Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Beale JM et al. Studies on the biosynthesis of terrecyclic acid A, an antitumor antibiotic from Aspergillus terreus. 1984 J. Antibiot. pmid:6511664
Wilson JS et al. Chronic ethanol feeding causes accumulation of serum cholesterol in rat pancreas. 1984 Exp. Mol. Pathol. pmid:6510504
Yousef IM and Tuchweber B Effect of lithocholic acid on cholesterol synthesis and transport in the rat liver. 1984 Biochim. Biophys. Acta pmid:6509080
Bergstrom JD et al. The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis. 1984 J. Biol. Chem. pmid:6501306
Harwood HJ et al. Measurement of human leukocyte microsomal HMG-CoA reductase activity. 1984 J. Lipid Res. pmid:6491541
Randolph RK et al. Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low density lipoprotein receptor pathway. 1984 J. Lipid Res. pmid:6491537
Deneris ES et al. In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction. 1984 Biochem. Biophys. Res. Commun. pmid:6487307
Aguilera JA et al. Effect of dietary cholesterol on mevalonate metabolism by sterol and nonsterol pathways. 1984 Biochem. Biophys. Res. Commun. pmid:6477574
Ekström TJ et al. Metabolic labeling of dolichol and dolichyl phosphate in isolate hepatocytes. 1984 J. Biol. Chem. pmid:6469972
Gill JF et al. Transport of mevalonate by Pseudomonas sp. strain M. 1984 J. Bacteriol. pmid:6434521
Boissonneault GA and Heiniger HJ 25-Hydroxycholesterol-induced elevation in 45Ca uptake: correlation with depressed DNA synthesis. 1984 J. Cell. Physiol. pmid:6430918
Weinstock SB et al. The shunt pathway of mevalonate metabolism in the isolated perfused rat liver. 1984 J. Biol. Chem. pmid:6430893
Wilton DC The effect of cholesterol on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis. 1983 Biochem. J. pmid:6418144
Brady PS et al. Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. 1983 J. Lipid Res. pmid:6415196
Takeuchi N et al. Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing. 1978 Exp. Gerontol. pmid:639893
Nakanishi S et al. Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. 1984 J. Biochem. pmid:6397465
Middleton B et al. A mevalonate requirement for maintenance of fatty acid and protein synthesis during hormonally stimulated development of mammary gland in vitro. 1984 J. Biol. Chem. pmid:6381480
Wood SG and Gottlieb D Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637850
Wood SG and Gottlieb D Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637849
Ryder NS et al. Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. 1984 Antimicrob. Agents Chemother. pmid:6375557
Wade DP et al. Independent regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and chylomicron remnant receptor activities in rat liver. 1984 Biochem. J. pmid:6324750
Simpkins C Thyroid hormone in biological rhythms. 1983 Med. Hypotheses pmid:6318057
Perkins SL et al. Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium. 1982 Biochim. Biophys. Acta pmid:6279167
pmid:6271066
Mitchell ED and Avigan J Control of phosphorylation and decarboxylation of mevalonic acid and its metabolites in cultured human fibroblasts and in rat liver in vivo. 1981 J. Biol. Chem. pmid:6263908
Arebalo RE et al. In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6256737
Kopito RR and Brunengraber H (R)-mevalonate excretion in human and rat urines. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6255462
Lehoux JG and Preiss B Regulation of hamster adrenal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. 1980 Endocrinology pmid:6247136
pmid:6236250
pmid:6227507
Bochenek W and Rodgers JB Effects of saturated and unsaturated fats given with and without dietary cholesterol on hepatic cholesterol synthesis and hepatic lipid metabolism. 1978 Biochim. Biophys. Acta pmid:620042
Gustafsson J and Sjöstedt S On the stereospecificity of microsomal "26"-hydroxylation in bile acid biosynthesis. 1978 J. Biol. Chem. pmid:618857
Ott DB and Lachance PA Biochemical controls of liver cholesterol biosynthesis. 1981 Am. J. Clin. Nutr. pmid:6170219
