PE(15:0/20:0)

PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PE(15:0/20:0)?

PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Trypanosomiasis D014352 5 associated lipids
Melanoma D008545 69 associated lipids
Weight Gain D015430 101 associated lipids
Thrombosis D013927 49 associated lipids
Alzheimer Disease D000544 76 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Psoriasis D011565 47 associated lipids
Epilepsy D004827 35 associated lipids
Galactosemias D005693 5 associated lipids
Toxoplasmosis D014123 9 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Trematode Infections D014201 8 associated lipids
Tangier Disease D013631 8 associated lipids
Abortion, Habitual D000026 5 associated lipids
Choline Deficiency D002796 16 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Bacteremia D016470 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Thinness D013851 11 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Venous Thrombosis D020246 11 associated lipids
Hamartoma Syndrome, Multiple D006223 1 associated lipids
Sneddon Syndrome D018860 1 associated lipids
Activated Protein C Resistance D020016 1 associated lipids
Venous Thromboembolism D054556 2 associated lipids
Chondrodysplasia Punctata, Rhizomelic D018902 4 associated lipids
Iron Overload D019190 11 associated lipids
Barth Syndrome D056889 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PE(15:0/20:0)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PE(15:0/20:0)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PE(15:0/20:0)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PE(15:0/20:0)?

Knock-out

Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).

Cancer Model

Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PE(15:0/20:0)

Download all related citations
Per page 10 20 50 100 | Total 1374
Authors Title Published Journal PubMed Link
Kol MA et al. Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli. 2004 Biochim. Biophys. Acta pmid:15164768
Brown AJ Of cholesterol-free mice and men. 2004 Curr. Opin. Lipidol. pmid:15166797
Mead FC and Williams AJ Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2). 2004 Biophys. J. pmid:15361409
Zhang N et al. [The enhancing effect of tomato lectin modified liposomes of insulin on oral absorption in mice]. 2004 Yao Xue Xue Bao pmid:15338884
Meuillet EJ et al. Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity. 2004 Arch. Biochem. Biophys. pmid:15313215
Liu F et al. Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylethanolamine Bilayers. 2004 Biophys. J. pmid:15454444
Wang Y et al. Regulation of signal peptidase by phospholipids in membrane: characterization of phospholipid bilayer incorporated Escherichia coli signal peptidase. 2004 Biochemistry pmid:14705954
Bleijerveld OB et al. Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol. 2004 Biochem. J. pmid:14759225
Otto GP et al. Dictyostelium macroautophagy mutants vary in the severity of their developmental defects. 2004 J. Biol. Chem. pmid:14736886
Choi HS et al. Regulation of phospholipid synthesis in the yeast cki1Delta eki1Delta mutant defective in the Kennedy pathway. The Cho1-encoded phosphatidylserine synthase is regulated by mRNA stability. 2004 J. Biol. Chem. pmid:14739287
Polozov IV and Gawrisch K Domains in binary SOPC/POPE lipid mixtures studied by pulsed field gradient 1H MAS NMR. 2004 Biophys. J. pmid:15345553
Berson EL et al. Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. 2004 Arch. Ophthalmol. pmid:15364709
Kodas E et al. Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. 2004 J. Neurochem. pmid:15086526
Shaikh SR et al. Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study. 2004 Biophys. J. pmid:15345554
Darville T et al. Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans. 2004 Microbes Infect. pmid:15050964
Schleheck D et al. Parvibaculum lavamentivorans gen. nov., sp. nov., a novel heterotroph that initiates catabolism of linear alkylbenzenesulfonate. 2004 Int. J. Syst. Evol. Microbiol. pmid:15388700
Johnston NC et al. Phospholipids of Clostridium perfringens: a reexamination. 2004 FEMS Microbiol. Lett. pmid:15043870
Trajkovic-Bodennec S et al. Phosphatidylcholine metabolism is altered in a monocyte-derived macrophage model of Gaucher disease but not in lymphocytes. 2004 Jul-Aug Blood Cells Mol. Dis. pmid:15223015
Vasil'eva OB et al. [Biochemical properties of the the lipoproteins lipid composition in fishes of the different ecology: trout Salmo irideus L. and whitefish Coregonus lavaretus L]. 2004 Mar-Apr Izv. Akad. Nauk. Ser. Biol. pmid:15131975
Malisiova F et al. Liposomal formulations from phospholipids of Greek almond oil. Properties and biological activity. 2004 May-Jun Z. Naturforsch., C, J. Biosci. pmid:18998396