| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shi J et al. | Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. | 2003 | Blood Coagul. Fibrinolysis | pmid:12960612 |
| Laufs U | Beyond lipid-lowering: effects of statins on endothelial nitric oxide. | 2003 | Eur. J. Clin. Pharmacol. | pmid:12634978 |
| Awad AB et al. | Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. | 2003 | J. Nutr. Biochem. | pmid:12667603 |
| Kreck M et al. | Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols. | 2003 | J. Agric. Food Chem. | pmid:12517111 |
| Wang CZ and Miziorko HM | Methodology for synthesis and isolation of 5-phosphomevalonic acid. | 2003 | Anal. Biochem. | pmid:14511696 |
| Andela VB et al. | The mevalonate synthesis pathway as a therapeutic target in cancer. | 2003 | Clin. Orthop. Relat. Res. | pmid:14600593 |
| Ohashi K et al. | Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. | 2003 | J. Biol. Chem. | pmid:12920113 |
| Shiota Y et al. | Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. | 2003 | J. Biochem. | pmid:12966067 |
| Haslinger B et al. | Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. | 2003 | Kidney Int. | pmid:12753293 |
| Meyers CD et al. | Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. | 2003 | J. Lipid Res. | pmid:12923222 |
| Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
| Zacco A et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. | 2003 | J. Neurosci. | pmid:14657168 |
| Polo MP et al. | Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. | 2003 | Biochem. Cell Biol. | pmid:14663504 |
| Itoh D et al. | Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. | 2003 | J. Nat. Prod. | pmid:12662088 |
| Kaneta S et al. | All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. | 2003 | Atherosclerosis | pmid:14612203 |
| Huang KC et al. | Statins induce suppressor of cytokine signaling-3 in macrophages. | 2003 | FEBS Lett. | pmid:14644448 |
| GarcÃa-Pelayo MC et al. | Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. | 2003 | J. Cell. Biochem. | pmid:14523992 |
| Shimada Y et al. | Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. | 2003 | Plant Physiol. | pmid:12529536 |
| Lin YL et al. | Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. | 2003 | Virology | pmid:14517078 |
| Pallottini V et al. | Age-related changes of isoprenoid biosynthesis in rat liver and brain. | 2003 | Biogerontology | pmid:14739708 |
| Giricz Z et al. | Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. | 2003 | Basic Res. Cardiol. | pmid:12955403 |
| Iguchi T et al. | Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | 2003 | Cell. Signal. | pmid:12742232 |
| Ohm TG et al. | Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. | 2003 | Pharmacopsychiatry | pmid:14574625 |
| Aktas O et al. | Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. | 2003 | J. Exp. Med. | pmid:12629065 |
| Gober HJ et al. | Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. | 2003 | J. Exp. Med. | pmid:12538656 |
| Peffley DM and Gayen AK | Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. | 2003 | J. Nutr. | pmid:12514264 |
| Houten SM et al. | Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. | 2003 | Cell. Mol. Life Sci. | pmid:12861380 |
| Poirier J | Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. | 2003 | Trends Mol Med | pmid:12657430 |
| Kawasaki T et al. | A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. | 2003 | J. Antibiot. | pmid:14763562 |
| Sever N et al. | Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. | 2003 | J. Biol. Chem. | pmid:14563840 |
| De-Eknamkul W and Potduang B | Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. | 2003 | Phytochemistry | pmid:12620352 |
| Dong J et al. | Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. | 2003 | Hypertens. Res. | pmid:14620928 |
| Dubey VS et al. | An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants. | 2003 | J. Biosci. | pmid:14517367 |
| Blanco-Colio LM et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes. | 2003 | Circulation | pmid:12952848 |
| Monick MM et al. | Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. | 2003 | J. Immunol. | pmid:12928415 |
| Laufs U and Liao JK | Isoprenoid metabolism and the pleiotropic effects of statins. | 2003 | Curr Atheroscler Rep | pmid:12911847 |
| Vamvakopoulos JE and Green C | HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. | 2003 | BMC Cardiovasc Disord | pmid:12871602 |
| Hall FC | Put your heart into the joint benefits of statins! | 2003 | Arthritis Res. Ther. | pmid:12823851 |
| Hemmerlin A et al. | Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. | 2003 | J. Biol. Chem. | pmid:12736259 |
| Sever N et al. | Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. | 2003 | Mol. Cell | pmid:12535518 |
| Zheng YH et al. | Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12824470 |
| Choi M et al. | Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. | 2003 | Kidney Int. | pmid:12472772 |
| Dimitroulakos J et al. | Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. | 2002 Jul-Aug | Neoplasia | pmid:12082550 |
| Wang W et al. | Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines. | 2002 | FEBS Lett. | pmid:12435585 |
| Mason JC et al. | Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. | 2002 | Circ. Res. | pmid:12386146 |
| RodrÃguez-Concepción M and Boronat A | Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. | 2002 | Plant Physiol. | pmid:12427975 |
| Wagner AH et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12426205 |
| Kuzuyama T | Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12353619 |
| Nishikimi T et al. | Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin. | 2002 | Eur. J. Pharmacol. | pmid:12398901 |
| Amin R et al. | Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235236 |
