Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

Cross Reference

Introduction

To understand associated biological information of Lysophosphatidylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lysophosphatidylcholine?

Lysophosphatidylcholine is suspected in Atherosclerosis, Ischemia, Septicemia, Obesity, Exanthema, hypercholesterolemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lysophosphatidylcholine

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Insulinoma D007340 28 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Pulmonary Edema D011654 23 associated lipids
Peritonitis D010538 38 associated lipids
Proteinuria D011507 30 associated lipids
Arteriosclerosis D001161 86 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Lysophosphatidylcholine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lysophosphatidylcholine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Lysophosphatidylcholine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lysophosphatidylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Lysophosphatidylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lysophosphatidylcholine?

Knock-out

Knock-out are used in the study 'Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.' (Parks BW et al., 2005) and Knock-out are used in the study 'Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2.' (Fisher AB et al., 2005).

Disease model

Disease model are used in the study 'Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy.' (Thiele JR et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Lysophosphatidylcholine

Download all related citations
Per page 10 20 50 100 | Total 3448
Authors Title Published Journal PubMed Link
Putta P et al. Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties. 2016 Biochim. Biophys. Acta pmid:27480805
Xu J et al. Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. 2016 Dev. Cell pmid:27424497
Humer E et al. Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum. 2016 PLoS ONE pmid:27383746
Subbaiah PV et al. Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. 2016 Biochim. Biophys. Acta pmid:27178174
Parra Millán R et al. Efficacy of Lysophosphatidylcholine in Combination with Antimicrobial Agents against Acinetobacter baumannii in Experimental Murine Peritoneal Sepsis and Pneumonia Models. 2016 Antimicrob. Agents Chemother. pmid:27161639
Li X et al. Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation. 2016 Arterioscler. Thromb. Vasc. Biol. pmid:27127201
van de Beek MC et al. C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man. 2016 PLoS ONE pmid:27124591
Cash JG and Hui DY Liver-specific overexpression of LPCAT3 reduces postprandial hyperglycemia and improves lipoprotein metabolic profile in mice. 2016 Nutr Diabetes pmid:27110687
Hirsova P et al. Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. 2016 J. Lipid Res. pmid:27049024
Natarajan C et al. TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair. 2016 PLoS ONE pmid:27022724
Weigl S et al. The Vacuolar Proton-Cation Exchanger EcNHX1 Generates pH Signals for the Expression of Secondary Metabolism in Eschscholzia californica. 2016 Plant Physiol. pmid:26578709
Erkan E et al. Distinct urinary lipid profile in children with focal segmental glomerulosclerosis. 2016 Pediatr. Nephrol. pmid:26537928
Schall JI et al. Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial. 2016 J. Pediatr. Gastroenterol. Nutr. pmid:26465792
Haynes CA and De Jesús VR Simultaneous quantitation of hexacosanoyl lysophosphatidylcholine, amino acids, acylcarnitines, and succinylacetone during FIA-ESI-MS/MS analysis of dried blood spot extracts for newborn screening. 2016 Clin. Biochem. pmid:26432925
Merriman C et al. Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes. 2016 J. Biol. Chem. pmid:27875315
Klingler C et al. Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity. 2016 Biochim. Biophys. Acta pmid:27697477
Yin MZ et al. Identification of phosphatidylcholine and lysophosphatidylcholine as novel biomarkers for cervical cancers in a prospective cohort study. 2016 Tumour Biol. pmid:26566624
