid:12798327
Silber JR et al. The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. 1992 Biochem. J. pmid:1281982
Hall FC Put your heart into the joint benefits of statins! 2003 Arthritis Res. Ther. pmid:12823851
Zheng YH et al. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12824470
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Vamvakopoulos JE and Green C HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. 2003 BMC Cardiovasc Disord pmid:12871602
pmid:12872277
Töyräs A et al. Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. 2003 Eur J Pharm Sci pmid:12885386
Laufs U and Liao JK Isoprenoid metabolism and the pleiotropic effects of statins. 2003 Curr Atheroscler Rep pmid:12911847
Bank I et al. Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen. 2003 Cell. Immunol. pmid:12914756
pmid:12914758
Ohashi K et al. Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. 2003 J. Biol. Chem. pmid:12920113
Meyers CD et al. Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. 2003 J. Lipid Res. pmid:12923222
Monick MM et al. Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. 2003 J. Immunol. pmid:12928415
pmid:12941308
Blanco-Colio LM et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes. 2003 Circulation pmid:12952848
pmid:12953163
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
pmid:12957384
Shi J et al. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. 2003 Blood Coagul. Fibrinolysis pmid:12960612
pmid:12963986
Shiota Y et al. Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. 2003 J. Biochem. pmid:12966067
pmid:12969437
pmid:1308625
Bokoch GM and Prossnitz V Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. 1992 J. Clin. Invest. pmid:1310693
Khosravi-Far R et al. Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct. 1992 J. Biol. Chem. pmid:1332953
HONG L and WRIGHT LD Paper chromatography of mevalonate and acetate. 1957 Biochim. Biophys. Acta pmid:13479486
Buchwald H Cholesterol inhibition, cancer, and chemotherapy. 1992 Lancet pmid:1349377
pmid:1353519
Sunazuka T et al. Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase. 1992 J. Antibiot. pmid:1355474
PARK RB and BONNER J Enzymatic synthesis of rubber from mevalonic acid. 1958 J. Biol. Chem. pmid:13563498
GOODWIN TW Studies in carotenogenesis. 25. The incorporation of 14CO2, [2-14C] acetate and [2-14C]mevalonate into beta-carotene by illuminated etiolated maize seedings. 1958 Biochem. J. pmid:13607416
MARKLEY K and GURIN S Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. 1959 Biochim. Biophys. Acta pmid:13628647
GOSSELIN L and POPJAK G Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid. 1959 Biochem. J. pmid:13651113
PURCELL AE et al. The incorporation of mevalonic acid into tomato carotenoids. 1959 J. Biol. Chem. pmid:13654323
RILLING HC and BLOCH K On the mechanism of squaiene biogenesis from mevalonic acid. 1959 J. Biol. Chem. pmid:13654391
pmid:13727607
POPJAK G et al. Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. 1961 J. Biol. Chem. pmid:13737104
pmid:13739420
SCHLESINGER MJ and COON MJ Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver. 1961 J. Biol. Chem. pmid:13747804
SHAH SN et al. The effect of growth hormone administration and dietary protein on the incorporation of sodium acetate-2-C14 and mevalonic acid-2-C14 into liver cholesterol. 1961 Arch. Biochem. Biophys. pmid:13750592
TADA M and LYNEN F [On the biosynthesis of terpenes. XIV. On the determination of phosphomevalonic acid kinase and pyrophosphomevalonic acid decarboxylase in cell extracts]. 1961 J. Biochem. pmid:13774769
Schafer BL et al. Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria. 1992 J. Biol. Chem. pmid:1377680
pmid:13793365
BLOCH K et al. Mevalonic acid pyrophosphate and isopentenylpyrophosphate. 1959 J. Biol. Chem. pmid:13801508
DE WAARD A and POPJAK G Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations. 1959 Biochem. J. pmid:13815126
DURR IF and RUDNEY H The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. 1960 J. Biol. Chem. pmid:13818862
ELWOOD JC et al. Lipid metabolism in the diabetic rat. IV. Metabolism of acetate, acetoacetate, butyrate, and mevalonate in vitro. 1960 J. Biol. Chem. pmid:13820133
GARATTINI S et al. Lipid biosynthesis in vivo from acetate-1-C 14 and 2-C 14 and mevalonic-2-C 14 acid. 1959 Arch. Biochem. Biophys. pmid:13826357
WITTING LA and PORTER JW Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. 1959 J. Biol. Chem. pmid:13845505
BRAITHWAITE GD and GOODWIN TW Studies in carotenogenesis. 26. The incorporation of [C14] acetate, [C14] mevalonate and C14-labelled carbon dioxide into beta-carotene by the fungus Phycomyces blakesleeanus. 1960 Biochem. J. pmid:13849152
BRAITHWAITE GD and GOODWIN TW Studies in carotenogenesis. 27. Incorporation of [2-14C] acetate, DL-[2-14C] mevalonate and C14-labelled carbon dioxide into carrotroot preparations. 1960 Biochem. J. pmid:13849153
NICHOLAS HJ and THOMAS BE Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. 1959 Biochim. Biophys. Acta pmid:13854106
pmid:13874154
Manzi P et al. Seasonal commitment of HMGCoA reductase activity to vitellogenin production. 1992 Biosci. Rep. pmid:1391685
pmid:13921034
pmid:13921035
pmid:13921036
OHNOKI D et al. D5-Phosphomevalonic acid as the intermediate of the enzymatic synthesis of bacterial phytoene. 1962 J. Biochem. pmid:13939688
GAYLOR JL Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. 1963 Arch. Biochem. Biophys. pmid:13946925
GOODMAN DS et al. Studies of cholesterol biosynthesis. V. The time course and pathway of the later stages of cholesterol biosynthesis in the livers of intact rats. 1963 J. Biol. Chem. pmid:13949089
FUMAGALLI R et al. Cholesterol synthesis in rat brain: differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14. 1962 Arch. Biochem. Biophys. pmid:13960261
BEELER DA et al. The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. 1963 Arch. Biochem. Biophys. pmid:13970235
pmid:13970858
Adamson P et al. Post-translational modifications of p21rho proteins. 1992 J. Biol. Chem. pmid:1400319
pmid:14011505
BRODIE JD et al. The participation of malonyl coenzyme A in the biosynthesis of mevalonic acid. 1963 J. Biol. Chem. pmid:14015675
RAMASARMA T and RAMAKRISHNAN T Incorporation of [2-14C]mevalonic acid and [2-14C]acetic acid into lipids of mycobacteria. 1961 Biochem. J. pmid:14038591
pmid:14039712
pmid:14065977
PORTMAN OW and SUGANO M THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. 1963 Arch. Biochem. Biophys. pmid:14072510
DALY MM et al. CHOLESTEROL CONCENTRATION AND CHOLESTEROL SYNTHESIS IN AORTAS OF RATS WITH RENAL HYPERTENSION. 1963 J. Clin. Invest. pmid:14074354
TERNER C and KORSH G THE BIOSYNTHESIS OF GLYCERIDES IN HOMOGENATES OF NORMAL LACTATING MAMMARY GLAND AND OF MAMMARY TUMOR TISSUE OF THE MOUSE. 1963 Cancer Res. pmid:14079150