PE(15:0/20:0)

PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PE(15:0/20:0)?

PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Abortion, Habitual D000026 5 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Cataract D002386 34 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Choline Deficiency D002796 16 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Epilepsy D004827 35 associated lipids
Fatty Liver D005234 48 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Galactosemias D005693 5 associated lipids
Hamartoma Syndrome, Multiple D006223 1 associated lipids
Hemolysis D006461 131 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with PE(15:0/20:0)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PE(15:0/20:0)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PE(15:0/20:0)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PE(15:0/20:0)?

Knock-out

Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).

Cancer Model

Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PE(15:0/20:0)

Download all related citations
Per page 10 20 50 100 | Total 1374
Authors Title Published Journal PubMed Link
Largo E et al. Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer. 2016 Biochim. Biophys. Acta pmid:26464198
Ariöz C et al. Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes. 2014 Biochim. Biophys. Acta pmid:24726609
Miyamoto S and Tokuda H Diverse effects of phospholipids on lipoprotein sorting and ATP hydrolysis by the ABC transporter LolCDE complex. 2007 Biochim. Biophys. Acta pmid:17498646
Strömstedt AA et al. Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra. 2017 Biochim. Biophys. Acta pmid:28669767
Laurinavicius S et al. Transbilayer distribution of phospholipids in bacteriophage membranes. 2007 Biochim. Biophys. Acta pmid:17658459
Putta P et al. Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties. 2016 Biochim. Biophys. Acta pmid:27480805
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
Kannan M et al. Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae. 2016 Biochim. Biophys. Acta pmid:27678054
Unsay JD et al. Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. 2017 Biochim. Biophys. Acta pmid:27755971
Tatsuta T and Langer T Intramitochondrial phospholipid trafficking. 2017 Biochim. Biophys. Acta pmid:27542541
Dimmer KS and Rapaport D Mitochondrial contact sites as platforms for phospholipid exchange. 2017 Biochim. Biophys. Acta pmid:27477677
Palusińska-Szysz M et al. The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. 2016 Biochim. Biophys. Acta pmid:27094351
Hicks AM et al. Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. 2006 Biochim. Biophys. Acta pmid:16860597
Gabrys CM et al. Nuclear magnetic resonance evidence for retention of a lamellar membrane phase with curvature in the presence of large quantities of the HIV fusion peptide. 2010 Biochim. Biophys. Acta pmid:19616505
Álvarez R et al. G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization. 2015 Biochim. Biophys. Acta pmid:26253820
Stark B et al. Association of vasoactive intestinal peptide with polymer-grafted liposomes: structural aspects for pulmonary delivery. 2007 Biochim. Biophys. Acta pmid:17204237
Deng L et al. Incorporation and remodeling of phosphatidylethanolamine containing short acyl residues in yeast. 2010 Biochim. Biophys. Acta pmid:20176132
Martin ML et al. The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid. 2013 Biochim. Biophys. Acta pmid:23360770
Bogdanov M et al. Lipids and topological rules governing membrane protein assembly. 2014 Biochim. Biophys. Acta pmid:24341994
Pasenkiewicz-Gierula M et al. Computer modelling studies of the bilayer/water interface. 2016 Biochim. Biophys. Acta pmid:26825705