Baker FC and Schooley DA Biosynthesis of 3-hydroxy-3-methylglutaryl-CoA, 3-hydroxy-3-ethylglutaryl-CoA, mevalonate and homomevalonate by insect corpus allatum and mammalian hepatic tissues. 1981 Biochim. Biophys. Acta pmid:6166327
pmid:616293
Servouse M et al. Isolation and characterization of yeast mutants blocked in mevalonic acid formation. 1984 Biochem. Biophys. Res. Commun. pmid:6148937
Schnitzer-Polokoff R et al. Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase. 1982 J. Biol. Chem. pmid:6118375
Henze K et al. The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. 1981 Biochim. Biophys. Acta pmid:6118180
Chang TY and Limanek JS Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells. 1980 J. Biol. Chem. pmid:6105157
DeBold CR and Elwood JC Mevalonic acid analogs as inhibitors of cholesterol biosynthesis. 1981 J Pharm Sci pmid:6101142
Cohen LH et al. Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2. 1984 Biochem. J. pmid:6089762
Cuthbert JA and Lipsky PE Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6087331
Kreuz K and Kleinig H Synthesis of prenyl lipids in cells of spinach leaf. Compartmentation of enzymes for formation of isopentenyl diphosphate. 1984 Eur. J. Biochem. pmid:6086332
Capuzzi DM and Cevallos WH Inhibition of hepatic cholesterol and triglyceride synthesis by guanabenz acetate. 1984 J. Cardiovasc. Pharmacol. pmid:6084138
Diekmann H and Zähner H [Constitution and catabolism of fusigen to delta-2-anhydromevalonic acid lactone]. 1967 Eur. J. Biochem. pmid:6082611
Baisted DJ et al. The effect of cyclic triterpenes on cholesterol synthesis from mevalonate in rat liver homogenates. 1967 Biochem. Biophys. Res. Commun. pmid:6076231
Castle M et al. The mechanism of introduction of alkyl groups at C-24 of sterols. I. The precursor of the C2 group. 1967 J. Biol. Chem. pmid:6073661
Wellburn AR and Hemming FW The subcellular distribution and biosynthesis of castaprenols and plastoquinone in the leaves of Aesculus hippocastanum. 1967 Biochem. J. pmid:6068175
Auda H et al. Biosynthesis of methylcyclopentane monoterpenoids. 3. Actinidine. 1967 J. Biol. Chem. pmid:6061704
Williams RJ et al. The biosynthesis of cyclic carotenes. 1967 Biochem. J. pmid:6060456
Wieckowski S and Goodwin TW Incorporation of DL-[2-14C]mevalonic acid lactone into beta-carotene and the phytol side chain of chlorophyll in cotyledons of four species of pine seedlings. 1967 Biochem. J. pmid:6060454
Goad LJ and Goodwin TW Studies on phytosterol biosynthesis: the sterols of Larix decidua leaves. 1967 Eur. J. Biochem. pmid:6060188
Gough DP and Hemming FW The stereochemistry of betulaprenol biosynthesis. 1967 Biochem. J. pmid:6056617
Krishnaiah KV et al. Regulation of steroidogenesis by ubiquinone. 1967 Biochem. Biophys. Res. Commun. pmid:6052477
Williams RJ et al. The stereospecific biosynthesis of phytoene and polyunsaturated carotenes. 1967 Biochem. J. pmid:6049923
Rao KS and Olson RE The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. 1967 Biochim. Biophys. Acta pmid:6049507
Threlfall DR et al. Biosynthesis of the prenyl side chains of plastoquinone and related compounds in maize and barley shoots. 1967 Biochem. J. pmid:6049407
pmid:6048708
Krishnaiah KV et al. Effect of dietary cholesterol and ubiquinone on isoprene synthesis in rat liver. 1967 Arch. Biochem. Biophys. pmid:6035059
Graham JM and Green C The binding of sterols in cellular membranes. 1967 Biochem. J. pmid:6032974
Rao KS and Olson RE The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. 1967 Biochem. Biophys. Res. Commun. pmid:6030977
Nestel PJ and Monger EA Turnover of plasma esterified cholesterol in normocholesterolemic and hypercholesterolemic subjects and its relation to body build. 1967 J. Clin. Invest. pmid:6026102
pmid:6021039
Linn TC The effect of cholesterol feeding and fasting upon beta-hydroxy-beta-methylglutaryl coenzyme A reductase. 1967 J. Biol. Chem. pmid:6020446
Katsuki H and Bloch K Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. 1967 J. Biol. Chem. pmid:6016607
pmid:598576
Chesterton CJ The subcellular site of cholesterol synthesis in rat liver. 1966 Biochem. Biophys. Res. Commun. pmid:5971766
