Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
BEHER WT et al. TIME COURSE OF FECAL STEROID-C14 EXCRETION IN VARIOUS RODENTS. 1963 Am. J. Physiol. pmid:14084977
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pmid:14110701
Edwards PA et al. Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo. 1977 J. Biol. Chem. pmid:14128
MEROLA AJ and ARNOLD A ESTRONE INHIBITION OF CHOLESTEROL BIOSYNTHESIS AT THE MEVALONIC ACID STAGE. 1964 Science pmid:14169718
pmid:14171025
TSAI SC et al. TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. 1964 Arch. Biochem. Biophys. pmid:14186739
BRODIE JD et al. ENZYME-BOUND INTERMEDIATES IN THE BIOSYNTHESIS OF MEVALONIC AND PALMITIC AICDS. 1964 J. Biol. Chem. pmid:14189864
Khosravi-Far R et al. Protein prenylation: key to ras function and cancer intervention? 1992 Cell Growth Differ. pmid:1419908
DURR IF and SHWAYRI AN METABOLISM OF MEVALONIC ACID BY LACTOBACILLUS PLANTARUM. 1964 J. Bacteriol. pmid:14203352
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN THE RABBIT AND GUINEA PIG. 1964 J. Biol. Chem. pmid:14213342
GOODMAN DS and SHIRATORI T IN VIVO TURNOVER OF DIFFERENT CHOLESTEROL ESTERS IN RAT LIVER AND PLASMA. 1964 J. Lipid Res. pmid:14221103
GOODMAN DS THE IN VIVO TURNOVER OF INDIVIDUAL CHOLESTEROL ESTERS IN HUMAN PLASMA LIPOPROTEINS. 1964 J. Clin. Invest. pmid:14223916
SUGANO M and PORTMAN OW FATTY ACID SPECIFICITIES AND RATES OF CHOLESTEROL ESTERIFICATION IN VIVO AND IN VITRO. 1964 Arch. Biochem. Biophys. pmid:14224844
pmid:14236635
pmid:14236647
FIMOGNARI GM and RODWELL VW CHOLESTEROL BIOSYNTHESIS: MEVALONATE SYNTHESIS INHIBITED BY BILE SALTS. 1965 Science pmid:14245778
AARONSON S A ROLE FOR A STEROL AND A STEROL PRECURSOR IN THE BACTERIUM RHODOPSEUDOMONAS PALUSTRIS. 1964 J. Gen. Microbiol. pmid:14247747
BAILEY JM LIPID METABOLISM IN CULTURED CELLS. 3. CHOLESTEROL EXCRETION PROCESS. 1964 Am. J. Physiol. pmid:14251922
SMITH PF and HENRIKSON CV COMPARATIVE BIOSYNTHESIS OF MEVALONIC ACID BY MYCOPLASMA. 1965 J. Bacteriol. pmid:14255655
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN RAT AND GUINEA PIG LIVER IN VITRO. 1965 J. Lipid Res. pmid:14280469
KRITCHEVSKY D et al. STUDIES ON THE BIOSYNTHESIS OF LIPIDS IN THE BABOON. BIOSYNTHESIS AND TRANSPORT OF CHOLESTEROL. 1965 Clin. Chim. Acta pmid:14287064
GRAEBE JE et al. BIOSYNTHESIS OF GIBBERELLINS. I. THE BIOSYNTHESIS OF (-)-KAUREN-19-OL, AND TRANS-GERANYLGERANIOL IN ENDOSPERM NUCELLUS OF ECHINOCYSTIS MACROCARPA GREENE. 1965 J. Biol. Chem. pmid:14289357
Casey WM et al. Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae. 1992 J. Bacteriol. pmid:1429452
Overmeyer JH and Maltese WA Isoprenoid requirement for intracellular transport and processing of murine leukemia virus envelope protein. 1992 J. Biol. Chem. pmid:1429616
Kim CM et al. cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function. 1992 J. Biol. Chem. pmid:1429658
Peter M et al. Isoprenylation of rab proteins on structurally distinct cysteine motifs. 1992 J. Cell. Sci. pmid:1429897
HELLIG HR and SAVARD K BIOSYNTHESIS OF PROGESTERONE, STEROLS, AND SQUALENE FROM ACETATE-1-14-C AND MEVALONATE-2-14-C BY THE BOVINE CORPUS LUTEUM IN VITRO. 1965 J. Biol. Chem. pmid:14299614
pmid:14321865
AZARNOFF DL et al. STUDIES WITH ETHYL CHLOROPHENOXYISOBUTYRATE (CLOFIBRATE). 1965 Metab. Clin. Exp. pmid:14327272
DIPLOCK AT et al. VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. 1965 Biochem. J. pmid:14333548
GOODWIN TW and WILLIAMS RJ A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. 1965 Biochem. J. pmid:14342248
KNAUSS HJ et al. The biosynthesis of mevalonic acid from 1-C14-acetate by a rat liver enzyme system. 1959 J. Biol. Chem. pmid:14410081
NICHOLAS HJ Biosynthesis of sclareol, beta-sitosterol, and oleanolic acid from mevalonic acid-2-C-14. 1962 J. Biol. Chem. pmid:14479433
Wang CZ and Miziorko HM Methodology for synthesis and isolation of 5-phosphomevalonic acid. 2003 Anal. Biochem. pmid:14511696
pmid:14511985
pmid:14512087
Lin YL et al. Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. 2003 Virology pmid:14517078
Dubey VS et al. An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants. 2003 J. Biosci. pmid:14517367
pmid:1451989
García-Pelayo MC et al. Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. 2003 J. Cell. Biochem. pmid:14523992
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Gidez LI et al. Turnover of cholesteryl esters of plasma lipoproteins in the rat. 1967 J. Lipid Res. pmid:14564699
pmid:14572607
Ohm TG et al. Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. 2003 Pharmacopsychiatry pmid:14574625
pmid:14583185