Uehara T et al. Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer. 2016 Ann. Surg. Oncol. pmid:25752890
Wang Y et al. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. 2016 Oncotarget pmid:27472391
Zhong L et al. Untargeted saliva metabonomics study of breast cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. 2016 Talanta pmid:27343615
Bansal P et al. Lysophosphatidylcholine plays critical role in allergic airway disease manifestation. 2016 Sci Rep pmid:27282246
Stefanescu H et al. Lyso-phosphatidylcholine: A potential metabolomic biomarker for alcoholic liver disease? 2016 Hepatology pmid:27123871
Medina CB and Ravichandran KS Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. 2016 Cell Death Differ. pmid:26891690
Mitchell NJ et al. Branched phospholipids render lipid vesicles more susceptible to membrane-active peptides. 2016 Biochim. Biophys. Acta pmid:26514602
Lo Van A et al. Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases. 2016 Biochimie pmid:27496085
Huang X et al. A New Strategy for Analyzing Time-Series Data Using Dynamic Networks: Identifying Prospective Biomarkers of Hepatocellular Carcinoma. 2016 Sci Rep pmid:27578360
Ke C et al. Plasma Metabolic Profiles in Women are Menopause Dependent. 2015 PLoS ONE pmid:26580805
Tobo A et al. Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses. 2015 PLoS ONE pmid:26070068
Benesch MG et al. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer. 2015 Endocr. Relat. Cancer pmid:26037280
Krzan M et al. Effect of products of PLA2 catalyzed hydrolysis of DLPC on motion of rising bubbles. 2015 Colloids Surf B Biointerfaces pmid:25724770
Chen X et al. Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease. 2015 Lipids Health Dis pmid:26714775
Gómez-Torres MJ et al. Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization. 2015 Reprod. Biol. Endocrinol. pmid:26553294
Smith CA et al. Altered Hippocampal Lipid Profile Following Acute Postnatal Exposure to Di(2-Ethylhexyl) Phthalate in Rats. 2015 Int J Environ Res Public Health pmid:26516880
Fogarty CE and Bergmann A The Sound of Silence: Signaling by Apoptotic Cells. 2015 Curr. Top. Dev. Biol. pmid:26431570
Siegel MO et al. HIV infection induces structural and functional changes in high density lipoproteins. 2015 Atherosclerosis pmid:26343868
Kucharova K and Stallcup WB NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair. 2015 J Neuroinflammation pmid:26338007
Goto T et al. Decreased expression of lysophosphatidylcholine (16:0/OH) in high resolution imaging mass spectrometry independently predicts biochemical recurrence after surgical treatment for prostate cancer. 2015 Prostate pmid:26332786
Nowak-Machen M et al. Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury. 2015 Purinergic Signal. pmid:26306905
Alakbarzade V et al. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. 2015 Nat. Genet. pmid:26005865
Farmer K et al. Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson's Disease. 2015 Int J Mol Sci pmid:26274953
You Y et al. Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination. 2015 J Vis Exp pmid:26273963
Park JY et al. Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. 2015 PLoS ONE pmid:26258408
Murph MM et al. Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma. 2015 Bioorg. Med. Chem. pmid:26190462
Raynor A et al. Saturated and mono-unsaturated lysophosphatidylcholine metabolism in tumour cells: a potential therapeutic target for preventing metastases. 2015 Lipids Health Dis pmid:26162894
Deatherage CL et al. Notch Transmembrane Domain: Secondary Structure and Topology. 2015 Biochemistry pmid:26023825
Lee HK et al. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. 2015 Glia pmid:25946682
Rittchen S et al. Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF). 2015 Biomaterials pmid:25934281
Furusho M et al. Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions. 2015 Glia pmid:25913734
Smani Y et al. Therapeutic efficacy of lysophosphatidylcholine in severe infections caused by Acinetobacter baumannii. 2015 Antimicrob. Agents Chemother. pmid:25896698
