Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
Morrone D et al. Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. 2010 Appl. Microbiol. Biotechnol. pmid:19777230
Fukunaga M et al. Mast cell death induced by 24(S),25-epoxycholesterol. 2010 Exp. Cell Res. pmid:20854813
Honour JW Steroid assays in paediatric endocrinology. 2010 J Clin Res Pediatr Endocrinol pmid:21274330
Head BP et al. Loss of caveolin-1 accelerates neurodegeneration and aging. 2010 PLoS ONE pmid:21203469
Zheng Z et al. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. 2010 Diabetes pmid:20566666
Liu Q et al. Dynamics of lamin-A processing following precursor accumulation. 2010 PLoS ONE pmid:20526372
Aoyama T et al. Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. 2010 Biol. Pharm. Bull. pmid:20522984
Jameson JM et al. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. 2010 Cell. Immunol. pmid:20483407
Hughes M et al. Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. 2010 J. Neurochem. pmid:20477946
Targett-Adams P et al. Lipid metabolism and HCV infection. 2010 Viruses pmid:21994676
Snoeren TA et al. The herbivore-induced plant volatile methyl salicylate negatively affects attraction of the parasitoid Diadegma semiclausum. 2010 J. Chem. Ecol. pmid:20407809
Lefurgy ST et al. Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. 2010 J. Biol. Chem. pmid:20404339
Clendening JW et al. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. 2010 Blood pmid:20360469
Delang L et al. Antiviral therapy for hepatitis C virus: beyond the standard of care. 2010 Viruses pmid:21994657
Yang Z et al. Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. 2010 Int. J. Cancer pmid:19626588
De Leo L et al. Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. 2010 Pharmacol. Res. pmid:20206266
Tisch D and Schmoll M Light regulation of metabolic pathways in fungi. 2010 Appl. Microbiol. Biotechnol. pmid:19915832
Coscia M et al. Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. 2010 J. Cell. Mol. Med. pmid:19818098
Kojima Y et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. 2010 Cardiovasc. Res. pmid:20045866
Kones R Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. 2010 Drug Des Devel Ther pmid:21267417
Hooff GP et al. Isoprenoids, small GTPases and Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20382260
Mitrofan LM et al. Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. 2010 J. Biol. Chem. pmid:19875454
Rossi J et al. Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. 2010 Eur. J. Pharmacol. pmid:20863785
Kaneda T et al. Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. 2010 Eur. J. Pharmacol. pmid:20851116
Kassan M et al. In vitro antioxidant activity of pravastatin provides vascular protection. 2010 Eur. J. Pharmacol. pmid:20044990
Kocsis GF et al. Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. 2010 Med. Sci. Monit. pmid:20037483
Endo A A historical perspective on the discovery of statins. 2010 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:20467214
Clendening JW et al. Dysregulation of the mevalonate pathway promotes transformation. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20696928
Rico J et al. Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. 2010 Appl. Environ. Microbiol. pmid:20675444
Okamura E et al. Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20534558
Chen CC et al. Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. 2010 J. Appl. Physiol. pmid:20466804
Norman KL and Sarnow P Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. 2010 J. Virol. pmid:19846523
Hooff GP et al. Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. 2010 Mol. Neurobiol. pmid:20405344
Jiang XS et al. Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. 2010 Mol. Cell Proteomics pmid:20305089
Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
Asadollahi MA et al. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. 2010 Biotechnol. Bioeng. pmid:20091767
Lee SK et al. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. 2010 Biochem. Biophys. Res. Commun. pmid:20043868
Huang M et al. Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. 2010 Plant Physiol. pmid:20463089
Rydgren T and Sandler S The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. 2009 Biochem. Biophys. Res. Commun. pmid:19150339
Yoon HE and Yang CW Established and newly proposed mechanisms of chronic cyclosporine nephropathy. 2009 Korean J. Intern. Med. pmid:19543484
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Anthony JR et al. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. 2009 Metab. Eng. pmid:18775787
Lorenzen W et al. Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. 2009 J. Bacteriol. pmid:19617362
Zhao S et al. Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. 2009 Bioorg. Med. Chem. pmid:19879766
Domoki F et al. Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. 2009 Am. J. Physiol., Cell Physiol. pmid:18971391
Xu Q et al. Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. 2009 BMC Genomics pmid:19922663
Rothwell C et al. Cholesterol biosynthesis modulation regulates dengue viral replication. 2009 Virology pmid:19419745
Ledezma E et al. Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. 2009 Melanoma Res. pmid:19276863