| Newton CJ et al. | Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. | 2002 | J. Endocrinol. | pmid:12098658 |
| Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
| Kasahara H et al. | Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. | 2002 | J. Biol. Chem. | pmid:12228237 |
| Sutherlin A et al. | Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. | 2002 | J. Bacteriol. | pmid:12107122 |
| Fahien LA and MacDonald MJ | The succinate mechanism of insulin release. | 2002 | Diabetes | pmid:12196457 |
| Christ M et al. | Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. | 2002 | Diabetes | pmid:12145183 |
| Okada K et al. | Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. | 2002 | Planta | pmid:12029484 |
| Konrad Z and Eichler J | Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. | 2002 | Biochem. J. | pmid:12069685 |
| Che P et al. | Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. | 2002 | Plant Physiol. | pmid:12068107 |
| Hamano Y et al. | Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036054 |
| Masferrer A et al. | Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. | 2002 | Plant J. | pmid:12000449 |
| Hümbelin M et al. | Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. | 2002 | Gene | pmid:12384294 |
| Virtanen SS et al. | Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | 2002 | Cancer Res. | pmid:11980672 |
| Naidu A et al. | Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. | 2002 | Brain Res. | pmid:12468034 |
| Paris D et al. | Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. | 2002 | Atherosclerosis | pmid:11888511 |
| Fu Z et al. | The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. | 2002 | J. Biol. Chem. | pmid:11877411 |
| Kalinowski L et al. | Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. | 2002 | Circulation | pmid:11864921 |
| Hurtado-Guerrrero R et al. | Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. | 2002 | FEBS Lett. | pmid:11801242 |
| Richard SB et al. | Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. | 2002 | J. Biol. Chem. | pmid:11786530 |
| Miyazaki A et al. | Effects of pravastatin sodium on mevalonate metabolism in common marmosets. | 2002 | J. Biochem. | pmid:12204108 |
| Marino M et al. | Age-related changes of cholesterol and dolichol biosynthesis in rat liver. | 2002 | Mech. Ageing Dev. | pmid:12044967 |
| Nagata N et al. | Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. | 2002 | Planta | pmid:12447549 |
| Blanco-Colio LM et al. | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. | 2002 | Atherosclerosis | pmid:11882313 |
| Miyazawa Y et al. | Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. | 2002 | Plant Cell Physiol. | pmid:12514251 |
| Gubina E et al. | CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. | 2002 | Blood | pmid:11895788 |
| Kumar B et al. | Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | 2002 | J. Neurosci. Res. | pmid:12111853 |
| Alla S et al. | [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. | 2002 | C. R. Biol. | pmid:12481687 |
| Holstein SA et al. | Isoprenoids influence expression of Ras and Ras-related proteins. | 2002 | Biochemistry | pmid:12427032 |
| Miyashita Y et al. | Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | 2002 | J. Atheroscler. Thromb. | pmid:12238640 |
| Carnesecchi S et al. | Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12388655 |
| Kalinowski L et al. | Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. | 2002 | J. Physiol. Pharmacol. | pmid:12512694 |
| Zager RA et al. | The mevalonate pathway during acute tubular injury: selected determinants and consequences. | 2002 | Am. J. Pathol. | pmid:12163393 |
| Pappu AS et al. | Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. | 2002 | J. Lipid Res. | pmid:12364550 |
| Parhami F et al. | Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. | 2002 | J. Bone Miner. Res. | pmid:12412807 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Eisenreich W et al. | Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. | 2002 | J. Org. Chem. | pmid:11856031 |
| Liu JC et al. | The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. | 2002 | Am. J. Chin. Med. | pmid:12568290 |
| Frenkel J et al. | Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | 2002 | Arthritis Rheum. | pmid:12384940 |
| Rohdich F et al. | Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818558 |
| Stamatakis K et al. | Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. | 2002 | J. Biol. Chem. | pmid:12384510 |
| Holstein SA et al. | Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. | 2002 | J. Biol. Chem. | pmid:11788600 |
| Kandoussi A et al. | HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells. | 2002 | Clin. Sci. | pmid:12193060 |
| Yokoyama K et al. | HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. | 2002 | Circulation | pmid:11864926 |
| Ledoux S et al. | Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases. | 2002 | Circ. Res. | pmid:11884371 |
| Han YS et al. | Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. | 2002 | Phytochemistry | pmid:11754943 |
| Grabińska K and Palamarczyk G | Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. | 2002 | FEMS Yeast Res. | pmid:12702274 |
| Li L et al. | Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. | 2002 | Mol. Pharmacol. | pmid:12181436 |
| Kuzuyama T et al. | Detection of the mevalonate pathway in Streptomyces species using the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. | 2002 | J. Antibiot. | pmid:12523826 |
| Arkwright PD et al. | Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. | 2002 | Clin. Exp. Immunol. | pmid:12452839 |
| Martin PD et al. | Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers. | 2002 | Br J Clin Pharmacol | pmid:12445025 |