Najm FJ et al. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. 2015 Nature pmid:25896324
Keough MB et al. Experimental demyelination and remyelination of murine spinal cord by focal injection of lysolecithin. 2015 J Vis Exp pmid:25867716
Lee SY et al. Altered plasma lysophosphatidylcholines and amides in non-obese and non-diabetic subjects with borderline-to-moderate hypertriglyceridemia: a case-control study. 2015 PLoS ONE pmid:25856314
Wang BJ et al. [Association of ORMDL3 single nucleotide polymorphisms with lysophosphatidylcholine and apolipoprotein B levels in children with asthma]. 2015 Zhongguo Dang Dai Er Ke Za Zhi pmid:25815492
Rong X et al. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. 2015 Elife pmid:25806685
Muramatsu R et al. Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. 2015 J. Biol. Chem. pmid:25795781
Priolo C et al. Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25780943
Yang G et al. Lysophosphatidylcholine synthesis by lipase-catalyzed ethanolysis. 2015 J Oleo Sci pmid:25766935
Jové M et al. Metabolomics predicts stroke recurrence after transient ischemic attack. 2015 Neurology pmid:25471397
Curcic S et al. Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL. 2015 Biochim. Biophys. Acta pmid:25463476
Khan M et al. Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats. 2015 J Neuroinflammation pmid:25971887
Haynes CA and De Jesús VR The stability of hexacosanoyl lysophosphatidylcholine in dried-blood spot quality control materials for X-linked adrenoleukodystrophy newborn screening. 2015 Clin. Biochem. pmid:25307302
Lager I et al. Novel reactions in acyl editing of phosphatidylcholine by lysophosphatidylcholine transacylase (LPCT) and acyl-CoA:glycerophosphocholine acyltransferase (GPCAT) activities in microsomal preparations of plant tissues. 2015 Planta pmid:25298156
Stoffels JM et al. The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination. 2015 Glia pmid:25156142
Rosenbaum MA et al. Hypercholesterolemia inhibits re-endothelialization of arterial injuries by TRPC channel activation. 2015 J. Vasc. Surg. pmid:24820897
Akerele OA and Cheema SK Fatty acyl composition of lysophosphatidylcholine is important in atherosclerosis. 2015 Med. Hypotheses pmid:26604024
González-Thuillier I et al. Distribution of Lipids in the Grain of Wheat (cv. Hereward) Determined by Lipidomic Analysis of Milling and Pearling Fractions. 2015 J. Agric. Food Chem. pmid:26582143
Aumailley L et al. Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase. 2015 Exp. Gerontol. pmid:26521679
Pruzanski W et al. Diverse activity of human secretory phospholipases A2 on the migration of human vascular smooth muscle cells. 2015 Inflamm. Res. pmid:25999087
Lajoie DM and Cordes MH Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products. 2015 Toxicon pmid:26482933
Reichel M et al. Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. 2015 Biochim. Biophys. Acta pmid:26291032
Askari N et al. Tetracycline-regulated expression of OLIG2 gene in human dental pulp stem cells lead to mouse sciatic nerve regeneration upon transplantation. 2015 Neuroscience pmid:26254831
Kim JM et al. Stearoyl lysophosphatidylcholine prevents lipopolysaccharide-induced extracellular release of high mobility group box-1 through AMP-activated protein kinase activation. 2015 Int. Immunopharmacol. pmid:26218280
Foo A et al. Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and L-α-lysophosphatidylcholine. 2015 Eur. Biophys. J. pmid:26143502
Sutter I et al. Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. 2015 Atherosclerosis pmid:26093887
Drzazga A et al. Sulfur- and acyl chain-dependent influence of 2-methoxy-lysophosphatidylcholine analogues on β pancreatic cells. 2015 Curr Top Med Chem pmid:26088355
Ahn HY et al. The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects. 2015 Nutr Metab Cardiovasc Dis pmid:26044516
Rached F et al. Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A. 2015 Biochim. Biophys. Acta pmid:26037829