Ockner RK and Laster L Biosynthesis of delta-7-cholesten-3-beta-ol, delta-5,7-cholestadien-3-beta-ol, and delta-5-cholesten-3-beta-ol by guinea pig intestinal mucosa in vitro. 1966 J. Lipid Res. pmid:5971571
Gould RG and Swyryd EA Sites of control of hepatic cholesterol biosynthesis. 1966 J. Lipid Res. pmid:5971049
Von Holt C et al. Metabolic effects of hypoglycin and methylenecyclopropaneacetic acid. 1966 Biochim. Biophys. Acta pmid:5968584
Rogers LJ et al. Mevalonate-kinase isoenzymes in plant cells. 1966 Biochem. J. pmid:5968528
Nestel PJ and Couzens EA Turnover of individual cholesterol esters in human liver and plasma. 1966 J. Clin. Invest. pmid:5967699
Williams RJ et al. A possible mechanism for the biosynthesis of eschscholtzxanthin. 1966 Biochim. Biophys. Acta pmid:5966716
Paoletti P et al. Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. 1966 Neurochirurgia (Stuttg) pmid:5966653
Treharne KJ et al. Incorporation of [14C] carbon dioxide and [2-14C] mevalonic acid into terpenoids of higher plants during chloroplast development. 1966 Biochem. J. pmid:5965341
Thorne KJ and Kodicek E The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid. 1966 Biochem. J. pmid:5965329
Goad LJ and Goodwin TW The biosynthesis of sterols in higher plants. 1966 Biochem. J. pmid:5964970
Rees HH et al. The stereospecific biosynthesis of plant sterols and alpha- and beta-amyrin. 1966 Biochem. J. pmid:5964969
pmid:5956125
Rogers LJ et al. Intracellular localization of mevalonate-activating enzymes in plant cells. 1966 Biochem. J. pmid:5947149
Butterworth PH et al. In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. 1966 Arch. Biochem. Biophys. pmid:5944963
Carrol JJ and Pritham GH Effects of sex hormones and of potassium salts of fatty acids on the biosynthesis in vitro of cholesterol from [2-14C]mevalonic acid. 1966 Biochim. Biophys. Acta pmid:5943435
pmid:5943433
pmid:5930574
Ogilvie JW and Kaplan BH The inhibition of sterol biosynthesis in rat liver homogenates by bile. 1966 J. Biol. Chem. pmid:5926178
Gold PH and Olson RE Studies on coenzyme Q. The biosynthesis of coenzyme Q9 in rat tissue slices. 1966 J. Biol. Chem. pmid:5919683
Siperstein MD and Fagan VM Feedback control of mevalonate synthesis by dietary cholesterol. 1966 J. Biol. Chem. pmid:5908125
Siperstein MD et al. A gas-liquid chromatographic procedure for the measurement of mevalonic acid synthesis. 1966 J. Biol. Chem. pmid:5908124
Gans JH Epinephrine and cholesterol metabolism in the dog. Hepatic metabolism of pyruvate and mevalonate in vitro. 1966 J. Pharmacol. Exp. Ther. pmid:5902173
Goodwin TW and Williams RJ A mechanism for the biosynthesis of alpha-carotene. 1965 Biochem. J. pmid:5881648
Mitropoulos KA and Myant NB Evidence that the oxidation of the side chain of cholesterol by liver mitochondria is stereospecific, and that the immediate product of cleavage is propionate. 1965 Biochem. J. pmid:5881647
Williamson IP and Kekwick RG The formation of 5-phosphomevalonate by mevalonate kinase in Hevea brasiliensis latex. 1965 Biochem. J. pmid:5862423
Teal SW and Gamble W Effect of p-chlorophenoxyisobutyric acid, ethyl p-chlorophenoxyisobutyrate, and Atromid on the synthesis of nonsaponifiable material and cholesterol in the bovine aorta. 1965 Biochem. Pharmacol. pmid:5840738
pmid:5840681
Joshi VC et al. Biosynthetic relationship between ubichromenol and ubiquinone. 1964 Biochem. J. pmid:5838088
Malathi P and Ganguly J Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. 1964 Biochem. J. pmid:5837438
Zylber J et al. [On the biosynthesis of the piloquinone, o-phenanthrene-quinone produced by Streptomyces pilosus]. 1969 Eur. J. Biochem. pmid:5823104
Robinson DR and Ryback G Incorporation of tritium from [(4R)-4-3H]mevalonate into abscisic acid. 1969 Biochem. J. pmid:5821014
Gautheron C et al. Synthesis of cholesterolinto the central nervous system and its radioautographic localization. 1969 Exp. Neurol. pmid:5811720
Back P et al. Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids. 1969 Arch. Biochem. Biophys. pmid:5810824