PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Largo E et al. | Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer. | 2016 | Biochim. Biophys. Acta | pmid:26464198 |
Ariöz C et al. | Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes. | 2014 | Biochim. Biophys. Acta | pmid:24726609 |
Miyamoto S and Tokuda H | Diverse effects of phospholipids on lipoprotein sorting and ATP hydrolysis by the ABC transporter LolCDE complex. | 2007 | Biochim. Biophys. Acta | pmid:17498646 |
Strömstedt AA et al. | Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra. | 2017 | Biochim. Biophys. Acta | pmid:28669767 |
Laurinavicius S et al. | Transbilayer distribution of phospholipids in bacteriophage membranes. | 2007 | Biochim. Biophys. Acta | pmid:17658459 |
Putta P et al. | Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties. | 2016 | Biochim. Biophys. Acta | pmid:27480805 |
Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
Kannan M et al. | Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae. | 2016 | Biochim. Biophys. Acta | pmid:27678054 |
Li Z et al. | The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis. | 2011 | Biochim. Biophys. Acta | pmid:21292027 |
Wriessnegger T et al. | Lipid analysis of mitochondrial membranes from the yeast Pichia pastoris. | 2009 | Biochim. Biophys. Acta | pmid:19168151 |
Dimmer KS and Rapaport D | Mitochondrial contact sites as platforms for phospholipid exchange. | 2017 | Biochim. Biophys. Acta | pmid:27477677 |
Hicks AM et al. | Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. | 2006 | Biochim. Biophys. Acta | pmid:16860597 |
Rosenberger S et al. | Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae. | 2009 | Biochim. Biophys. Acta | pmid:19830909 |
van Uitert I et al. | The influence of different membrane components on the electrical stability of bilayer lipid membranes. | 2010 | Biochim. Biophys. Acta | pmid:19835838 |
Marsh D | Structural and thermodynamic determinants of chain-melting transition temperatures for phospholipid and glycolipids membranes. | 2010 | Biochim. Biophys. Acta | pmid:19853577 |
Hall K et al. | Gly(6) of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes. | 2012 | Biochim. Biophys. Acta | pmid:22538355 |
Stark B et al. | Association of vasoactive intestinal peptide with polymer-grafted liposomes: structural aspects for pulmonary delivery. | 2007 | Biochim. Biophys. Acta | pmid:17204237 |
Martin ML et al. | The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid. | 2013 | Biochim. Biophys. Acta | pmid:23360770 |
Bogdanov M et al. | Lipids and topological rules governing membrane protein assembly. | 2014 | Biochim. Biophys. Acta | pmid:24341994 |
Pasenkiewicz-Gierula M et al. | Computer modelling studies of the bilayer/water interface. | 2016 | Biochim. Biophys. Acta | pmid:26825705 |