| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Hyperlipoproteinemia Type IV | D006953 | 6 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
Lysophosphatidylcholine
Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.
Cross Reference
Introduction
To understand associated biological information of Lysophosphatidylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lysophosphatidylcholine?
Lysophosphatidylcholine is suspected in Atherosclerosis, Ischemia, Septicemia, Obesity, Exanthema, hypercholesterolemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lysophosphatidylcholine
PubChem Associated disorders and diseases
What pathways are associated with Lysophosphatidylcholine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lysophosphatidylcholine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lysophosphatidylcholine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lysophosphatidylcholine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lysophosphatidylcholine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Lysophosphatidylcholine?
Knock-out
Knock-out are used in the study 'Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.' (Parks BW et al., 2005) and Knock-out are used in the study 'Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2.' (Fisher AB et al., 2005).
Disease model
Disease model are used in the study 'Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy.' (Thiele JR et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Lysophosphatidylcholine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang J et al. | Plasma lipidomic signatures of spontaneous obese rhesus monkeys. | 2019 | Lipids Health Dis | pmid:30621707 |
| Semba RD et al. | Serum lipids in adults with late age-related macular degeneration: a case-control study. | 2019 | Lipids Health Dis | pmid:30621701 |
| Gayral M et al. | The Spatiotemporal Deposition of Lysophosphatidylcholine Within Starch Granules of Maize Endosperm and its Relationships to the Expression of Genes Involved in Endoplasmic Reticulum-Amyloplast Lipid Trafficking and Galactolipid Synthesis. | 2019 | Plant Cell Physiol. | pmid:30295886 |
| Lu YP et al. | Cord Blood Lysophosphatidylcholine 16: 1 is Positively Associated with Birth Weight. | 2018 | Cell. Physiol. Biochem. | pmid:29402770 |
| Drzazga A et al. | 2-OMe-lysophosphatidylcholine analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells: Evaluation of structure-dependent biological activity. | 2018 | Biochim. Biophys. Acta | pmid:29079451 |
| Baradaran S et al. | Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm. | 2018 | Life Sci. | pmid:30056861 |
| Cong L et al. | DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway. | 2018 | Int. J. Mol. Med. | pmid:29484368 |
| Chen J et al. | Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells. | 2018 | Mol Med Rep | pmid:29257345 |
| Goda T and Miyahara Y | Specific binding of human C-reactive protein towards supported monolayers of binary and engineered phospholipids. | 2018 | Colloids Surf B Biointerfaces | pmid:29172154 |
| Burton NO et al. | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. | 2018 | Nat Commun | pmid:30514845 |
| Kuang A et al. | Lipidomic Response to Coffee Consumption. | 2018 | Nutrients | pmid:30513727 |
| Fukushima K et al. | Promotion of cell-invasive activity through the induction of LPA receptor-1 in pancreatic cancer cells. | 2018 | J. Recept. Signal Transduct. Res. | pmid:30396320 |
| Yang F and Chen GX | Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis. | 2018 | World J. Gastroenterol. | pmid:30271079 |
| Tseng HC et al. | Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts. | 2018 | Cell. Mol. Life Sci. | pmid:30229288 |
| Cha MH et al. | Lysophosphatidylcholine induces expression of genes involved in cholesterol biosynthesis in THP-1 derived macrophages. | 2018 | Steroids | pmid:30217786 |
| Gonzalez-Granda A et al. | Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women. | 2018 | Nutrients | pmid:30200659 |
| Wang W et al. | Dysregulated serum metabolites in staging of hepatocellular carcinoma. | 2018 | Clin. Biochem. | pmid:30195484 |
| Dua A et al. | Characterization of a novel thiol activated phospholipase TAPLB1 from Trichosporon asahii MSR 54. | 2018 | Int. J. Biol. Macromol. | pmid:30153461 |
| Liu H et al. | Study on a dSPE-LC-MS/MS method for lysophosphatidylcholines and underivatized neurotransmitters in rat brain tissues. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:30125781 |
| Narayanan V et al. | Impairment of frequency-specific responses associated with altered electrical activity patterns in auditory thalamus following focal and general demyelination. | 2018 | Exp. Neurol. | pmid:30048715 |
