Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Aliferis KA and Jabaji S FT-ICR/MS and GC-EI/MS metabolomics networking unravels global potato sprout's responses to Rhizoctonia solani infection. 2012 PLoS ONE pmid:22880040
Zaidi N et al. ATP-citrate lyase: a key player in cancer metabolism. 2012 Cancer Res. pmid:22787121
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Shi Z and Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22396595
Li X et al. Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains. 2012 Genet. Sel. Evol. pmid:22682430
Panicker SP et al. Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia. 2012 PLoS ONE pmid:22685570
Nürenberg G and Volmer DA The analytical determination of isoprenoid intermediates from the mevalonate pathway. 2012 Anal Bioanal Chem pmid:21789486
Ohsawa M et al. Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice. 2012 J. Pharmacol. Sci. pmid:22510521
Chow KS et al. Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. 2012 J. Exp. Bot. pmid:22162870
Reiniers MJ et al. 2',7'-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. 2012 J. Hepatol. pmid:22127279
Plée-Gautier E et al. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. 2012 Biochem. Pharmacol. pmid:22634049
Yokota K et al. Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb Clin. Exp. Rheumatol. pmid:21345291
Huang SH et al. Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. 2011 PLoS ONE pmid:21966365
Singh NK et al. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. 2011 Blood pmid:21841162
Yu F et al. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. 2011 Cell. Mol. Life Sci. pmid:20730551
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Tijerino A et al. Overexpression of the Trichoderma brevicompactum tri5 gene: effect on the expression of the trichodermin biosynthetic genes and on tomato seedlings. 2011 Toxins (Basel) pmid:22069764
Wang H et al. Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. 2011 J. Immunol. pmid:22013129
Ali OF et al. Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. 2011 Respir. Res. pmid:21999923
Bergman P et al. Studies on the antibacterial effects of statins--in vitro and in vivo. 2011 PLoS ONE pmid:21912631
Katuru R et al. Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21540247
Waldron J and Webster C Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. 2011 Ann. Clin. Biochem. pmid:21355014
Jeon JG et al. Natural products in caries research: current (limited) knowledge, challenges and future perspective. 2011 Caries Res. pmid:21576957
Scheller EL et al. Bisphosphonates inhibit expression of p63 by oral keratinocytes. 2011 J. Dent. Res. pmid:21551338
Kishi T Mevalonate pathway is a novel target for hypertension. 2011 Circ. J. pmid:21532185
Sakamoto K et al. Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. 2011 BMC Musculoskelet Disord pmid:21524281
Han J et al. Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. 2011 Circ. J. pmid:21467659
Siddals KW et al. Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. 2011 J. Biol. Chem. pmid:21454560
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Mongélard G et al. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. 2011 Plant Cell Environ. pmid:21443577
Zhang B et al. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. 2011 Biochemistry pmid:21438569
Kim RH et al. Bisphosphonates induce senescence in normal human oral keratinocytes. 2011 J. Dent. Res. pmid:21427353
Kyathanahalli CN and Kowluru A A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. 2011 Biochem. Pharmacol. pmid:21406184
Tsubaki M et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. 2011 Cytokine pmid:21292498
Kim KH et al. Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. 2011 Drug Metab. Dispos. pmid:20962060
Miziorko HM Enzymes of the mevalonate pathway of isoprenoid biosynthesis. 2011 Arch. Biochem. Biophys. pmid:20932952
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Nilsson S et al. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. 2011 Cancer Lett. pmid:21356574
Liu Q et al. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. 2011 PLoS ONE pmid:21858047
Lin Y et al. Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. 2011 Evid Based Complement Alternat Med pmid:19228775
Sakai H and Heike T [Hyperimmunoglobulinemia D and periodic fever syndrome]. 2011 Nihon Rinsho Meneki Gakkai Kaishi pmid:22041426
Issat T et al. Antitumor effects of the combination of cholesterol reducing drugs. 2011 Oncol. Rep. pmid:21491092
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Duke SO and Dayan FE Modes of action of microbially-produced phytotoxins. 2011 Toxins (Basel) pmid:22069756
Musso A et al. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. 2011 Haematologica pmid:20884711
Schaafsma D et al. Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. 2011 Respir. Res. pmid:21864337
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959
Barta ML et al. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. 2011 J. Biol. Chem. pmid:21561869
Yanae M et al. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. 2011 J. Exp. Clin. Cancer Res. pmid:21831290