Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.
To understand associated biological information of Lysophosphatidylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lysophosphatidylcholine is suspected in Atherosclerosis, Ischemia, Septicemia, Obesity, Exanthema, hypercholesterolemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Lysophosphatidylcholine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.' (Parks BW et al., 2005) and Knock-out are used in the study 'Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2.' (Fisher AB et al., 2005).
Disease model are used in the study 'Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy.' (Thiele JR et al., 2014).
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Vuong TD et al. | Hypoalbuminemia increases lysophosphatidylcholine in low-density lipoprotein of normocholesterolemic subjects. | 1999 | Kidney Int. | pmid:10027937 |
Tokumura A et al. | Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma. | 1999 | Biochim. Biophys. Acta | pmid:10064906 |
Kita T | [Aging and atherosclerosis]. | 1998 | Nihon Ronen Igakkai Zasshi | pmid:10064965 |
Ma H et al. | Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes. | 1999 | Jpn. J. Pharmacol. | pmid:10082313 |
Fazeli A et al. | Sperm-oviduct interaction: induction of capacitation and preferential binding of uncapacitated spermatozoa to oviductal epithelial cells in porcine species. | 1999 | Biol. Reprod. | pmid:10084961 |
Anttinen H | Stimulation of collagen galactosyltransferase and glucosyltransferase activities by lysophosphatidylcholine. | 1976 | Biochem. J. | pmid:1008844 |
Rydström J et al. | The topology of the mitochondrial 11beta-hydroxylase system in bovine adrenal cortex. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1008873 |
Taniyama Y et al. | Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10092508 |
Shoda J et al. | Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis. | 1999 | Hepatology | pmid:10094942 |