| Natarajan A et al. | Liquid chromatography-tandem mass spectrometry method for estimation of a panel of lysophosphatidylcholines in dried blood spots for screening of X-linked adrenoleukodystrophy. | 2018 | Clin. Chim. Acta | pmid:30018013 |
| Wang C and Kotter MR | Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin. | 2018 | Methods Mol. Biol. | pmid:30006714 |
| Sun Z et al. | Novel SWATH technology for follicular fluid metabolomics in patients with endometriosis. | 2018 | Pharmazie | pmid:29880083 |
| Hellmuth C et al. | The impact of human breast milk components on the infant metabolism. | 2018 | PLoS ONE | pmid:29856767 |
| Lee H et al. | Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics. | 2018 | Chem. Phys. Lipids | pmid:29852124 |
| Lee SJ et al. | Comparative study on metabolite level in tissue-specific human mesenchymal stem cells by an ultra-performance liquid chromatography quadrupole time of flight mass spectrometry. | 2018 | Anal. Chim. Acta | pmid:29776537 |
| Matsuda A et al. | Lysophosphatidylcholine as a predictor of postoperative complications after colorectal cancer surgery. | 2018 | Surg. Today | pmid:29774420 |
| Schmedes M et al. | The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. | 2018 | Nutrients | pmid:29751643 |
| Zhang SY et al. | Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance. | 2018 | EBioMedicine | pmid:29735414 |
| Akbari A et al. | Adenosine A receptor blockade attenuates spatial memory deficit and extent of demyelination areas in lyolecithin-induced demyelination model. | 2018 | Life Sci. | pmid:29730168 |
| Henderson F et al. | Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry. | 2018 | Rapid Commun. Mass Spectrom. | pmid:29484723 |
| Dorninger F et al. | Alterations in the Plasma Levels of Specific Choline Phospholipids in Alzheimer's Disease Mimic Accelerated Aging. | 2018 | J. Alzheimers Dis. | pmid:29480199 |
| Habartová L et al. | Chiroptical spectroscopy and metabolomics for blood-based sensing of pancreatic cancer. | 2018 | Chirality | pmid:29473211 |
| Matsuoka H et al. | Neurotropin Accelerates the Differentiation of Schwann Cells and Remyelination in a Rat Lysophosphatidylcholine-Induced Demyelination Model. | 2018 | Int J Mol Sci | pmid:29419802 |
| Zhang M et al. | UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats. | 2018 | Int. J. Biol. Macromol. | pmid:29410058 |
| Shi Y et al. | Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination. | 2018 | Neurosci Bull | pmid:29397565 |
| Ren C et al. | Lipidomic analysis of serum samples from migraine patients. | 2018 | Lipids Health Dis | pmid:29394939 |
| Honjo M et al. | Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes. | 2018 | Invest. Ophthalmol. Vis. Sci. | pmid:29392315 |
| Li X et al. | IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14). | 2018 | Arterioscler. Thromb. Vasc. Biol. | pmid:29371247 |
| Sánchez-Villalba E et al. | Improved exogenous DNA uptake in bovine spermatozoa and gene expression in embryos using membrane destabilizing agents in ICSI-SMGT. | 2018 | Zygote | pmid:29334034 |
| Rindlisbacher B et al. | Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis - a potential biomarker role for LysoPC. | 2018 | Respir. Res. | pmid:29321022 |
| Papadopoulos GA et al. | Effects of lysolecithin supplementation in low-energy diets on growth performance, nutrient digestibility, viscosity and intestinal morphology of broilers. | 2018 | Br. Poult. Sci. | pmid:29293022 |
| Liang P et al. | Phospholipids composition and molecular species of large yellow croaker (Pseudosciaena crocea) roe. | 2018 | Food Chem | pmid:29287445 |
| Pleguezuelos-Villa M et al. | A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy. | 2018 | Colloids Surf B Biointerfaces | pmid:29216513 |
| Zhou SX et al. | High glucose/lysophosphatidylcholine levels stimulate extracellular matrix deposition in diabetic nephropathy via platelet‑activating factor receptor. | 2018 | Mol Med Rep | pmid:29207067 |
| Villamil-Ortiz JG et al. | Differential Pattern of Phospholipid Profile in the Temporal Cortex from E280A-Familiar and Sporadic Alzheimer's Disease Brains. | 2018 | J. Alzheimers Dis. | pmid:29125487 |
| Wang SM et al. | Identification of serum metabolites associated with obesity and traditional risk factors for metabolic disease in Chinese adults. | 2018 | Nutr Metab Cardiovasc Dis | pmid:29122443 |
| Lima MS et al. | Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission. | 2018 | Acta Trop. | pmid:29107570 |
| Plemel JR et al. | Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy. | 2018 | Glia | pmid:29068088 |
| Zhao Q et al. | Metabolic map of osthole and its effect on lipids. | 2018 | Xenobiotica | pmid:28287022 |