Li B et al. Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes. 2015 Food Funct pmid:26008201
Matsumoto Y and Sugimori D Substrate recognition mechanism of Streptomyces phospholipase D and enzymatic measurement of plasmalogen. 2015 J. Biosci. Bioeng. pmid:25900053
Morita M et al. Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells. 2015 J. Biochem. pmid:25998247
Klapper Y et al. Low affinity binding of plasma proteins to lipid-coated quantum dots as observed by in situ fluorescence correlation spectroscopy. 2015 Nanoscale pmid:25975280
Graessler J et al. Increasing plasma lysophosphatidylcholine levels in patients with regular dextran sulfate lipoprotein apheresis. 2015 Atheroscler Suppl pmid:25936322
Granafei S et al. Identification of isobaric lyso-phosphatidylcholines in lipid extracts of gilthead sea bream (Sparus aurata) fillets by hydrophilic interaction liquid chromatography coupled to high-resolution Fourier-transform mass spectrometry. 2015 Anal Bioanal Chem pmid:25935670
Shimizu R et al. Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis. 2015 J Hepatobiliary Pancreat Sci pmid:25921542
Sonomura K et al. Plasma lipid analysis by hydrophilic interaction liquid chromatography coupled with electrospray ionization tandem mass spectrometry. 2015 J Sep Sci pmid:25845351
Sakumoto H et al. Sinomenine and magnoflorine, major constituents of Sinomeni caulis et rhizoma, show potent protective effects against membrane damage induced by lysophosphatidylcholine in rat erythrocytes. 2015 J Nat Med pmid:25840917
Ahmadi-Abhari S et al. Rheological properties of wheat starch influenced by amylose-lysophosphatidylcholine complexation at different gelation phases. 2015 Carbohydr Polym pmid:25817659
Gayral M et al. Lipid partitioning in maize (Zea mays L.) endosperm highlights relationships among starch lipids, amylose, and vitreousness. 2015 J. Agric. Food Chem. pmid:25794198
Liu X et al. Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry. 2015 J. Proteome Res. pmid:25784130
Wang P et al. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. 2015 Life Sci. pmid:25736969
Barriga HM et al. Buffer-induced swelling and vesicle budding in binary lipid mixtures of dioleoylphosphatidylcholine:dioleoylphosphatidylethanolamine and dioleoylphosphatidylcholine:lysophosphatidylcholine using small-angle X-ray scattering and ³¹P static NMR. 2015 Langmuir pmid:25738977
Sheikh AM et al. Lysophosphatidylcholine increases the neurotoxicity of Alzheimer's amyloid β1-42 peptide: role of oligomer formation. 2015 Neuroscience pmid:25727637
Turgeon CT et al. Streamlined determination of lysophosphatidylcholines in dried blood spots for newborn screening of X-linked adrenoleukodystrophy. 2015 Mol. Genet. Metab. pmid:25481105
Jickling GC and Montaner J Lysophosphatidylcholine to stratify risk of ischemic stroke in TIA. 2015 Neurology pmid:25471396
Inose Y et al. Activated microglia in ischemic stroke penumbra upregulate MCP-1 and CCR2 expression in response to lysophosphatidylcholine derived from adjacent neurons and astrocytes. 2015 Neuropathology pmid:25443158
Cífková E et al. Determination of lipidomic differences between human breast cancer and surrounding normal tissues using HILIC-HPLC/ESI-MS and multivariate data analysis. 2015 Anal Bioanal Chem pmid:25352274
Ahmad E et al. Trehalose enhances osmotic tolerance and suppresses lysophosphatidylcholine-induced acrosome reaction in ram spermatozoon. 2015 Andrologia pmid:25269572
Gao X et al. Regulation profile of phosphatidylcholines (PCs) and lysophosphatidylcholines (LPCs) components towards UDP-glucuronosyltransferases (UGTs) isoforms. 2015 Xenobiotica pmid:25259654
Cho WH et al. Lysophosphatidylcholine as a prognostic marker in community-acquired pneumonia requiring hospitalization: a pilot study. 2015 Eur. J. Clin. Microbiol. Infect. Dis. pmid:25172637
Hong SH et al. Impact of lysophosphatidylcholine on survival and function of UEA-1(+)acLDL (+) endothelial progenitor cells in patients with coronary artery disease. 2015 Heart Vessels pmid:24510253