MeSH term | MeSH ID | Detail |
---|---|---|
Sickle Cell Trait | D012805 | 4 associated lipids |
beta-Thalassemia | D017086 | 5 associated lipids |
Gastritis | D005756 | 27 associated lipids |
Anemia, Sickle Cell | D000755 | 34 associated lipids |
2,2-DIMETHYLBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Fermentation, Process, Intestinal Absorption, Energy Metabolism and Proteolysis. 2,2-dimethylbutyric acid often locates in host and Hepatic. The related lipids are Propionate, Butyrates, n-Butyrate, Valerates and blood lipid.
To understand associated biological information of 2,2-DIMETHYLBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2,2-DIMETHYLBUTYRIC ACID
MeSH term | MeSH ID | Detail |
---|---|---|
Sickle Cell Trait | D012805 | 4 associated lipids |
beta-Thalassemia | D017086 | 5 associated lipids |
Gastritis | D005756 | 27 associated lipids |
Anemia, Sickle Cell | D000755 | 34 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Knapp E et al. | Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents. | 2016 | Am. J. Hematol. | pmid:26661045 |
Dai Y et al. | Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms. | 2016 | Blood Cells Mol. Dis. | pmid:26603726 |
Mehraei M et al. | Target-based drug discovery for [Formula: see text]-globin disorders: drug target prediction using quantitative modeling with hybrid functional Petri nets. | 2016 | J Bioinform Comput Biol | pmid:27431020 |
Patthamalai P et al. | A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia. | 2014 | Blood | pmid:24652964 |
Reid ME et al. | A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. | 2014 | Am. J. Hematol. | pmid:24677033 |
Inati A et al. | A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in β-thalassaemia intermedia. | 2014 | Br. J. Haematol. | pmid:24224649 |
Kutlar A et al. | A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. | 2013 | Am. J. Hematol. | pmid:23828223 |
Fucharoen S et al. | A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia. | 2013 | Br. J. Haematol. | pmid:23530969 |
Kutlar A et al. | A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease. | 2012 | Am. J. Hematol. | pmid:22887019 |
Bhatia MS et al. | Synthesis, characterization and quantification of simvastatin metabolites and impurities. | 2011 Jul-Sep | Sci Pharm | pmid:21886906 |
Perrine SP et al. | Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers. | 2011 | J Clin Pharmacol | pmid:21422239 |
Terse PS et al. | Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats. | 2011 | Toxicol Pathol | pmid:21558467 |
Wang H et al. | In-situ XAFS studies of Mn12 molecular-cluster batteries: super-reduced Mn12 clusters in solid-state electrochemistry. | 2011 | Chem Asian J | pmid:21265025 |
Perrine SP et al. | Fetal globin gene inducers: novel agents and new potential. | 2010 | Ann. N. Y. Acad. Sci. | pmid:20712788 |
Galanello R and Origa R | Beta-thalassemia. | 2010 | Orphanet J Rare Dis | pmid:20492708 |
Barrios-González J and Miranda RU | Biotechnological production and applications of statins. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19820926 |
Parise RA et al. | Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18155649 |
Martin FP et al. | Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. | 2008 | Mol. Syst. Biol. | pmid:18197175 |
Martin FP et al. | Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. | 2008 | Mol. Syst. Biol. | pmid:18628745 |
Martin FP et al. | A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. | 2007 | Mol. Syst. Biol. | pmid:17515922 |