Maeda T and Horiuchi N Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. 2009 J. Biochem. pmid:19254925
Dje N'Guessan P et al. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19122173
Iriti M and Faoro F Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. 2009 Int J Mol Sci pmid:20111684
Jawaid S et al. Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). 2009 PLoS ONE pmid:20011597
Raemer PC et al. Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. 2009 Eur. J. Immunol. pmid:19424968
Chang PK et al. Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. 2009 Toxins (Basel) pmid:22069533
Kirmizis D and Chatzidimitriou D Pleiotropic vasoprotective effects of statins: the chicken or the egg? 2009 Drug Des Devel Ther pmid:19920934
Eldor R and Raz I American Diabetes Association indications for statins in diabetes: is there evidence? 2009 Diabetes Care pmid:19875586
Massonnet B et al. Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. 2009 Eur. Cytokine Netw. pmid:19825520
Wang W et al. Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. 2009 BMC Genomics pmid:19818120
Brahmachari S et al. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. 2009 J. Immunol. pmid:19812204
de Souza W and Rodrigues JC Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. 2009 Interdiscip Perspect Infect Dis pmid:19680554
Zeki AA et al. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. 2009 Am. J. Respir. Crit. Care Med. pmid:19608720
Minichsdorfer C and Hohenegger M Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. 2009 Br. J. Pharmacol. pmid:19563533
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Montoya CJ et al. Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. 2009 Trials pmid:19538732
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Balibar CJ et al. The mevalonate pathway of Staphylococcus aureus. 2009 J. Bacteriol. pmid:19028897
Khan MA et al. Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. 2009 J. Immunol. pmid:19342651
Alvarez Y et al. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. 2009 J. Pharmacol. Exp. Ther. pmid:19318593
Niessen J et al. Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. 2009 Drug Metab. Dispos. pmid:19237515
Lachmann HJ and Hawkins PN Developments in the scientific and clinical understanding of autoinflammatory disorders. 2009 Arthritis Res. Ther. pmid:19232070
Kim WY et al. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. 2009 J. Neurochem. pmid:19209406
Zeiser R et al. Regulation of different inflammatory diseases by impacting the mevalonate pathway. 2009 Immunology pmid:19191903
Yeger-Lotem E et al. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. 2009 Nat. Genet. pmid:19234470
Knight LA et al. Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. 2009 BMC Cancer pmid:19175937
Deshpande G et al. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. 2009 PLoS Genet. pmid:19132091
Mansouri H et al. Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. 2009 J Integr Plant Biol pmid:19522814
Monzack EL et al. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19023089
Xiang Z and Reeves SA Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. 2009 Exp. Neurol. pmid:18929563
Olson AL et al. Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. 2009 Proteins pmid:18798562
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Dueber JE et al. Synthetic protein scaffolds provide modular control over metabolic flux. 2009 Nat. Biotechnol. pmid:19648908
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Tsuruta H et al. High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. 2009 PLoS ONE pmid:19221601
Fujimoto M et al. Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. 2009 Eur. J. Pharmacol. pmid:19059394
Sun X et al. Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. 2009 Bioresour. Technol. pmid:19386490
Sidorkiewicz M et al. Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. 2009 Virus Res. pmid:19540284
Bełtowski J et al. Adverse effects of statins - mechanisms and consequences. 2009 Curr Drug Saf pmid:19534648
García I et al. QSAR and complex network study of the chiral HMGR inhibitor structural diversity. 2009 Bioorg. Med. Chem. pmid:19026553
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Kroll J et al. Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. 2009 Metab. Eng. pmid:19558962
Alagna F et al. Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. 2009 BMC Genomics pmid:19709400
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Grigore L et al. Combination therapy in cholesterol reduction: focus on ezetimibe and statins. 2008 Vasc Health Risk Manag pmid:18561502
Sharyo S et al. Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. 2008 Kidney Int. pmid:18509318
Okada K et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. 2008 Plant Cell Physiol. pmid:18303110
Matsuda T et al. Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. 2008 J. Pharmacol. Exp. Ther. pmid:18593956
Fried LF Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. 2008 Kidney Int. pmid:18528321
Saito A et al. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. 2008 Melanoma Res. pmid:18337644
Schwartz YSh et al. Cholesterol-induced stimulation of postinflammatory liver fibrosis. 2008 Bull. Exp. Biol. Med. pmid:19110552