Jones PJ et al. Correspondence between plasma mevalonic acid levels and deuterium uptake in measuring human cholesterol synthesis. 1992 Eur. J. Clin. Invest. pmid:1459177
pmid:14598891
Roitelman J and Simoni RD Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. 1992 J. Biol. Chem. pmid:1460026
Andela VB et al. The mevalonate synthesis pathway as a therapeutic target in cancer. 2003 Clin. Orthop. Relat. Res. pmid:14600593
Kaneta S et al. All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. 2003 Atherosclerosis pmid:14612203
Rodríguez JM et al. Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency. 2004 J. Biol. Chem. pmid:14612443
Dong J et al. Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. 2003 Hypertens. Res. pmid:14620928
pmid:14624137
Huang KC et al. Statins induce suppressor of cytokine signaling-3 in macrophages. 2003 FEBS Lett. pmid:14644448
Stone BG and Evans CD Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver. 1992 J. Lipid Res. pmid:1464750
Zacco A et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. 2003 J. Neurosci. pmid:14657168
Rodríguez-Concepción M et al. Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. 2004 Plant Cell pmid:14660801
Polo MP et al. Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. 2003 Biochem. Cell Biol. pmid:14663504
pmid:14678236
Ruiz-Velasco N et al. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. 2004 Biochem. Pharmacol. pmid:14698043
Tringali G et al. Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. 2004 Neurosci. Lett. pmid:14698450
Peña-Diaz J et al. Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae. 2004 Mol. Biol. Cell pmid:14699057
Saijonmaa O et al. Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14704227
Sauane M et al. Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. 2004 Biochem. Biophys. Res. Commun. pmid:14706631
Raupp P et al. Novel genotype of mevalonic aciduria with fatalities in premature siblings. 2004 Arch. Dis. Child. Fetal Neonatal Ed. pmid:14711867
Kasahara H et al. Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. 2004 J. Biol. Chem. pmid:14726522
Pallottini V et al. Age-related changes of isoprenoid biosynthesis in rat liver and brain. 2003 Biogerontology pmid:14739708
Bate C et al. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. 2004 J. Biol. Chem. pmid:14754889
Turunen M et al. Metabolism and function of coenzyme Q. 2004 Biochim. Biophys. Acta pmid:14757233
Kawasaki T et al. A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. 2003 J. Antibiot. pmid:14763562
Hedl M and Rodwell VW Enterococcus faecalis mevalonate kinase. 2004 Protein Sci. pmid:14767074
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
Larsson O and Wejde J Dolichol delays G1-arrest for one cell cycle in human fibroblasts subjected to depletion of serum or mevalonate. 1992 J. Cell. Sci. pmid:1487489
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282
Thompson K and Rogers MJ Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. 2004 J. Bone Miner. Res. pmid:14969398
pmid:14985071
Fuse M et al. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. 2004 Biochem. Biophys. Res. Commun. pmid:14985133
Barkley SJ et al. Identification of an Archaeal type II isopentenyl diphosphate isomerase in methanothermobacter thermautotrophicus. 2004 J. Bacteriol. pmid:14996812
pmid:1499946
Begley M et al. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. 2004 FEBS Lett. pmid:15013758
pmid:15021918
Hedl M et al. Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases. 2004 J. Bacteriol. pmid:15028676
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
pmid:15034683
pmid:15035434
pmid:15037710
pmid:15038955
Mikulski SM et al. Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. 1992 Br. J. Cancer pmid:1503903
Tokoro T et al. The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). 2004 Yakugaku Zasshi pmid:15049129
Reichart B et al. Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. 2004 BMC Cell Biol. pmid:15053843
Blanco-Colio LM et al. Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. 2004 J. Am. Coll. Cardiol. pmid:15063428
Boucher Y et al. Origins and evolution of isoprenoid lipid biosynthesis in archaea. 2004 Mol. Microbiol. pmid:15066037
pmid:15076215
Andela VB Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62:6015-20. 2004 Cancer Res. pmid:15087415
Cenedella RJ et al. Cholesterylene, a newly recognized tissue lipid, found at high levels in the cornea. 1992 Biochem. Biophys. Res. Commun. pmid:1510688
pmid:15110690
pmid:15116060
Danesh FR and Kanwar YS Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. 2004 FASEB J. pmid:15117885
Kuzuyama T et al. Heterologous mevalonate production in Streptomyces lividans TK23. 2004 Biosci. Biotechnol. Biochem. pmid:15118326